Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Yu-Ki Tahara"'
Autor:
Ling Zhang, Laura Misiara, Govindi J. Samaranayake, Nisha Sharma, Dao M. Nguyen, Yu-Ki Tahara, Eric T. Kool, Priyamvada Rai
Publikováno v:
Redox Biology, Vol 40, Iss , Pp 101848- (2021)
Cancer cells develop protective adaptations against oxidative DNA damage, providing a strong rationale for targeting DNA repair proteins. There has been a high degree of recent interest in inhibiting the mammalian Nudix pyrophosphatase MutT Homolog 1
Externí odkaz:
https://doaj.org/article/731941f3c3714aa9adb34e60d80e9306
Autor:
R. Stephen Lloyd, Erdem Coskun, Pawel Jaruga, Eric T. Kool, Melis Kant, Yu Ki Tahara, Miral Dizdaroglu
Publikováno v:
ACS Chem Biol
DNA glycosylases involved in the first step of the DNA base excision repair pathway are promising targets in cancer therapy. There is evidence that reduction of their activities may enhance cell killing in malignant tumors. Recently, two tetrahydroqu
Autor:
Qun Wu, Jianxin Jiang, Pan Gao, Eric T. Kool, Ashley R. Gao, David L. Wilson, Zhihan Wang, Jinliang Yang, Min Wu, Ping Lin, Biao Wang, Yu-Ki Tahara, Chuanmin Zhou, Qinqin Pu, Madison Overby, Zhenwei Xia, Shugang Qin
Publikováno v:
The Journal of Immunology. 205:2231-2242
The DNA repair enzyme 8-oxoguanine DNA glycosylase 1 (OGG1), which excises 8-oxo-7,8-dihydroguanine lesions induced in DNA by reactive oxygen species, has been linked to the pathogenesis of lung diseases associated with bacterial infections. A recent
Autor:
Shugang, Qin, Ping, Lin, Qun, Wu, Qinqin, Pu, Chuanmin, Zhou, Biao, Wang, Pan, Gao, Zhihan, Wang, Ashley, Gao, Madison, Overby, Jinliang, Yang, Jianxin, Jiang, David L, Wilson, Yu-Ki, Tahara, Eric T, Kool, Zhenwei, Xia, Min, Wu
Publikováno v:
J Immunol
The DNA repair enzyme 8-oxoguanine DNA glycosylase 1 (OGG1), which excises 8-oxo-7,8-dihydroguanine (8-oxoG) lesions induced in DNA by reactive oxygen species, has been linked to the pathogenesis of lung diseases associated with bacterial infections.
Publikováno v:
ACS chemical biology. 14(12)
Oxidative damage in DNA is one of the primary sources of mutations in the cell. The activities of repair enzymes 8-oxoguanine DNA glycosylase (OGG1) and human MutT Homologue 1 (NUDT1 or MTH1), which work together to ameliorate this damage, are closel
Autor:
Ling Zhang, Nisha Sharma, Eric T. Kool, Yu-Ki Tahara, Priyamvada Rai, Dao M. Nguyen, Laura Misiara Lincheta, Govindi Jayanika Samaranayake
Publikováno v:
Cancer Research. 81:2076-2076
Increased metabolic activity of cancer cells due to uncontrolled proliferation, often leads to the accumulation of reactive oxygen species (ROS). High ROS can produce tumor-suppressive oxidative DNA damage either directly in the genome or through oxi
Autor:
Eric T. Kool, Nisha Sharma, Govindi J. Samaranayake, Dao M. Nguyen, Priyamvada Rai, Laura Misiara, Yu Ki Tahara, Ling Zhang
Publikováno v:
Redox Biology
Redox Biology, Vol 40, Iss, Pp 101848-(2021)
Redox Biology, Vol 40, Iss, Pp 101848-(2021)
Cancer cells develop protective adaptations against oxidative DNA damage, providing a strong rationale for targeting DNA repair proteins. There has been a high degree of recent interest in inhibiting the mammalian Nudix pyrophosphatase MutT Homolog 1
Autor:
Zachary Nguyen, Eric T. Kool, Marta Jimenez, Yu-Ki Tahara, Daniel King, David L. Wilson, Debin Ji, Andrew A. Beharry, Anna M. Kietrys, Douglas S. Auld
Publikováno v:
Journal of the American Chemical Society. 140(6)
The activity of DNA repair enzyme 8-oxoguanine DNA glycosylase (OGG1), which excises oxidized base 8-oxoguanine (8-OG) from DNA, is closely linked to mutagenesis, genotoxicity, cancer, and inflammation. To test the roles of OGG1-mediated repair in th
Autor:
Kyalo Stephen Kanyiva, Yu-ki Tahara, Tohru Taniguchi, Kenji Monde, Takanori Shibata, Shuhei Obinata, Attila Mándi
Publikováno v:
ChemInform. 47
Publikováno v:
Chemical communications (Cambridge, England). 51(93)
Ir-catalyzed sp(3) C-H alkylation of γ-butyrolactam with alkenes was used for the highly enantioselective synthesis of 5-substituted γ-lactams, which were readily converted into chiral 4-substituted γ-amino acids. A broad scope of alkenes was amen