Výsledky vyhledávání

Dysregulated Smooth Muscle Cell BMPR2–ARRB2 Axis Causes Pulmonary Hypertension

Autor: Lingli Wang, Jan-Renier Moonen, Aiqin Cao, Sarasa Isobe, Caiyun G. Li, Nancy F. Tojais, Shalina Taylor, David P. Marciano, Pin-I. Chen, Mingxia Gu, Dan Li, Rebecca L. Harper, Nesrine El-Bizri, Yu-Mee Kim, Kryn Stankunas, Marlene Rabinovitch

Publikováno v: Circulation Research. 132:545-564

Objective: Mutations in BMPR2 (bone morphogenetic protein receptor 2) are associated with familial and sporadic pulmonary arterial hypertension (PAH). The functional and molecular link between loss of BMPR2 in pulmonary artery smooth muscle cells (PA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d1b4e5aab3c4e747e36400325397c920
https://doi.org/10.1161/circresaha.121.320541

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Reduced BMPR2 expression induces GM-CSF translation and macrophage recruitment in humans and mice to exacerbate pulmonary hypertension

Publikováno v: The Journal of Experimental Medicine

Reduced expression of bone morphogenetic protein receptor 2 subverts a stress granule response, heightens GM-CSF mRNA translation, and increases inflammatory cell recruitment to exacerbate pulmonary arterial hypertension.
Idiopathic pulmonary ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::156b333d34e856d8f84fdca71eed27ee
https://doi.org/10.1084/jem.20111741

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Hypoxia-Inducible Factor-1α in Pulmonary Artery Smooth Muscle Cells Lowers Vascular Tone by Decreasing Myosin Light Chain Phosphorylation

Autor: Yu-Mee Kim, David N. Cornfield, Cristina M. Alvira, Lihua Ying, Sushma Reddy, Elizabeth A. Barnes

Publikováno v: Circulation Research. 112:1230-1233

Rationale: Hypoxia-inducible factor-1α (HIF-1α), an oxygen (O 2 )-sensitive transcription factor, mediates transcriptional responses to low-O 2 tension states. Although acute hypoxia causes pulmonary vasoconstriction and chronic hypoxia can cause v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33c9d620dae7e84fb35b2da2fd00005c
https://doi.org/10.1161/circresaha.112.300646

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Neutrophil Elastase Is Produced by Pulmonary Artery Smooth Muscle Cells and Is Linked to Neointimal Lesions

Autor: Gabriela Rodriguez-Colon, Cristina M. Alvira, Hirofumi Sawada, Yu-Mee Kim, Andrew Orton, Lingli Wang, Edda Spiekerkoetter, Leila Haghighat, Mingming Zhao, Marlene Rabinovitch, Swati Acharya

Publikováno v: The American Journal of Pathology. 179:1560-1572

Previously, we reported that murine gammaherpesvirus-68 (M1-MHV-68) induces pulmonary artery (PA) neointimal lesions in S100A4-overexpressing, but not in wild-type (C57), mice. Lesions were associated with heightened lung elastase activity and PA ela

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30dfa339359720d0d882f88040dbf2b2
https://doi.org/10.1016/j.ajpath.2011.05.051

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Inhibition of Transforming Growth Factor β Worsens Elastin Degradation in a Murine Model of Kawasaki Disease

Autor: Rae S. M. Yeung, Chihhsin Chen, Cristina M. Alvira, Christophe Guignabert, Lingli Wang, Marlene Rabinovitch, Trang T. Duong, Yu Mee Kim, Dean Y. Li

Publikováno v: The American Journal of Pathology. 178:1210-1220

Kawasaki disease (KD) is an acute inflammatory illness marked by coronary arteritis. However, the factors increasing susceptibility to coronary artery lesions are unknown. Because transforming growth factor (TGF) β increases elastin synthesis and su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a86c1706025d2b5d08eb865e3dab0982
https://doi.org/10.1016/j.ajpath.2010.11.054

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Reactivation of γHV68 induces neointimal lesions in pulmonary arteries of S100A4/Mts1-overexpressing mice in association with degradation of elastin

Autor: Katie Lynn Pricola, Noona Ambartsumian, Marlene Rabinovitch, Cristina M. Alvira, Yu-Mee Kim, Edda Spiekerkoetter, Alexandra Bruneau, Lingli Wang

Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology. 294:L276-L289

S100A4/Mts-overexpressing mice have thick elastic laminae and mild pulmonary arterial hypertension (PAH), and the occasional older mouse develops occlusive neointimal lesions and perivascular inflammation. We hypothesized that a vasculotropic virus c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b0542f667bd6d18f2b649287742dbad
https://doi.org/10.1152/ajplung.00414.2007

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Zn2+-induced IL-8 expression involves AP-1, JNK, and ERK activities in human airway epithelial cells

Autor: Weidong Wu, Philip A. Bromberg, James M. Samet, William Reed, Yu Mee Kim, Lee M. Graves

Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology. 290:L1028-L1035

Exposure to zinc-laden particulate matter in ambient and occupational settings has been associated with proinflammatory responses in the lung. IL-8 is an important proinflammatory cytokine in the human lung and is induced in human airway epithelial c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1afca98d661c7691de7ab11bac64421
https://doi.org/10.1152/ajplung.00479.2005

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Hypoxia-inducible factor-1α regulates KCNMB1 expression in human pulmonary artery smooth muscle cells

Autor: David N. Cornfield, Yu-Mee Kim, Shu-Chen Lyu, Eloa S. Adams, Cristina M. Alvira, Yong-Tae Ahn

Previously, we observed that hypoxia increases the expression of the β1-subunit ( KCNMB1) of the calcium-sensitive potassium channel (BKCa). Herein, we elucidate the mechanism whereby hypoxia increases KCNMB1 expression in human pulmonary artery smo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cd966b42f8aca95316c18f9ed6a17e9
https://europepmc.org/articles/PMC3289270/

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