Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Yu-Hsiu T, Lin"'
Autor:
Neha Paranjape, Yu-Hsiu T. Lin, Quetzal Flores-Ramirez, Vishesh Sarin, Amanda Brooke Johnson, Julia Chu, Mercedes Paredes, Arun P. Wiita
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract 22q11.2 deletion syndrome, associated with congenital and neuropsychiatric anomalies, is the most common copy number variant (CNV)-associated syndrome. Patient-derived, induced pluripotent stem cell (iPS) models have provided insight into th
Externí odkaz:
https://doaj.org/article/e708d96a26e4473194e8958737eff4db
Autor:
Ian D. Ferguson, Bonell Patiño-Escobar, Sami T. Tuomivaara, Yu-Hsiu T. Lin, Matthew A. Nix, Kevin K. Leung, Corynn Kasap, Emilio Ramos, Wilson Nieves Vasquez, Alexis Talbot, Martina Hale, Akul Naik, Audrey Kishishita, Priya Choudhry, Antonia Lopez-Girona, Weili Miao, Sandy W. Wong, Jeffrey L. Wolf, Thomas G. Martin, Nina Shah, Scott Vandenberg, Sonam Prakash, Lenka Besse, Christoph Driessen, Avery D. Posey, R. Dyche Mullins, Justin Eyquem, James A. Wells, Arun P. Wiita
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
The myeloma cell surface proteome regulates plasma cell biology and delineates therapy targets. Here, the authors profile the myeloma surfaceome at baseline and in drug resistance, finding the potential target CCR10, and include a streamlined approac
Externí odkaz:
https://doaj.org/article/c60c92825695486592fb827ec64cf75c
Autor:
Hector H. Huang, Ian D. Ferguson, Alexis M. Thornton, Prabhakar Bastola, Christine Lam, Yu-Hsiu T. Lin, Priya Choudhry, Margarette C. Mariano, Makeba D. Marcoulis, Chin Fen Teo, Julia Malato, Paul J. Phojanakong, Thomas G. Martin, Jeffrey L. Wolf, Sandy W. Wong, Nina Shah, Byron Hann, Angela N. Brooks, Arun P. Wiita
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
The mechanisms of action of proteasome inhibitors (PI) in multiple myeloma (MM) treatment are not fully elucidated. Here, the authors use unbiased phosphoproteomics in PI-treated MM and show increased phosphorylation of splicing-associated proteins,
Externí odkaz:
https://doaj.org/article/9ede6677994c4ad081bb8e902cda0b7a
Autor:
Yu-Hsiu T. Lin, Gregory P. Way, Benjamin G. Barwick, Margarette C. Mariano, Makeba Marcoulis, Ian D. Ferguson, Christoph Driessen, Lawrence H. Boise, Casey S. Greene, Arun P. Wiita
Publikováno v:
Blood Advances, Vol 3, Iss 21, Pp 3214-3227 (2019)
Abstract: A major driver of multiple myeloma (MM) is thought to be aberrant signaling, yet no kinase inhibitors have proven successful in the clinic. Here, we employed an integrated, systems approach combining phosphoproteomic and transcriptome analy
Externí odkaz:
https://doaj.org/article/b53652b0b02e43968b7e68a237b3e8f4
Autor:
Arun P. Wiita, Elliot Stieglitz, Aashish Manglik, Ansuman T. Satpathy, Byron C. Hann, Faranak Fattahi, Veronica Steri, Paul Phojanokong, Anne Deucher, Jonathan Ramirez, Kevin R. Parker, Sagar P. Bapat, Jeffrey D. Whitman, Kristie L. White, Makeba Marcoulis, Jose M. Rivera, Yu-Hsiu T. Lin, Neha Paranjape, Huimin Geng, Kamal Mandal, Matthew A. Nix
Alternative strategies are needed for patients with B-cell malignancy relapsing after CD19-targeted immunotherapy. Here, cell surface proteomics revealed CD72 as an optimal target for poor-prognosis KMT2A/MLL1-rearranged (MLLr) B-cell acute lymphobla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4eda55a5274e3677f255a2fad22066d9
