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Generic approach for the discovery of drug metabolites in horses based on data-dependent acquisition by liquid chromatography high-resolution mass spectrometry and its applications to pharmacokinetic study of daprodustat

Autor: Hideaki Ishii, Mariko Shibuya, Kanichi Kusano, Yu Sone, Takahiro Kamiya, Ai Wakuno, Hideki Ito, Kenji Miyata, Fumio Sato, Taisuke Kuroda, Masayuki Yamada, Gary Ngai-Wa Leung

Publikováno v: Analytical and Bioanalytical Chemistry. 414:8125-8142

In drug metabolism studies in horses, non-targeted analysis by means of liquid chromatography coupled with high-resolution mass spectrometry with data-dependent acquisition (DDA) has recently become increasingly popular for rapid identification of po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::708b1df2fece21db1b1248f4c59e55a5
https://doi.org/10.1007/s00216-022-04347-2

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Comprehensive metabolic study of IOX4 in equine urine and plasma using liquid chromatography/electrospray ionization Q Exactive high‐resolution mass spectrometer for the purpose of doping control

Autor: Jenny K.Y. Wong, Yat-Ming So, Kanichi Kusano, Yu Sone, Masayuki Yamada, Takahiro Kamiya, Emmie N.M. Ho, Hideaki Ishii, Ai Wakuno, Hideki Ito, Mariko Shibuya, Gary Ngai-Wa Leung, Kenji Miyata

Publikováno v: Drug Testing and Analysis. 14:233-251

IOX4 is a hypoxia-inducible factor prolyl hydroxylase (HIF-PHD) inhibitor, which was developed for the treatment of anemia by exerting hematopoietic effects. The administration of HIF-PHD inhibitors such as IOX4 to horses is strictly prohibited by th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30447b32ff75c15c6dafbe05b516909f
https://doi.org/10.1002/dta.3172

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Pharmacokinetic Study of Vadadustat and High-Resolution Mass Spectrometric Characterization of its Novel Metabolites in Equines for the Purpose of Doping Control

Autor: Hideaki Ishii, Mariko Shibuya, Kanichi Kusano, Yu Sone, Takahiro Kamiya, Ai Wakuno, Hideki Ito, Kenji Miyata, Fumio Sato, Taisuke Kuroda, Masayuki Yamada, Gary Ngai-Wa Leung

Publikováno v: Current drug metabolism. 23(10)

Background: Vadadustat, a hypoxia-inducible factor prolyl hydroxylase (HIF-PHD) inhibitor, is a substance which carries a lifetime ban in both horse racing and equestrian competition. A comprehensive metabolic study of vadadustat in horses has not be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::230f7f06f6ebb54032da7bb791996d7e
https://pubmed.ncbi.nlm.nih.gov/36017833

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