Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Yu Keung Mok"'
Autor:
Quy T.N. Tran, Phyllis X.L. Gan, Wupeng Liao, Yu Keung Mok, Christina L.L. Chai, W.S. Fred Wong
Publikováno v:
Pharmacological Research, Vol 194, Iss , Pp 106861- (2023)
The p38MAPK-MK2 signaling axis functions as an initiator of inflammation. Targeting the p38MAPK-MK2 signaling axis represents a direct therapeutic intervention of inflammatory diseases. We described here a novel role of andrographolide (AG), a small-
Externí odkaz:
https://doaj.org/article/fc9e6c19302c4d7f9cff817171450cde
Autor:
Su Ning Loh, Ian Russell Anthony, Edem Gavor, Xin Shan Lim, R. Manjunatha Kini, Yu Keung Mok, J. Sivaraman
Publikováno v:
Biology, Vol 13, Iss 1, p 42 (2024)
Salivary proteins from mosquitoes have received significant attention lately due to their potential to develop therapeutic treatments or vaccines for mosquito-borne diseases. Here, we report the characterization of LTRIN (lymphotoxin beta receptor in
Externí odkaz:
https://doaj.org/article/e9b48eb185704940bbb4e0572f24009c
Autor:
Shih-Chia Yeh, Mayra Diosa-Toro, Wei-Lian Tan, Florian Rachenne, Arthur Hain, Celestia Pei Xuan Yeo, Inès Bribes, Benjamin Wong Wei Xiang, Gayathiri Sathiamoorthy Kannan, Menchie Casayuran Manuel, Dorothée Missé, Yu Keung Mok, Julien Pompon
Publikováno v:
PLoS Pathogens, Vol 18, Iss 9, p e1010427 (2022)
Dengue viruses (DENV) are expanding global pathogens that are transmitted through the bite of mosquitoes, mostly Aedes aegypti. As RNA viruses, DENV rely on RNA-binding proteins (RBPs) to complete their life cycle. Alternatively, RBPs can act as rest
Externí odkaz:
https://doaj.org/article/71d32380c5c44bd79549c030e3adbc3f
Autor:
Edem Gavor, Yeu Khai Choong, Yonghao Liu, Julien Pompon, Eng Eong Ooi, Yu Keung Mok, Haiyan Liu, R Manjunatha Kini, J Sivaraman
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 16, Iss 9, p e0010743 (2022)
Mosquito saliva proteins modulate the human immune and hemostatic systems and control mosquito-borne pathogenic infections. One mechanism through which mosquito proteins may influence host immunity and hemostasis is their interactions with key human
Externí odkaz:
https://doaj.org/article/95f02715ee0e49d99342b9a0e1dd98e1
Autor:
Karthik Ramesh, Varsha A. Walvekar, Benjamin Wong, Ahmed Mahmoud Mohammed Sayed, Dorothée Missé, R. Manjunatha Kini, Yu Keung Mok, Julien Pompon
Publikováno v:
iScience, Vol 21, Iss , Pp 564-576 (2019)
Summary: Dengue symptoms include alteration of blood coagulation and fibrinolysis, causing severe hemorrhage and death. Here, we demonstrate that higher concentration of plasmin, the human fibrinolytic factor, in blood meal enhances dengue virus (DEN
Externí odkaz:
https://doaj.org/article/8d4ebf93ffe2462b85815c9f30a9f705
Autor:
Kang Wei Tan, Chacko Jobichen, Tan Ching Ong, Yun Feng Gao, Yuen Sung Tiong, Kang Ning Wong, Fook Tim Chew, J Sivaraman, Yu Keung Mok
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e44850 (2012)
Der f 7 is the group 7 allergen from the dust mite Dermatophagoides farinae, homologous to the major allergen Der p 7 from D. pteronyssinus. Monoclonal antibody that bind to residues Leu48 and Phe50 was found to inhibit IgE binding to residue Asp159,
Externí odkaz:
https://doaj.org/article/907dfe8663ef4dc19680013a60988b20
Publikováno v:
Protein Sci
Metallocarboxypeptidases (MCPs) in the mosquito midgut play crucial roles in infection, as well as in mosquito dietary digestion, reproduction, and development. MCPs are also part of the digestive system of plant-feeding insects, representing key tar
Publikováno v:
Cellular and Molecular Life Sciences. 79
Tripartite motif (TRIM) E3 ligases target specific substrates, including viral proteins, for proteasomal degradation, and are thus essential regulators of the innate antiviral response. TRIM69 ubiquitinates the non-structural NS3 protein of Dengue vi
Autor:
Varsha Ashok Walvekar, Karthik Ramesh, Muthu Kannan, R. Manjunatha Kini, J. Sivaraman, Yu Keung Mok
Publikováno v:
Bioscience reports. 42(5)
Kazal-type protease inhibitors strictly regulate Factor XIIa (FXIIa), a blood-clotting serine protease. However, when negatively charged surface of prosthetic device come into contact with FXII, it undergoes conformational change and auto-activation,
Publikováno v:
International Journal of Biological Macromolecules. 148:89-101
Redox signaling and homeostasis are essential for cell survival and the immune response. Peroxiredoxin (Prx) modulates the level of H2O2 as a redox signal through H2O2 decomposition. The redox activity of thioredoxin (Trx) is required as a reducing e