Zobrazeno 1 - 10 of 49 pro vyhledávání: '"Yu-Chin Lien"'
1
Akademický článek
SPAG7 deletion causes intrauterine growth restriction, resulting in adulthood obesity and metabolic dysfunction
Autor: Stephen E Flaherty III, Olivier Bezy, Brianna LaCarubba Paulhus, LouJin Song, Mary Piper, Jincheng Pang, Yoson Park, Shoh Asano, Yu-Chin Lien, John D Griffin, Andrew Robertson, Alan Opsahl, Dinesh Hirenallur Shanthappa, Youngwook Ahn, Evanthia Pashos, Rebecca A Simmons, Morris J Birnbaum, Zhidan Wu
Publikováno v: eLife, Vol 12 (2024)
From a forward mutagenetic screen to discover mutations associated with obesity, we identified mutations in the Spag7 gene linked to metabolic dysfunction in mice. Here, we show that SPAG7 KO mice are born smaller and develop obesity and glucose into
Externí odkaz: https://doaj.org/article/4c48137f953943ab9ab7d2ee4fda5031
Zobrazit plný text záznamu
2
Akademický článek
Intrauterine Inflammation Alters the Transcriptome and Metabolome in Placenta
Autor: Yu-Chin Lien, Zhe Zhang, Guillermo Barila, Amy Green-Brown, Michal A. Elovitz, Rebecca A. Simmons
Publikováno v: Frontiers in Physiology, Vol 11 (2020)
Placental insufficiency is implicated in spontaneous preterm birth (SPTB) associated with intrauterine inflammation. We hypothesized that intrauterine inflammation leads to deficits in the capacity of the placenta to maintain bioenergetic and metabol
Externí odkaz: https://doaj.org/article/972fa3705d1d461b8b5f99fd54f7ef90
Zobrazit plný text záznamu
3
Akademický článek
Defiant: (DMRs: easy, fast, identification and ANnoTation) identifies differentially Methylated regions from iron-deficient rat hippocampus
Autor: David E. Condon, Phu V. Tran, Yu-Chin Lien, Jonathan Schug, Michael K. Georgieff, Rebecca A. Simmons, Kyoung-Jae Won
Publikováno v: BMC Bioinformatics, Vol 19, Iss 1, Pp 1-12 (2018)
Abstract Background Identification of differentially methylated regions (DMRs) is the initial step towards the study of DNA methylation-mediated gene regulation. Previous approaches to call DMRs suffer from false prediction, use extreme resources, an
Externí odkaz: https://doaj.org/article/844f63a9e4c34a6f8da4fceb6e44810e
Zobrazit plný text záznamu
4
Akademický článek
Altered Transcription Factor Binding and Gene Bivalency in Islets of Intrauterine Growth Retarded Rats
Autor: Yu-Chin Lien, Paul Zhiping Wang, Xueqing Maggie Lu, Rebecca A. Simmons
Publikováno v: Cells, Vol 9, Iss 6, p 1435 (2020)
Intrauterine growth retardation (IUGR), which induces epigenetic modifications and permanent changes in gene expression, has been associated with the development of type 2 diabetes. Using a rat model of IUGR, we performed ChIP-Seq to identify and map
Externí odkaz: https://doaj.org/article/d119da29296b41d3bc1a22378a5c89db
Zobrazit plný text záznamu
7
Data from Phospholipase C-δ1 Is a Critical Target for Tumor Necrosis Factor Receptor–Mediated Protection against Adriamycin-Induced Cardiac Injury
Autor: Daret K. St. Clair, Kuey-Chu Chen, Arnold J. Stromberg, Hua Liu, Teresa Noel, Yu-Chin Lien
The clinical application of adriamycin, an exceptionally good chemotherapeutic agent, is limited by its dose-related cardiomyopathy. Our recent study showed that tumor necrosis factor-α (TNF-α) receptors mediated cytoprotective signaling against ad
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::218a7135243260828ce9b1343f4e2df9
https://doi.org/10.1158/0008-5472.c.6495113
Zobrazit plný text záznamu
8
Identification of Novel Regulatory Regions Induced by Intrauterine Growth Restriction in Rat Islets
Autor: Yu-Chin Lien, Sara E Pinney, Xueqing Maggie Lu, Rebecca A Simmons
Publikováno v: Endocrinology
Intrauterine growth restriction (IUGR) leads to the development of type 2 diabetes in adulthood, and the permanent alterations in gene expression implicate an epigenetic mechanism. Using a rat model of IUGR, we performed TrueSeq-HELP Tagging to asses
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bdf8ee2f10ada6dc9ec6e2fdc99f61d
https://europepmc.org/articles/PMC8743043/
Zobrazit plný text záznamu
9
Human Placental Transcriptome Reveals Critical Alterations in Inflammation and Energy Metabolism with Fetal Sex Differences in Spontaneous Preterm Birth
Autor: Harry Ischiropoulos, Yi Cheng, Samuel Parry, Laura Sillers, Erzsebet Polyak, Rebecca A. Simmons, Zhe Zhang, Marni J. Falk, Yu-Chin Lien
Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 15
International Journal of Molecular Sciences, Vol 22, Iss 7899, p 7899 (2021)
A well-functioning placenta is crucial for normal gestation and regulates the nutrient, gas, and waste exchanges between the maternal and fetal circulations and is an important endocrine organ producing hormones that regulate both the maternal and fe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ee23301318468e9e7257d6d2afffdfd
http://europepmc.org/articles/PMC8347496
Zobrazit plný text záznamu
10
The Transcriptome and Epigenome Reveal Novel Changes in Transcription Regulation During Pancreatic Rat Islet Maturation
Autor: Wendy Osei-Bonsu, Rebecca A. Simmons, Kyoung-Jae Won, Paul Zhiping Wang, Xueqing Maggie Lu, Yu-Chin Lien
Publikováno v: Endocrinology. 162(11)
Islet function is critical for normal glucose homeostasis. Unlike adult β cells, fetal and neonatal islets are more proliferative and have decreased insulin secretion in response to stimuli. However, the underlying mechanisms governing functional ma
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62a1c967eafc8023945a59052cef16f5
https://pubmed.ncbi.nlm.nih.gov/34849676
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje