Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Yu Togashi"'
Autor:
Yu Togashi, Daisuke Miyashita, Takahiro Tsuno, Ryota Inoue, Tomoko Okuyama, Mayu Kyohara, Kuniyuki Nishiyama, Masanori Arai, Kenta Kanematsu, Soichiro Kanataki, Yasuo Terauchi, Jun Shirakawa
Publikováno v:
Journal of Diabetes Investigation, Vol 13, Iss 11, Pp 1861-1872 (2022)
Abstract Aims/Introduction This study aimed to clarify the nature of the relationship between the abdominal aortic calcification (AAC) grade and the presence of cardiovascular diseases, and determine factors related to AAC grade in people with type 2
Externí odkaz:
https://doaj.org/article/e59f7325f10a4e7e9c8b470c89defc7a
Autor:
Jun Shirakawa, Yu Togashi, Giorgio Basile, Tomoko Okuyama, Ryota Inoue, Megan Fernandez, Mayu Kyohara, Dario F. De Jesus, Nozomi Goto, Wei Zhang, Takahiro Tsuno, Tatsuya Kin, Hui Pan, Jonathan M. Dreyfuss, A.M. James Shapiro, Peng Yi, Yasuo Terauchi, Rohit N. Kulkarni
Publikováno v:
Cell Reports, Vol 41, Iss 1, Pp 111436- (2022)
Summary: Prevention or amelioration of declining β cell mass is a potential strategy to cure diabetes. Here, we report the pathways utilized by β cells to robustly replicate in response to acute insulin resistance induced by S961, a pharmacological
Externí odkaz:
https://doaj.org/article/3143a9f198114e48a593ab4fa7acda69
Autor:
Masanori Hasebe, Jun Shirakawa, Daisuke Miyashita, Rieko Kunishita, Mayu Kyohara, Tomoko Okuyama, Yu Togashi, Yasuo Terauchi
Publikováno v:
Journal of Medical Case Reports, Vol 15, Iss 1, Pp 1-6 (2021)
Abstract Background Syndrome of inappropriate antidiuretic hormone secretion can be caused by arginine-vasopressin-producing tumors or enhanced arginine vasopressin secretion from the posterior pituitary gland due to central nervous system disorders
Externí odkaz:
https://doaj.org/article/a1a48c26da1a499390f5aa2b3167b2ad
Autor:
Ryota Inoue, Takahiro Tsuno, Yu Togashi, Tomoko Okuyama, Aoi Sato, Kuniyuki Nishiyama, Mayu Kyohara, Jinghe Li, Setsuko Fukushima, Tatsuya Kin, Daisuke Miyashita, Yusuke Shiba, Yoshitoshi Atobe, Hiroshi Kiyonari, Kana Bando, A.M. James Shapiro, Kengo Funakoshi, Rohit N. Kulkarni, Yasuo Terauchi, Jun Shirakawa
Publikováno v:
iScience, Vol 25, Iss 7, Pp 104603- (2022)
Summary: Uncoupling protein 2 (UCP2), a mitochondrial protein, is known to be upregulated in pancreatic islets of patients with type 2 diabetes (T2DM); however, the pathological significance of this increase in UCP2 expression is unclear. In this stu
Externí odkaz:
https://doaj.org/article/749f21feddc94cc29bd880275707990e
Autor:
Tomoko Okuyama, Jun Shirakawa, Takashi Nakamura, Takayo Murase, Daisuke Miyashita, Ryota Inoue, Mayu Kyohara, Yu Togashi, Yasuo Terauchi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Xanthine oxidoreductase (XOR) catalyzes the oxidation of hypoxanthine to xanthine, and of xanthine to uric acid. XOR also enhances the production of reactive oxygen species and causes endothelial dysfunction. In this study, we evaluated the
Externí odkaz:
https://doaj.org/article/87d7f33d032f4a0a800350751de49494
Autor:
Mayu Kyohara, Daisuke Miyashita, Ryota Inoue, Kuniyuki Nishiyama, Takahiro Tsuno, Tomoko Okuyama, Yu Togashi, Yasuo Terauchi, Jun Shirakawa
Publikováno v:
PLoS ONE, Vol 17, Iss 11, p e0276915 (2022)
Plasma and liver SerpinB1 levels are elevated in mice with insulin resistance and promote β-cell proliferation in human islets. We measured serum SerpinB1 levels in Japanese subjects with or without type 2 diabetes (T2DM). We enrolled 12 normal gluc
Externí odkaz:
https://doaj.org/article/cfa0caa090024e18b76b70c9cbb9465b
Autor:
Mayu Kyohara, Jun Shirakawa, Tomoko Okuyama, Yu Togashi, Ryota Inoue, Jinghe Li, Daisuke Miyashita, Yasuo Terauchi
Publikováno v:
Diabetology & Metabolic Syndrome, Vol 12, Iss 1, Pp 1-13 (2020)
Abstract Background Insulin resistance can occur in all metabolic organs including the liver, adipose tissue, and skeletal muscles. Circulating soluble epidermal growth factor receptor (soluble EGFR) and adipsin levels are altered in obese diabetic m
Externí odkaz:
https://doaj.org/article/6433379bdd8542cf8ffa586baa7d3528
Autor:
Kazuki Tajima, Jun Shirakawa, Yu Togashi, Shunsuke Yamazaki, Tomoko Okuyama, Mayu Kyohara, Hiromi Konishi, Yasuo Terauchi
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract Growth factor signaling via insulin receptor (IR) and IGF-1 receptor (IGF1R) plays several important roles in the pathogenesis of metabolic syndrome and diabetes. OSI-906 (linsitinib), an anti-tumor drug, is an orally bioavailable dual inhib
Externí odkaz:
https://doaj.org/article/09a9086494a640ca8284695f8b491659
Autor:
Tomoko Okuyama, Jun Shirakawa, Hiromi Yanagisawa, Mayu Kyohara, Shunsuke Yamazaki, Kazuki Tajima, Yu Togashi, Yasuo Terauchi
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Glucokinase-mediated glucose signaling induces insulin secretion, proliferation, and apoptosis in pancreatic β-cells. However, the precise molecular mechanisms underlying these processes are not clearly understood. Here, we demonstrated tha
Externí odkaz:
https://doaj.org/article/2101103c43844a20b6c04abcf16cd35b
Autor:
Tomoko Okuyama, Jun Shirakawa, Kazuki Tajima, Yoko Ino, Heidrun Vethe, Yu Togashi, Mayu Kyohara, Ryota Inoue, Daisuke Miyashita, Jinghe Li, Nozomi Goto, Taiga Ichikawa, Shingo Yamasaki, Haruka Ohnuma, Rie Takayanagi, Yayoi Kimura, Hisashi Hirano, Yasuo Terauchi
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 21, p 7815 (2020)
Abnormal hepatic insulin signaling is a cause or consequence of hepatic steatosis. DPP-4 inhibitors might be protective against fatty liver. We previously reported that the systemic inhibition of insulin receptor (IR) and IGF-1 receptor (IGF1R) by th
Externí odkaz:
https://doaj.org/article/3053b0f8858144a997f112afaac9d3fb