Zobrazeno 1 - 10
of 108
pro vyhledávání: '"Yu Sakurai"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Diesel exhaust particles (DEPs) are very small (typically
Externí odkaz:
https://doaj.org/article/9975952815a844ebb44be209ad10c198
Autor:
Jessica Anindita, Hiroki Tanaka, Takuma Yamakawa, Yuka Sato, Chika Matsumoto, Kota Ishizaki, Taiji Oyama, Satoko Suzuki, Keisuke Ueda, Kenjirou Higashi, Kunikazu Moribe, Kasumi Sasaki, Yumika Ogura, Etsuo Yonemochi, Yu Sakurai, Hiroto Hatakeyama, Hidetaka Akita
Publikováno v:
Pharmaceutics, Vol 16, Iss 2, p 181 (2024)
RNA vaccines are applicable to the treatment of various infectious diseases via the inducement of robust immune responses against target antigens by expressing antigen proteins in the human body. The delivery of messenger RNA by lipid nanoparticles (
Externí odkaz:
https://doaj.org/article/feed0d958f87451c976c7bf4c45b7418
Autor:
Jessica Anindita, Hiroki Tanaka, Ryotaro Oyama, Shinya Hagiwara, Daiki Shirane, Sakura Taneichi, Yuta Nakai, Kota Tange, Hiroto Hatakeyama, Yu Sakurai, Hidetaka Akita
Publikováno v:
Pharmaceutics, Vol 15, Iss 12, p 2702 (2023)
Because of its efficient and robust gene transfer capability, messenger RNA (mRNA) has become a promising tool in various research fields. The lipid nanoparticle (LNP) is considered to be a fundamental technology for an mRNA delivery system and has b
Externí odkaz:
https://doaj.org/article/928e771d58a540ed8ba2ff73efc70014
Autor:
Masaki Gomi, Yuka Nakayama, Yu Sakurai, Ryotaro Oyama, Koki Iwasaki, Mizuki Doi, Yi Liu, Mizuho Hori, Himeka Watanabe, Kohei Hashimoto, Hiroki Tanaka, Kota Tange, Yuta Nakai, Hidetaka Akita
Publikováno v:
Pharmaceuticals, Vol 16, Iss 9, p 1270 (2023)
Multiple sclerosis is a disease caused by autoantigen-responsive immune cells that disrupt the myelin in the central nervous system (CNS). Although immunosuppressive drugs are used to suppress symptoms, no definitive therapy exists. As in the experim
Externí odkaz:
https://doaj.org/article/c8e2dc1066954f429292f5e51e38472b
Autor:
Daiki Shirane, Hiroki Tanaka, Yu Sakurai, Sakura Taneichi, Yuta Nakai, Kota Tange, Itsuko Ishii, Hidetaka Akita
Publikováno v:
Pharmaceutics, Vol 15, Iss 7, p 1819 (2023)
The lipid nanoparticle (LNP) is one of the promising nanotechnologies for the delivery of RNA molecules, such as small interfering RNA (siRNA) and messenger RNA (mRNA). A series of LNPs that contain an mRNA encoding the antigen protein of SARS-CoV-2
Externí odkaz:
https://doaj.org/article/a7474de252654456bfef9cf26ae6de09
Autor:
Yu Sakurai, Himeka Watanabe, Kazuma Nishio, Kohei Hashimoto, Atsuki Harada, Masaki Gomi, Masayoshi Suzuki, Ryotaro Oyama, Takumi Handa, Risa Sato, Hina Takeuchi, Ryoga Taira, Kenta Tezuka, Kota Tange, Yuta Nakai, Hidetaka Akita, Yasuo Uchida
Publikováno v:
Pharmaceutics, Vol 14, Iss 8, p 1560 (2022)
The blood–brain barrier (BBB), which is comprised of brain capillary endothelial cells, plays a pivotal role in the transport of drugs from the blood to the brain. Therefore, an analysis of proteins in the endothelial cells, such as transporters an
Externí odkaz:
https://doaj.org/article/8ef28c83ac23478d96d8b2a64e93136b
Publikováno v:
Molecular Therapy: Oncolytics, Vol 11, Iss , Pp 102-108 (2018)
Although metastatic cancer is a major cause of death for cancer patients, no efficacious treatment for metastasis is available. We previously showed that the growth of a primary tumor could be inhibited by the administration of an anti-angiogenic sma
Externí odkaz:
https://doaj.org/article/47529792c9c14eeba0af005a3de4feab
Autor:
Hiroki Tanaka, Ryo Miyama, Yu Sakurai, Shinya Tamagawa, Yuta Nakai, Kota Tange, Hiroki Yoshioka, Hidetaka Akita
Publikováno v:
Pharmaceutics, Vol 13, Iss 12, p 2097 (2021)
(1) Background: T cells are important target cells, since they exert direct cytotoxic effects on infected/malignant cells, and affect the regulatory functions of other immune cells in a target antigen-specific manner. One of the current approaches fo
Externí odkaz:
https://doaj.org/article/dd8bd9318b14419e841f43ab5e4c4e99
Publikováno v:
Pharmaceutics, Vol 13, Iss 9, p 1462 (2021)
The sentinel lymph node (SLN) is the first lymph node into which lymphatic fluid from tumor tissues flows. The development of a highly sensitive probe for detecting SLNs is desired for the lymph node dissection through intraoperative biopsy. We have
Externí odkaz:
https://doaj.org/article/b3ecef3396534a2c959cb2726334bcf9
Autor:
Hiroki Tanaka, Nae Takata, Yu Sakurai, Tokuyuki Yoshida, Takao Inoue, Shinya Tamagawa, Yuta Nakai, Kota Tange, Hiroki Yoshioka, Masatoshi Maeki, Manabu Tokeshi, Hidetaka Akita
Publikováno v:
Pharmaceutics, Vol 13, Iss 4, p 544 (2021)
The world-first success of lipid nanoparticle (LNP)-based siRNA therapeutics (ONPATTRO®) promises to accelerate developments in siRNA therapeutics/gene therapy using LNP-type drug delivery systems (DDS). In this study, we explore the optimal composi
Externí odkaz:
https://doaj.org/article/30d57eeba6e3433dadd085df9e3458c3