Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Yu-Shun Tian"'
Publikováno v:
Molecules, Vol 28, Iss 4, p 1717 (2023)
Combretastatin A-4 (CA-4) is a potent tubulin polymerisation inhibitor. However, the clinical application of CA-4 is limited owing to its low aqueous solubility and the easy conversion of the olefin double bond from the more active cis- to the less a
Externí odkaz:
https://doaj.org/article/7afa424d702c41cebe23328b580de100
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 1554-1564 (2018)
To identify anticancer agents with high potency and low toxicity, a series of (Z)-styrylbenzene derivatives were synthesised and evaluated for anticancer activities using a panel of nine cancer cell lines and two noncancerous cell lines. Most derivat
Externí odkaz:
https://doaj.org/article/e620989c8d2e4fa4b1711de2aead7375
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 32, Iss 1, Pp 1111-1119 (2017)
A new series of novel 7-hydroxy-4-phenylchromen-2-one (1a)–linked 1,2,4-triazoles were synthesised using a click chemistry approach. All derivatives were subjected to 3-(4,5-dimethylthiazol-yl)-diphenyl tetrazolium bromide (MTT) cytotoxicity screen
Externí odkaz:
https://doaj.org/article/6ff61742c1a7483cb3a08ca117f4bf02
Publikováno v:
Molecules, Vol 24, Iss 1, p 121 (2018)
Six series of novel isosteviol derivatives; modified in the C-19 position; were synthesized; and their antiproliferative activity was evaluated against three human cancer cell lines (HCT-116; BEL-7402; HepG2) and the human L02 normal cell line in vit
Externí odkaz:
https://doaj.org/article/031d1d02301f447a83d6fa5f478cd8f8
Publikováno v:
Molecules, Vol 23, Iss 9, p 2243 (2018)
The aim of the present study was to determine the cytotoxic effects of a series of novel dehydroepiandrosterone derivatives containing triazole at the C16 position on human cancer cells. The cancer cells used in the present study were A549, Hela, Hep
Externí odkaz:
https://doaj.org/article/3c45eca829ce4e2c9f1cee13313e582b
Publikováno v:
European Journal of Medicinal Chemistry. 173:15-31
A series of novel oridonin derivatives bearing various substituents on the 14-OH position were designed and synthesised. Their antitumour activity was evaluated in vitro against three human cancer cell lines (HCT116, BEL7402, and MCF7). Most tested d
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 1554-1564 (2018)
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 1554-1564 (2018)
To identify anticancer agents with high potency and low toxicity, a series of (Z)-styrylbenzene derivatives were synthesised and evaluated for anticancer activities using a panel of nine cancer cell lines and two noncancerous cell lines. Most derivat
Synthesis and biological evaluation of dihydrotriazine derivatives as potential antibacterial agents
Publikováno v:
Chinese Chemical Letters. 28:1737-1742
A series of 1,4-dihydro-1,3,5-triazine derivatives were designed and synthesized and their antibacterial and antifungal activities were evaluated. Most of the synthesized compounds showed potent inhibition of several Gram-positive bacterial strains (
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:81-85
Thirty novel derivatives of 2,3-diaryl acrylonitrile were synthesized and evaluated for biological activity. Preliminary investigations of antitumor activity in vitro showed that most of the synthesized compounds have significant antiproliferative ef
Publikováno v:
Molecules
Molecules, Vol 24, Iss 1, p 121 (2018)
Volume 24
Issue 1
Molecules, Vol 24, Iss 1, p 121 (2018)
Volume 24
Issue 1
Six series of novel isosteviol derivatives
modified in the C-19 position
were synthesized
and their antiproliferative activity was evaluated against three human cancer cell lines (HCT-116
BEL-7402
HepG2) and the human L02 nor
modified in the C-19 position
were synthesized
and their antiproliferative activity was evaluated against three human cancer cell lines (HCT-116
BEL-7402
HepG2) and the human L02 nor