Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Yu M. Xia"'
Autor:
Huiyong Hu, Barry Patrick Hart, Roopa Rai, Michael J. Green, Ravi Rajagopalan, Yu M. Xia, Joseph D. Ho, John R. Somoza, Isabelle Lehoux, Dange Vijay Kumar, Jennifer Riggs, Ken A. Brameld, James W. Janc, Tony Ton, Wendy B. Young
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:300-304
The discovery and optimization of a novel class of quinolone small-molecules that inhibit NS5B polymerase, a key enzyme of the HCV viral life-cycle, is described. Our research led to the replacement of a hydrolytically labile ester functionality with
Autor:
Huiyong Hu, Tony Ton, Dange Vijay Kumar, Roopa Rai, Michael J. Green, Isabelle Lehoux, Ravi Rajagopalan, Ken A. Brameld, John R. Somoza, Michael B. Shaghafi, James W. Janc, Nhat To, Yu M. Xia, Wendy B. Young
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(1)
Hepatitis C virus (HCV) infection is treated with a combination of peginterferon alfa-2a/b and ribavirin. To address the limitations of this therapy, numerous small molecule agents are in development, which act by directly affecting key steps in the