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Akademický článek

Toll‐interacting protein inhibits transforming growth factor beta signaling in mouse lung fibroblasts

Autor: Yu‐Hua Chow, Cecilia López‐Martínez, W. Conrad Liles, William A. Altemeier, Sina A. Gharib, Chi F. Hung

Publikováno v: FASEB BioAdvances, Vol 6, Iss 1, Pp 12-25 (2024)

Abstract Variations in the Toll‐interacting protein (TOLLIP) gene have been identified in genome‐wide association studies to correlate with risk of disease, mortality, and response to N‐acetylcysteine therapy in idiopathic pulmonary fibrosis. A

Externí odkaz: https://doaj.org/article/0781413b03074286b49c5306ce631d9e

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Akademický článek

The bioactivity of soluble Fas ligand is modulated by key amino acids of its stalk region.

Autor: Osamu Kajikawa, Raquel Herrero, Yu-Hua Chow, Chi F Hung, Gustavo Matute-Bello

Publikováno v: PLoS ONE, Vol 16, Iss 6, p e0253260 (2021)

We have previously reported that the 26-amino acid N-terminus stalk region of soluble Fas ligand (sFasL), which is separate from its binding site, is required for its biological function. Here we investigate the mechanisms that link the structure of

Externí odkaz: https://doaj.org/article/d75d1137431f4693ae1775bd8ce25f97

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Akademický článek

Role of integrin alpha8 in murine model of lung fibrosis.

Autor: Chi F Hung, Carole L Wilson, Yu-Hua Chow, Lynn M Schnapp

Publikováno v: PLoS ONE, Vol 13, Iss 5, p e0197937 (2018)

BACKGROUND:Integrin α8 (ITGA8) heterodimerizes with integrin β1 and is highly expressed in stromal cells of the lung. Platelet-derived growth factor receptor beta (PDGFRβ+) cells constitute a major population of contractile myofibroblasts in the l

Externí odkaz: https://doaj.org/article/8b01231e7b2e444bb71299aad641b69e

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Akademický článek

uPARAP function in cutaneous wound repair.

Autor: Maryam G Rohani, Yu-Hua Chow, Maria V Razumova, Samuel Ash, Chi F Hung, Lynn M Schnapp

Publikováno v: PLoS ONE, Vol 9, Iss 3, p e92660 (2014)

Optimal skin wound healing relies on tight balance between collagen synthesis and degradation in new tissue formation and remodeling phases. The endocytic receptor uPARAP regulates collagen uptake and intracellular degradation. In this study we exami

Externí odkaz: https://doaj.org/article/66c2f3b67a3a4a20b455b8e9193366ec

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Akademický článek

Proteomic profiling of bronchoalveolar lavage fluid in critically ill patients with ventilator-associated pneumonia.

Autor: Elizabeth V Nguyen, Sina A Gharib, Steven J Palazzo, Yu-hua Chow, David R Goodlett, Lynn M Schnapp

Publikováno v: PLoS ONE, Vol 8, Iss 3, p e58782 (2013)

Ventilator-associated pneumonia (VAP) is a common complication in patients with acute lung injury (ALI) and can lead to increased morbidity and mortality. Identifying protein profiles specific to VAP in bronchoalveolar lavage fluid (BALF) may aid in

Externí odkaz: https://doaj.org/article/b8b82e3c89db4eedbab88d5e5bf83e55

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Effect of lung pericyte-like cell ablation on the bleomycin model of injury and repair

Autor: Chi F. Hung, Carole L. Wilson, Yu-Hua Chow, Wayne C. Liles, Sina A. Gharib, William A. Altemeier, Lynn M. Schnapp

Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology. 322:L607-L616

We previously showed that pericyte-like cells derived from the FoxD1-lineage contribute to myofibroblasts following bleomycin-induced lung injury. However, their functional significance in lung fibrosis remains unknown. In this study, we used a model

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf4abb058fa7fb5e2c5c4051133d04a4
https://doi.org/10.1152/ajplung.00392.2021

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