Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Yu-Fen Chou"'
Autor:
Hsu-Hsin Chen, Maaike Welling, Donald B. Bloch, Javier Muñoz, Edwin Mientjes, Xinjie Chen, Cody Tramp, Jie Wu, Akiko Yabuuchi, Yu-Fen Chou, Christa Buecker, Adrian Krainer, Rob Willemsen, Albert J. Heck, Niels Geijsen
Publikováno v:
Stem Cell Reports, Vol 3, Iss 5, Pp 892-904 (2014)
The scarcity of primordial germ cells (PGCs) in the developing mammalian embryo hampers robust biochemical analysis of the processes that underlie early germ cell formation. Here, we demonstrate that DAZL, a germ cell-specific RNA binding protein, is
Externí odkaz:
https://doaj.org/article/25751e2151664c4a85e351f61e3f039b
Publikováno v:
Connective Tissue Research. 52:119-132
Although recent studies have proposed that human adipose-derived stem cells (ASCs), together with BMP2, can heal critical-sized bony defects, a companion study in this issue suggests that ASCs may not respond to BMP2 in vivo. To examine why this may
Autor:
Niels Geijsen, Josh G. Chenoweth, Jun Lu, Maureen Eijpe, Paul J. Tesar, Ronald D.G. McKay, Yu-Fen Chou, Hsu-Hsin Chen, Akiko Yabuuchi
Publikováno v:
Cell. 135:449-461
SummaryPluripotent stem cell lines can be derived from blastocyst embryos, which yield embryonic stem cell lines (ES cells), as well as the postimplantation epiblast, which gives rise to epiblast stem cell lines (EpiSCs). Remarkably, ES cells and Epi
Autor:
Yu-Fen Chou, Benjamin Walder, Kang Ting, Xinli Zhang, Catherine M. Cowan, Chia Soo, Benjamin M. Wu, Tara Aghaloo
Publikováno v:
Tissue Engineering. 13:501-512
Numerous growth factors, peptides, and small molecules are being developed for bone tissue engineering. The optimal dosing, stability, and bioactivity of these biological molecules are likely influenced by the carrier biomaterial. Efficient evaluatio
Autor:
Haofu Lee, Xinli Zhang, Nichole Hong, Tara Aghaloo, Shun'ichi Kuroda, Benjamin M. Wu, Catherine M. Cowan, Steve Miao, Yu-Fen Chou, Chia Soo, Kang Ting
Publikováno v:
The American Journal of Pathology. 169:903-915
Many craniofacial birth defects contain skeletal components requiring bone grafting. We previously identified the novel secreted osteogenic molecule NELL-1, first noted to be overexpressed during premature bone formation in calvarial sutures of crani
Publikováno v:
Biomaterials. 26:285-295
The conventional biomimetic apatite coating process can be accelerated by immersing substrates into concentrated simulated body fluid (5 x SBF) at 37 degrees C to form an initial coating of apatite precursor spheres, and transform the precursors into
Autor:
Carina Mari, Catherine M. Cowan, Yun-Ying Shi, Natalina Quarto, Michael T. Longaker, Romy Thomas, Christopher H. Contag, Yu-Fen Chou, Oliver Aalami, Benjamin M. Wu
Publikováno v:
Nature Biotechnology. 22:560-567
In adults and children over two years of age, large cranial defects do not reossify successfully, posing a substantial biomedical burden. The osteogenic potential of bone marrow stromal (BMS) cells has been documented. This study investigates the in
Autor:
Yu-Fen Chou, Akiko Yabuuchi
Publikováno v:
Current Protocols in Toxicology
The derivation of embryonic stem (ES) cells represents one of the most important breakthroughs in mammalian developmental biology. In addition to their utility in a wide array of in vitro studies, ES cells are also one of the most useful starting mat
Publikováno v:
Connective tissue research. 52(2)
Recombinant human bone morphogenetic protein-2 (rhBMP2) has been shown to induce both in vitro osteogenic differentiation and in vivo bone formation, with the capacity of rhBMP2 to elicit the repair of numerous bony defects (calvaria, spinal fusion,
Autor:
Helen M. Blau, Lisa J. Brunet, Yu-Fen Chou, Jae-Beom Kim, Benjamin M. Wu, Michael T. Longaker, Derrick C. Wan, Jason H. Pomerantz, Richard M. Harland
Publikováno v:
The Journal of biological chemistry. 282(36)
Several investigations have demonstrated a precise balance to exist between bone morphogenetic protein (BMP) agonists and antagonists, dictating BMP signaling and osteogenesis. We report a novel approach to manipulate BMP activity through a down-regu