Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Yu-Ling Leu"'
Autor:
Tian-Lu Cheng, Hsin-Ell Wang, Kai-Chuan Chen, Chien-Han Kao, Chih-Hung Chuang, Jaw-Yuan Wang, Steve R. Roffler, Yu-Ling Leu, Ta-Chun Cheng, Yu-Cheng Su
Supplementary Figure S1. In vivo imaging of endogenous β-glucuronidase by TrapG probes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19d621a7ec2c83050bbd4749a20ab360
https://doi.org/10.1158/1535-7163.22502004.v1
https://doi.org/10.1158/1535-7163.22502004.v1
Autor:
Tian-Lu Cheng, Hsin-Ell Wang, Kai-Chuan Chen, Chien-Han Kao, Chih-Hung Chuang, Jaw-Yuan Wang, Steve R. Roffler, Yu-Ling Leu, Ta-Chun Cheng, Yu-Cheng Su
Supplementary methods. Chemical Synthesis of TrapG probes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce952e3d2830becabca3bae2e0cf2df9
https://doi.org/10.1158/1535-7163.22502001.v1
https://doi.org/10.1158/1535-7163.22502001.v1
Autor:
Wen-Wei Lin, Yi-Jung Huang, Yen-Tseng Wang, Yun-Syuan Lin, Nonsikelelo Mazibuko, Chien-Shu Chen, Tian-Lu Cheng, Chih-Shiang Chang, Yu-Ling Leu, Chiao-Yun Chen, Chih-Hung Chuang
Publikováno v:
Virus Research. 329:199092
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a42bed7e3deec641d9df27d3cda93465
https://doi.org/10.1016/j.virusres.2023.199092
https://doi.org/10.1016/j.virusres.2023.199092
Autor:
Tian-Lu Cheng, Chih Hung Chuang, Yu Ling Leu, Ta Chun Cheng, Jaw-Yuan Wang, Kai Chuan Chen, Hsin Ell Wang, Steve R. Roffler, Chien Han Kao, Yu-Cheng Su
Publikováno v:
Molecular Cancer Therapeutics. 13:2852-2863
Beta-glucuronidase (βG) is a potential biomarker for cancer diagnosis and prodrug therapy. The ability to image βG activity in patients would assist in personalized glucuronide prodrug cancer therapy. However, whole-body imaging of βG activity for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e0a179019d7bb31650ba45320e21d92
https://doi.org/10.1158/1535-7163.mct-14-0212
https://doi.org/10.1158/1535-7163.mct-14-0212
Autor:
Yu-Cheng Su, Yu-Ling Leu, Chih-Hung Chuang, I-Hong Harn, Chien-Han Kao, Chien Shu Chen, Kuan-Yi Liu, Kuo-Hsiang Chuang, Ta-Chun Cheng, Shey Cherng Tzou, Tian-Lu Cheng, Steve R. Roffler
Publikováno v:
Journal of the American Chemical Society. 134:3103-3110
β-glucuronidase is an attractive reporter and prodrug-converting enzyme. The development of near-IR (NIR) probes for imaging of β-glucuronidase activity would be ideal to allow estimation of reporter expression and for personalized glucuronide prod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5244d184907c36a4e6c0febf8d3c8d7
https://doi.org/10.1021/ja209335z
https://doi.org/10.1021/ja209335z
Publikováno v:
Journal of Medicinal Chemistry. 51:1740-1746
A beta-glucuronidase-activated prodrug approach was applied to 10-hydroxycamptothecin, a Camptotheca alkaloid with promising antitumor activity but poor water solubility. We synthesized a glucuronide prodrug of 10-hydroxycamptothecin ( 7) in which gl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1d4d5a5872453c154ee115a8c1acbbb
https://doi.org/10.1021/jm701151c
https://doi.org/10.1021/jm701151c
Autor:
Zeljko M. Prijovich, Yu-Ling Leu, Chih Hung Chuang, Kai-Chuan Chen, Bing-Mae Chen, Ta-Chun Cheng, Steve R. Roffler
Publikováno v:
Cancer Gene Therapy. 14:187-200
Gene-mediated enzyme prodrug therapy (GDEPT) seeks to increase the therapeutic index of anti-neoplastic agents by promoting selective activation of relatively nontoxic drug derivatives at sites of specific enzyme expression. Glucuronide prodrugs are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22c87510f345060aa0ca516c5d032db5
https://doi.org/10.1038/sj.cgt.7700999
https://doi.org/10.1038/sj.cgt.7700999
Autor:
Chin-Fen Lee, Yen-Chywan Liaw, Shun-Li Wang, Yu-Ling Leu, Pei-Chie Tsou, Ji-Wang Chern, Ruwen Jou, Shaw-Man Hsu, Hua-Mei Lin
Publikováno v:
Journal of Medicinal Chemistry. 40:2276-2286
A series of sulfonyl-N-hydroxyguanidine derivatives was designed and synthesized for cytotoxic evaluation as potential anticancer agents on the basis of the lead compound LY-181984. Replacement of the ureido moiety of the lead compound with hydroxygu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fe86de28484bc5cc546b4a0a33b9081
https://doi.org/10.1021/jm9607818
https://doi.org/10.1021/jm9607818
Autor:
Zeljko M. Prijovich, Wu Sy, Tian-Lu Cheng, Bing-Mae Chen, Kai-Chuan Chen, Hsin Ell Wang, Yu-Ling Leu, Roffler
Publikováno v:
Bioconjugate chemistry. 22(5)
Antibody-directed enzyme prodrug therapy (ADEPT) utilizing β-glucuronidase is a promising method to enhance the therapeutic index of cancer chemotherapy. In this approach, an immunoenzyme (antibody-β-glucuronidase fusion protein) is employed to sel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0356c83248c986242de1cb2680bb8703
https://pubmed.ncbi.nlm.nih.gov/21443266
https://pubmed.ncbi.nlm.nih.gov/21443266
Autor:
Shun-Li Wang, Yu-Ling Leu, Ruwen Jou, Shaw-Man Hsu, Hua-Mei Lin, Pei-Chie Tsou, Ji-Wang Chern, Yen-Chywan Liaw, Chin-Fen Lee
Publikováno v:
ChemInform. 28
A series of sulfonyl-N-hydroxyguanidine derivatives was designed and synthesized for cytotoxic evaluation as potential anticancer agents on the basis of the lead compound LY-181984. Replacement of the ureido moiety of the lead compound with hydroxygu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::678858eb03bf6ff2d1a8d356a84ffc6d
https://doi.org/10.1002/chin.199742123
https://doi.org/10.1002/chin.199742123