Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Yu-Kun Jennifer Zhang"'
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e59122 (2013)
Acute fasting causes elevated oxidative stress. The current study investigated the effects of the nuclear factor erythoid 2-related factor 2 (Nrf2), the sensor of oxidative stress in cells, on energy homeostasis and liver pathophysiology during fasti
Externí odkaz:
https://doaj.org/article/df064c697b5b441684d66199e37e3160
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e16683 (2011)
Diurnal fluctuation of bile acid (BA) concentrations in the enterohepatic system of mammals has been known for a long time. Recently, BAs have been recognized as signaling molecules beyond their well-established roles in dietary lipid absorption and
Externí odkaz:
https://doaj.org/article/c6a5efadbfda4d66856b2a172acfae40
Publikováno v:
Chronobiology International. 30:1135-1143
Sex differences and circadian variation are two major factors that affect the expression of drug-processing genes. This study aimed to examine sex differences in the circadian variation of hepatic cytochrome P450 (Cyp) genes and corresponding nuclear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a298570a38feb12d074a5289c2e99b5a
https://doi.org/10.3109/07420528.2013.805762
https://doi.org/10.3109/07420528.2013.805762
Publikováno v:
Toxicology and Applied Pharmacology. 245:326-334
Oxidative stress has been proposed as an important promoter of the progression of fatty liver diseases. The current study investigates the potential functions of the Nrf2-Keap1 signaling pathway, an important hepatic oxidative stress sensor, in a rod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39839761ce431ffb86090df5280677a8
https://doi.org/10.1016/j.taap.2010.03.016
https://doi.org/10.1016/j.taap.2010.03.016
Publikováno v:
Journal of Biochemistry. 145:609-623
The mammalian clock regulates major aspects of energy metabolism, including glucose and lipid homoeostasis as well as mitochondrial oxidative metabolism. This study is to identify specific patterns of circadian rhythms for lipid homoeostasis in both
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04e89cc1433155394372e1f59b6b4680
https://doi.org/10.1093/jb/mvp018
https://doi.org/10.1093/jb/mvp018
The nuclear receptor constitutive androstane receptor (CAR) is a key regulator for drug metabolism in liver. Human CAR (hCAR) transcripts are subjected to alternative splicing. Some hCAR splicing variants (SVs) have been shown to encode functional pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d37dfd57c3d911bfa3e558f241396c5
https://europepmc.org/articles/PMC3576005/
https://europepmc.org/articles/PMC3576005/
Publikováno v:
Toxicology and applied pharmacology. 264(3)
Nrf2, a master regulator of intracellular redox homeostasis, is indicated to participate in fatty acid metabolism in liver. However, its role in diet-induced obesity remains controversial. In the current study, genetically engineered Nrf2-null, wild-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9556eefc85d1299dcfcccfeb766cec1e
https://pubmed.ncbi.nlm.nih.gov/23017736
https://pubmed.ncbi.nlm.nih.gov/23017736
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e16683 (2011)
PLoS ONE
PLoS ONE
Background Diurnal fluctuation of bile acid (BA) concentrations in the enterohepatic system of mammals has been known for a long time. Recently, BAs have been recognized as signaling molecules beyond their well-established roles in dietary lipid abso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23071a778e1206e70a15d3164c7da480
http://europepmc.org/articles/PMC3035620?pdf=render
http://europepmc.org/articles/PMC3035620?pdf=render
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 38(7)
Liver is the major organ that eliminates xenobiotics from the body, a process that is accomplished by a series of drug-processing genes (DPGs). These genes encode transporters on both basolateral and apical membranes of hepatocytes, as well as phase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cea46df7c1385dceff20d13246dedb0
https://pubmed.ncbi.nlm.nih.gov/20382754
https://pubmed.ncbi.nlm.nih.gov/20382754
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 37(1)
Temporal coordination of hepatic drug-processing gene (DPG) expression facilitates absorption, biotransformation, and excretion of exogenous and endogenous compounds. To further elucidate the circadian rhythm of hepatic DPG expression, male C57BL/6 m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::943a1df667e0b4ce18ededab58fdb0ee
https://pubmed.ncbi.nlm.nih.gov/18838502
https://pubmed.ncbi.nlm.nih.gov/18838502