https://doi.org/10.1158/2159-8290.c.6548995.v1
https://doi.org/10.1158/2159-8290.c.6548995.v1
Autor:
Arun P. Wiita, Elliot Stieglitz, Aashish Manglik, Ansuman T. Satpathy, Byron C. Hann, Faranak Fattahi, Veronica Steri, Paul Phojanokong, Anne Deucher, Jonathan Ramirez, Kevin R. Parker, Sagar P. Bapat, Jeffrey D. Whitman, Kristie L. White, Makeba Marcoulis, Jose M. Rivera, Yu-Hsiu T. Lin, Neha Paranjape, Huimin Geng, Kamal Mandal, Matthew A. Nix
Supplementary Data from Surface Proteomics Reveals CD72 as a Target for In Vitro–Evolved Nanobody-Based CAR-T Cells in KMT2A/MLL1-Rearranged B-ALL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::071cd4a9ceee3e0f3be7d0956260a267
https://doi.org/10.1158/2159-8290.22539136.v1
https://doi.org/10.1158/2159-8290.22539136.v1
Autor:
Arun P. Wiita, Elliot Stieglitz, Aashish Manglik, Ansuman T. Satpathy, Byron C. Hann, Faranak Fattahi, Veronica Steri, Paul Phojanokong, Anne Deucher, Jonathan Ramirez, Kevin R. Parker, Sagar P. Bapat, Jeffrey D. Whitman, Kristie L. White, Makeba Marcoulis, Jose M. Rivera, Yu-Hsiu T. Lin, Neha Paranjape, Huimin Geng, Kamal Mandal, Matthew A. Nix
Supplementary Figure from Surface Proteomics Reveals CD72 as a Target for In Vitro–Evolved Nanobody-Based CAR-T Cells in KMT2A/MLL1-Rearranged B-ALL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02d17db5e546d5631791798d1c469ce4
https://doi.org/10.1158/2159-8290.22539127
https://doi.org/10.1158/2159-8290.22539127
Autor:
Cameron Durfee, Nuri Alpay Temiz, Rena Levin-Klein, Prokopios P. Argyris, Lene Alsøe, Sergio Carracedo, Alicia Alonso de la Vega, Joshua Proehl, Anna M. Holzhauer, Zachary J. Seeman, Yu-Hsiu T. Lin, Rachel I. Vogel, Rocio Sotillo, Hilde Nilsen, Reuben S. Harris
Publikováno v:
bioRxiv
SUMMARYThe antiviral DNA cytosine deaminase APOBEC3B has been implicated as a source of mutation in many different cancers. Despite over 10 years of work, a causal relationship has yet to be established between APOBEC3B and any stage of carcinogenesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::682eb7defe301f13f4ecb2994a77c819
https://doi.org/10.1101/2023.02.24.529970
https://doi.org/10.1101/2023.02.24.529970
Autor:
Christine Lam, Ian D. Ferguson, Margarette C. Mariano, Yu-Hsiu T. Lin, Megan Murnane, Hui Liu, Geoffrey A. Smith, Sandy W. Wong, Jack Taunton, Jun O. Liu, Constantine S. Mitsiades, Byron C. Hann, Blake T. Aftab, Arun P. Wiita
Publikováno v:
Haematologica, Vol 103, Iss 7 (2018)
The myeloma bone marrow microenvironment promotes proliferation of malignant plasma cells and resistance to therapy. Activation of JAK/STAT signaling is thought to be a central component of these microenvironment-induced phenotypes. In a prior drug r
Externí odkaz:
https://doaj.org/article/0de808fc838c456d8a047ff83151b7c6
Autor:
Kamal Mandal, Jeffrey D. Whitman, Kevin R. Parker, Elliot Stieglitz, Faranak Fattahi, Aashish Manglik, Jonathan Ramirez, Veronica Steri, Yu-Hsiu T. Lin, Ansuman T. Satpathy, Anne Deucher, Makeba Marcoulis, Matthew A. Nix, Huimin Geng, Paul Phojanokong, Arun P. Wiita, Sagar P. Bapat, Byron Hann, Kristie L. White, Neha Paranjape, Jose M. Rivera
Publikováno v:
Cancer Discovery. 11:2032-2049
Alternative strategies are needed for patients with B-cell malignancy relapsing after CD19-targeted immunotherapy. Here, cell surface proteomics revealed CD72 as an optimal target for poor-prognosis KMT2A/MLL1-rearranged (MLLr) B-cell acute lymphobla