Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Yu-Hsi Lin"'
Autor:
Yasaman Barekatain, Jeffrey J. Ackroyd, Victoria C. Yan, Sunada Khadka, Lin Wang, Ko-Chien Chen, Anton H. Poral, Theresa Tran, Dimitra K. Georgiou, Kenisha Arthur, Yu-Hsi Lin, Nikunj Satani, Elliot S. Ballato, Eliot I. Behr, Ana C. deCarvalho, Roel G. W. Verhaak, John de Groot, Jason T. Huse, John M. Asara, Raghu Kalluri, Florian L. Muller
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
The metabolite methylthioadenosine (MTA) inhibits PRMT5. Therefore, MTA accumulation due to MTA phosphorylase (MTAP) deletion has been proposed as a vulnerability for PRMT5-targeted therapy in cancer. Here, the authors show that MTA does not accumula
Externí odkaz:
https://doaj.org/article/52cd1479712f4a068ae698d7e4c9858e
Autor:
Sunada Khadka, Kenisha Arthur, Yasaman Barekatain, Eliot Behr, Mykia Washington, Jeffrey Ackroyd, Kaitlyn Crowley, Pornpa Suriyamongkol, Yu-Hsi Lin, Cong-Dat Pham, Rafal Zielinski, Marissa Trujillo, James Galligan, Dimitra K. Georgiou, John Asara, Florian Muller
Publikováno v:
Cancer & Metabolism, Vol 9, Iss 1, Pp 1-17 (2021)
Abstract Background Reprogramming of metabolic pathways is crucial to satisfy the bioenergetic and biosynthetic demands and maintain the redox status of rapidly proliferating cancer cells. In tumors, the tricarboxylic acid (TCA) cycle generates biosy
Externí odkaz:
https://doaj.org/article/519bfa2cafdc47bf912b8bcc970dfde2
Autor:
Andrew J. Jezewski, Yu-Hsi Lin, Julie A. Reisz, Rachel Culp-Hill, Yasaman Barekatain, Victoria C. Yan, Angelo D’Alessandro, Florian L. Muller, Audrey R. Odom John
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
Glycolysis controls cellular energy, redox balance, and biosynthesis. Antiglycolytic therapies are under investigation for treatment of obesity, cancer, aging, autoimmunity, and microbial diseases. Interrupting glycolysis is highly valued as a therap
Externí odkaz:
https://doaj.org/article/22d7e09907934e49a2840c1a4cc95da1
Publikováno v:
Shock and Vibration, Vol 2021 (2021)
The 2016 Meinong Earthquake hit southern Taiwan and many shallow foundation structures were damaged due to soil liquefaction. In response, the government initiated an investigation project to construct liquefaction potential maps for metropolitans in
Externí odkaz:
https://doaj.org/article/6926674566f24f16b50a5a549db061c4
Autor:
Mayinuer Maitituoheti, Emily Z. Keung, Ming Tang, Liang Yan, Hunain Alam, Guangchun Han, Anand K. Singh, Ayush T. Raman, Christopher Terranova, Sharmistha Sarkar, Elias Orouji, Samir B. Amin, Sneha Sharma, Maura Williams, Neha S. Samant, Mayura Dhamdhere, Norman Zheng, Tara Shah, Amiksha Shah, Jacob B. Axelrad, Nazanin E. Anvar, Yu-Hsi Lin, Shan Jiang, Edward Q. Chang, Davis R. Ingram, Wei-Lien Wang, Alexander Lazar, Min Gyu Lee, Florian Muller, Linghua Wang, Haoqiang Ying, Kunal Rai
Publikováno v:
Cell Reports, Vol 33, Iss 3, Pp 108293- (2020)
Summary: Histone methyltransferase KMT2D harbors frequent loss-of-function somatic point mutations in several tumor types, including melanoma. Here, we identify KMT2D as a potent tumor suppressor in melanoma through an in vivo epigenome-focused poole
Externí odkaz:
https://doaj.org/article/c36af48cd2dc464096d008d1f2795abf
Autor:
Federica Pisaneschi, Yu-Hsi Lin, Paul G. Leonard, Nikunj Satani, Victoria C. Yan, Naima Hammoudi, Sudhir Raghavan, Todd M. Link, Dimitra K. Georgiou, Barbara Czako, Florian L. Muller
Publikováno v:
Molecules, Vol 24, Iss 13, p 2510 (2019)
We recently reported that SF2312 ((1,5-dihydroxy-2-oxopyrrolidin-3-yl)phosphonic acid), a phosphonate antibiotic with a previously unknown mode of action, is a potent inhibitor of the glycolytic enzyme, Enolase. SF2312 can only be synthesized as a ra
Externí odkaz:
https://doaj.org/article/e2e793ae82144bf6a2f77eea61824b34
Autor:
Nikunj Satani, Yu-Hsi Lin, Naima Hammoudi, Sudhir Raghavan, Dimitra K Georgiou, Florian L Muller
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0168739 (2016)
Inhibition of glycolysis is of great potential for the treatment of cancer. However, inhibitors of glycolytic enzymes with favorable pharmacological profiles have not been forthcoming. Due to the nature of their active sites, most high-affinity trans
Externí odkaz:
https://doaj.org/article/fd28d2bb750f405f8bbc77f0935a40fa
Autor:
Yu-hsi Lin, 林郁喜
106
Polar code is a new type of error-correcting code proposed by E. Arikan in 2009. It is based on channel polarization. The channel capacity of some sub-channels approaches 1; however, others approach 0. And it is proven that the capacity can
Polar code is a new type of error-correcting code proposed by E. Arikan in 2009. It is based on channel polarization. The channel capacity of some sub-channels approaches 1; however, others approach 0. And it is proven that the capacity can
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/87e2zf
Autor:
Yu-Hsi Lin, 林佑錫
100
Debinding is the most important process in the MIM. An improper debinding process will lead to damage in finished products. To analyze the residual saturation and liquid bridge phenomenon among particles in different working parameter, e.g.,
Debinding is the most important process in the MIM. An improper debinding process will lead to damage in finished products. To analyze the residual saturation and liquid bridge phenomenon among particles in different working parameter, e.g.,
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/78720058524834171808
Autor:
Yu-hsi Lin, 林侑羲
97
Most researches on Taiwan''s stock market mainly focus on the relationship with individual industry or with mainland China. This study, however, attempts to view the China concept stocks as a specified industry category and employs the EGARCH
Most researches on Taiwan''s stock market mainly focus on the relationship with individual industry or with mainland China. This study, however, attempts to view the China concept stocks as a specified industry category and employs the EGARCH
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/16136784920049564350