Zobrazeno 1 - 10
of 184
pro vyhledávání: '"Yu-Hsun Kao"'
Publikováno v:
iScience, Vol 27, Iss 6, Pp 110084- (2024)
Summary: The mutated SCN5A gene encoding defective Nav1.5 protein causes arrhythmic ailments and is associated with enhanced cardiac fibrosis. This study investigated whether SCN5A mutation directly affects cardiac fibroblasts and explored how defect
Externí odkaz:
https://doaj.org/article/babf76a5971444efb8dba9558936e115
Autor:
Shuen-Hsin Liu, Fong-Jhih Lin, Yu-Hsun Kao, Pao-Huan Chen, Yung-Kuo Lin, Yen-Yu Lu, Yao-Chang Chen, Yi-Jen Chen
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 14, p 7619 (2024)
Sleep deprivation (SD) is a recognized risk factor for atrial fibrillation (AF), yet the precise molecular and electrophysiological mechanisms behind SD-induced AF are unclear. This study explores the electrical and structural changes that contribute
Externí odkaz:
https://doaj.org/article/44200b9fc0c64954adf8f92461a79ff4
Autor:
Hui-Wen Yang, Yi-Hwa Sun, Chih-Yuan Fang, Yoichi Ohiro, Heng-Yi Liao, Yi-Wen Liao, Yu-Hsun Kao, Cheng-Chia Yu
Publikováno v:
Journal of Dental Sciences, Vol 18, Iss 2, Pp 652-658 (2023)
Background/purpose: Oral submucous fibrosis (OSF) is a premalignant disorder that is associated with betel nut chewing. The purpose of the study was to establish the role of histone deacetylase (HDAC) 8, one of histone deacetylases, in the regulation
Externí odkaz:
https://doaj.org/article/2660a8609eb240c3bdc65eff869e22db
Autor:
Cheng-Chih Chung, Yung-Kuo Lin, Yao-Chang Chen, Yu-Hsun Kao, Yung-Hsin Yeh, Nguyen Ngoc Trang, Yi-Jen Chen
Publikováno v:
Cardiovascular Diabetology, Vol 22, Iss 1, Pp 1-15 (2023)
Abstract Background The novel sodium-glucose co-transporter 2 inhibitor (SGLT2i) potentially ameliorates heart failure and reduces cardiac arrhythmia. Cardiac fibrosis plays a pivotal role in the pathophysiology of HF and atrial myopathy, but the eff
Externí odkaz:
https://doaj.org/article/46c75e1a285446bc8d7cd1108b3b3c45
Autor:
Ting-I Lee, Nguyen Ngoc Trang, Ting-Wei Lee, Satoshi Higa, Yu-Hsun Kao, Yao-Chang Chen, Yi-Jen Chen
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 22, p 16142 (2023)
A ketogenic diet (KD) might alleviate patients with diabetic cardiomyopathy. However, the underlying mechanism remains unclear. Myocardial function and arrhythmogenesis are closely linked to calcium (Ca2+) homeostasis. We investigated the effects of
Externí odkaz:
https://doaj.org/article/c35ef4ff702b4bbdb963ab1dcbe83188
Publikováno v:
Journal of the Formosan Medical Association, Vol 121, Iss 10, Pp 2135-2137 (2022)
Externí odkaz:
https://doaj.org/article/20edd359b5f8483abb0fd3ac5fe9e94b
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/fe82cdee6d2c4b0c886299ccde78b4bd
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Calcific aortic valve disease (CAVD) is linked to high mortality. Melatonin inhibits nuclear factor-kappa B (NF-κB)/cyclic AMP response element-binding protein (CREB), contributing to CAVD progression. This study determined the role of melatonin/MT1
Externí odkaz:
https://doaj.org/article/83b5ab5eafd54343a7f7db996b9309af
Publikováno v:
Cells, Vol 12, Iss 9, p 1223 (2023)
Type 2 diabetes mellitus (T2DM) is a global burden, with an increasing number of people affected and increasing treatment costs. The advances in research and guidelines improve the management of blood glucose and related diseases, but T2DM and its co
Externí odkaz:
https://doaj.org/article/c5ee443ae51f412886a7ce99e889e7a5
Publikováno v:
Cells, Vol 12, Iss 6, p 877 (2023)
Background: COVID-19 has a major impact on cardiovascular diseases and may lead to myocarditis or cardiac failure. The clove-like spike (S) protein of SARS-CoV-2 facilitates its transmission and pathogenesis. Cardiac mitochondria produce energy for k
Externí odkaz:
https://doaj.org/article/b786d1d74e8249fa940a1be89e61a325