Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Yu Ru V. Shih"'
Autor:
Yu‐Ru V. Shih, David Kingsley, Hunter Newman, Jiaul Hoque, Ankita Gupta, B. Duncan X. Lascelles, Shyni Varghese
Publikováno v:
Advanced Science, Vol 10, Iss 36, Pp n/a-n/a (2023)
Abstract Bone injuries such as fractures are one major cause of morbidities worldwide. A considerable number of fractures suffer from delayed healing, and the unresolved acute pain may transition to chronic and maladaptive pain. Current management of
Externí odkaz:
https://doaj.org/article/5f86029c39164ce89910eacc064a00c7
Autor:
Hunter Newman, Jiaul Hoque, Yu-Ru V. Shih, Gabrielle Marushack, Unghyeon Ko, Gavin Gonzales, Shyni Varghese
Publikováno v:
Biomaterials science. 10(18)
pH-Sensitive nanocarriers deliver adenosine to the bone tissue and mitigate osteoporotic-mediated bone loss through the promotion of osteoblastogenesis and inhibition of osteoclastogenesis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aeabcff7980d168299b134d0b2829ab5
https://pubmed.ncbi.nlm.nih.gov/35929516
https://pubmed.ncbi.nlm.nih.gov/35929516
Autor:
Yu-Ru V. Shih, David Kingsley, Hunter Newman, Jiaul Hoque, Ankita Gupta, B. Duncan X. Lascelles, Shyni Varghese
Skeletal injuries are a major cause of morbidities worldwide with bone fractures accounting for a substantial portion. Patients suffering from bone fractures and undergoing surgery experience different levels of pain throughout the healing process re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99097a66c14a291a2516a479ffb11ee0
https://doi.org/10.1101/2022.05.27.493755
https://doi.org/10.1101/2022.05.27.493755
Publikováno v:
Biomaterials
Impaired bone healing occurs in 5-10% of cases following injury, leading to a significant economic and clinical impact. While an inflammatory response upon injury is necessary to facilitate healing, its resolution is critical for bone tissue repair a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f054e1d329a81484e7b2e2a3f636c99
https://europepmc.org/articles/PMC8545578/
https://europepmc.org/articles/PMC8545578/
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 3 (2015)
Human embryonic stem cells (hESCs) are attractive cell sources for tissue engineering and regenerative medicine due to their self-renewal and differentiation ability. Design of biomaterials with an intrinsic ability that promotes hESC differentiation
Externí odkaz:
https://doaj.org/article/a92f35a2f4db46fcb4f4be615e3e8b04
Autor:
Yu Ru V. Shih, Shyni Varghese
Publikováno v:
Biomaterials. 198:107-121
Recent advances in materials development and tissue engineering has resulted in a substantial number of bioinspired materials that recapitulate cardinal features of bone extracellular matrix (ECM) such as dynamic inorganic and organic environment(s),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6c6dd8fd51bebb9d6746f296262b4af
https://doi.org/10.1016/j.biomaterials.2018.06.005
https://doi.org/10.1016/j.biomaterials.2018.06.005
Autor:
Genghao Chen, Prashant Mali, Ashwin Ganesh, Yu Ru V. Shih, Dario Meluzzi, Atharv Worlikar, Shyni Varghese, Dhruva Katrekar
Publikováno v:
Nature methods, vol 16, iss 3
Nature methods
Nature methods
We present in vivo sequence-specific RNA base editing via adenosine deaminases acting on RNA (ADAR) enzymes with associated ADAR guide RNAs (adRNAs). To achieve this, we systematically engineered adRNAs to harness ADARs, and comprehensively evaluated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c095da4f8ec9773531f525df8d6ecefd
https://doi.org/10.1038/s41592-019-0323-0
https://doi.org/10.1038/s41592-019-0323-0
Publikováno v:
Transplantation. 102:e373-e381
Given the shortage of available organs for whole or partial liver transplantation, hepatocyte cell transplantation has long been considered a potential strategy to treat patients suffering from various liver diseases. Some of the earliest approaches
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4645daba441ab386e657c228e1e6b4c
https://doi.org/10.1097/tp.0000000000002330
https://doi.org/10.1097/tp.0000000000002330
Autor:
Yu Ru V. Shih, John Naughton, Xin Fu, Jie Zhu, Prashant Mali, Jasmine Tat, Ana M. Moreno, Jessica Cabotaje, Kang Zhang, Leszek Lisowski, John M. Marlett, Shyni Varghese, Dhruva Katrekar
Publikováno v:
Mol Ther
Molecular therapy : the journal of the American Society of Gene Therapy, vol 26, iss 7
Molecular therapy : the journal of the American Society of Gene Therapy, vol 26, iss 7
Development of efficacious invivo delivery platforms for CRISPR-Cas9-based epigenome engineering will be critical to enable the ability to target human diseases without permanent modification of the genome. Toward this, we utilized split-Cas9 systems
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::278ec8ade060cd3f577f78f6fd2a67cc
https://doi.org/10.1016/j.ymthe.2018.04.017
https://doi.org/10.1016/j.ymthe.2018.04.017
Autor:
Jiaul Hoque, Yu Ru V. Shih, Shyni Varghese, Ji Hyun Ryu, Sajeesh Kumar Madhurakkat Perikamana, Vardhman Kumar, Nailah M. Seale
Publikováno v:
Advanced Functional Materials. 32:2108221
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab50605f8270843e38ded01098881a4d
https://doi.org/10.1002/adfm.202108221
https://doi.org/10.1002/adfm.202108221