Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Yu-Hong Tan"'
Autor:
Yu-Hong Tan, Vira Tretyachenko-Ladokhina, Xiang Ye, Wei Yang, Y. Morris Chen, Qiang Lu, Donald F. Senear, Ray Luo
Publikováno v:
Biophysical Chemistry. 145:37-44
We have utilized both molecular dynamics simulations and solution biophysical measurements to investigate the rescue mechanism of mutation N235K, which plays a key role in the recently identified global suppressor motif of K235/Y239/R240 in the human
Publikováno v:
The Journal of Physical Chemistry B. 112:7675-7688
We have developed and tested a complete set of nonbonded parameters for a continuum polarizable force field. Our analysis shows that the new continuum polarizable model is consistent with B3LYP/cc-pVTZ in modeling electronic response upon variation o
Publikováno v:
Acta Crystallographica Section D: Biological Crystallography
The impact of hotspot mutation R282Q on the structure of human p53 DNA-binding domain has been characterized by X-ray crystallography and molecular-dynamics simulations.
Tumor suppressor p53 is a sequence-specific DNA-binding protein and its cen
Tumor suppressor p53 is a sequence-specific DNA-binding protein and its cen
Publikováno v:
The Journal of Physical Chemistry B. 111:11538-11545
We have studied room-temperature structural and dynamic properties of the p53 DNA-binding domain in both DNA-bound and DNA-free states. A cumulative 55 ns of explicit solvent molecular dynamics simulations with the particle mesh Ewald treatment of el
Autor:
P. Z. Ning, Yu-Hong Tan
Publikováno v:
Europhysics Letters (EPL). 67:355-361
We investigate the properties of heavy flavored baryon hypernuclei (i.e., Λc+, Λb, Ξc+ and Ξc0 hypernuclei) within the framework of the relativistic mean-field model. It is found that no Λc+ or Ξc+ bound states could exist if the potential well
Publikováno v:
Communications in Theoretical Physics. 37:215-220
The K+ scattering cross section with the in-medium virtual pion is evaluated in the lowest-order chiral perturbation theory with the density-dependent pion decay constant and mass. The contribution of nuclear pions to the total K+-nucleus cross secti
Autor:
Jun Cao, Dao-yuan Tu, Jie Zhou, Guo-qing Jiang, Sheng-jie Jin, Bing-bing Su, Hao Tang, Yu-hong Tang, Ao-qing Wang, Qian Wang, Ren-jie Liu, Chi Zhang, Dou-sheng Bai
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The membrane‐associated RING‐CH (MARCH) family, a member of the E3 ubiquitin ligases, has been confirmed by a growing number of studies to be associated with immune function and has been highlighted as a potential immunotherapy target. In our res
Externí odkaz:
https://doaj.org/article/45f8600002524d45a8a1dc922829dec4
Autor:
Ray Luo, Yu-Hong Tan
Publikováno v:
PMC biophysics, vol 2, iss 1
PMC Biophysics
PMC Biophysics
Most human cancers contain mutations in the transcription factor p53 and majority of these are missense and located in the DNA binding core domain. In this study, the stabilities of all core domain missense mutations are predicted and are used to inf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45b4b38ee8db5fff21c8eeb384dab362
https://escholarship.org/uc/item/3ff0j4vc
https://escholarship.org/uc/item/3ff0j4vc
Autor:
Yu-Hong Tan, Ray Luo
Publikováno v:
The journal of physical chemistry. B. 112(6)
Most proteins are only marginally stable at physiological temperatures. Thus a common defect due to mutation is the loss of protein stability, resulting in loss of their well-defined structures and functions at their functioning temperatures. Quantif
Publikováno v:
The journal of physical chemistry. B. 111(42)
We have systematically analyzed a new nonpolar solvent model that separates nonpolar solvation free energy into repulsive and attractive components. Our analysis shows that either molecular surfaces or volumes can be used to correlate with repulsive