Zobrazeno 1 - 10
of 436
pro vyhledávání: '"Yu Tian Wang"'
Autor:
Yuxin Chen, Xiaohuan Li, Qian Xiong, Yehong Du, Man Luo, Lilin Yi, Yayan Pang, Xiuyu Shi, Yu Tian Wang, Zhifang Dong
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-18 (2023)
Abstract Background The nucleotide-binding oligomeric domain (NOD)-like receptor protein 3 (NLRP3) inflammasome is believed to be a key mediator of neuroinflammation and subsequent secondary brain injury induced by ischemic stroke. However, the role
Externí odkaz:
https://doaj.org/article/84d1f759cb4d4ccbbf6c8f9e1023baa1
Autor:
Tao Ma, Lei Wang, Anping Chai, Chao Liu, Wenqiang Cui, Shuguang Yuan, Shannon Wing Ngor Au, Liang Sun, Xiaokang Zhang, Zhenzhen Zhang, Jianping Lu, Yuanzhu Gao, Peiyi Wang, Zhifang Li, Yujie Liang, Horst Vogel, Yu Tian Wang, Daping Wang, Kaige Yan, Huawei Zhang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract ClC-2 transports chloride ions across plasma membranes and plays critical roles in cellular homeostasis. Its dysfunction is involved in diseases including leukodystrophy and primary aldosteronism. AK-42 was recently reported as a specific in
Externí odkaz:
https://doaj.org/article/1b44828fd4bb481d8c3c6800caa356fb
Autor:
Ya Wen, Zhifang Dong, Jun Liu, Peter Axerio-Cilies, Yehong Du, Junjie Li, Long Chen, Lu Zhang, Lidong Liu, Jie Lu, Ning Zhou, Dong Chuan Wu, Yu Tian Wang
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 7, Iss 1, Pp 1-18 (2022)
Abstract Maintaining a proper balance between the glutamate receptor-mediated neuronal excitation and the A type of GABA receptor (GABAAR) mediated inhibition is essential for brain functioning; and its imbalance contributes to the pathogenesis of ma
Externí odkaz:
https://doaj.org/article/133ea9a75bc840049467928b191b5e7f
Autor:
Yehong Du, Junjie Li, Maoju Wang, Qiuyun Tian, Yayan Pang, Ya Wen, Dongchuan Wu, Yu Tian Wang, Zhifang Dong
Publikováno v:
MedComm, Vol 4, Iss 3, Pp n/a-n/a (2023)
Abstract The imbalance between neuronal excitation and inhibition (E/I) in neural circuit has been considered to be at the root of numerous brain disorders. We recently reported a novel feedback crosstalk between the excitatory neurotransmitter gluta
Externí odkaz:
https://doaj.org/article/960e7357f21c40f4979af4b90801540e
Autor:
Yang Ge, Yu Tian Wang
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Glutamate N-methyl-D-aspartate receptor (NMDAR) is critical for promoting physiological synaptic plasticity and neuronal viability. As a major subpopulation of the NMDAR, the GluN2B subunit-containing NMDARs have distinct pharmacological properties,
Externí odkaz:
https://doaj.org/article/a09fd18dccd14076a1036d7a10a71699
Autor:
Shreya H Dhume, Steven A Connor, Fergil Mills, Parisa Karimi Tari, Sarah HM Au-Yeung, Benjamin Karimi, Shinichiro Oku, Reiko T Roppongi, Hiroshi Kawabe, Shernaz X Bamji, Yu Tian Wang, Nils Brose, Michael F Jackson, Ann Marie Craig, Tabrez J Siddiqui
Publikováno v:
eLife, Vol 11 (2022)
LRRTMs are postsynaptic cell adhesion proteins that have region-restricted expression in the brain. To determine their role in the molecular organization of synapses in vivo, we studied synapse development and plasticity in hippocampal neuronal circu
Externí odkaz:
https://doaj.org/article/34f1f7432bce4e58b14dc493955892e7
Autor:
Jack Wuyang Jin, Xuelai Fan, Esther del Cid-Pellitero, Xing-Xing Liu, Limin Zhou, Chunfang Dai, Ebrima Gibbs, Wenting He, Hongjie Li, Xiaobin Wu, Austin Hill, Blair R. Leavitt, Neil Cashman, Lidong Liu, Jie Lu, Thomas M. Durcan, Zhifang Dong, Edward A. Fon, Yu Tian Wang
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Jin et al develop and characterise a blood-brain barrier and plasma membrane-permeable α-synuclein knockdown peptide, Tat-βsyn-degron. In two mouse models of Parkinson’s disease, they show that Tat-βsyn-degron decreases α-synuclein aggregates a
Externí odkaz:
https://doaj.org/article/63d676340fd343489fc159532b920ece
Autor:
Donovan M. Ashby, Stan B. Floresco, Anthony G. Phillips, Alexander McGirr, Jeremy K. Seamans, Yu Tian Wang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
LTP and LTD are involved in shaping hippocampal place field representations. Here, the authors show that de novo pathway-specific hippocampal LTD changes dynamics and stability of newly formed place fields, regulating acquisition and maintenance of n
Externí odkaz:
https://doaj.org/article/7955892d980e42c28d73f7ce2fa36609
Publikováno v:
Molecular Brain, Vol 13, Iss 1, Pp 1-16 (2020)
Abstract Accumulating evidence implicates dysregulation of hippocampal synaptic plasticity in the pathophysiology of depression. However, the effects of ketamine on synaptic plasticity and their contribution to its mechanism of action as an antidepre
Externí odkaz:
https://doaj.org/article/303462df672147209a6fc49f5b4f2612
Autor:
Yun-Fei Bai, Michelle Chiu, Elizabeth S. Chan, Peter Axerio-Cilies, Jie Lu, Linda Huh, Mary B. Connolly, Ilaria Guella, Matthew J. Farrer, Zhi-Qing David Xu, Lidong Liu, Michelle Demos, Yu Tian Wang
Publikováno v:
Molecular Brain, Vol 12, Iss 1, Pp 1-17 (2019)
Abstract We report the identification of a de novo GABRA1 (R214C) variant in a child with epileptic encephalopathy (EE), describe its functional characterization and pathophysiology, and evaluate its potential therapeutic options. The GABRA1 (R214C)
Externí odkaz:
https://doaj.org/article/05079710b492409489c8147725986750