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Akademický článek

Epigenetic-genetic chromosome dosage approach for fetal trisomy 21 detection using an autosomal genetic reference marker.

Autor: Yu K Tong, Rossa W K Chiu, Ranjit Akolekar, Tak Y Leung, Tze K Lau, Kypros H Nicolaides, Y M Dennis Lo

Publikováno v: PLoS ONE, Vol 5, Iss 12, p e15244 (2010)

BACKGROUND: The putative promoter of the holocarboxylase synthetase (HLCS) gene on chromosome 21 is hypermethylated in placental tissues and could be detected as a fetal-specific DNA marker in maternal plasma. Detection of fetal trisomy 21 (T21) has

Externí odkaz: https://doaj.org/article/f19c720cb318488a803636a4e4e16669

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Sequencing-based counting and size profiling of plasma Epstein-Barr virus DNA enhance population screening of nasopharyngeal carcinoma

Autor: Peiyong Jiang, Yu K. Tong, Wanxia Gai, Anthony T.C. Chan, Edwin P. Hui, W K Jacky Lam, Brigette B.Y. Ma, Wenlei Peng, Rossa W.K. Chiu, Y.M. Dennis Lo, John K. S. Woo, O Y Olivia Tse, S. H. Cheng, Benny Zee, K.C. Allen Chan, Haiqiang Zhang

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America

Significance We identified differentiating molecular characteristics of plasma EBV DNA between nasopharyngeal carcinoma (NPC) patients and non-NPC subjects. Sequencing-based analysis revealed higher amounts of plasma EBV DNA and generally longer frag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28833dea5ca372cfef51754186562e41
https://pubmed.ncbi.nlm.nih.gov/29760067

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Second generation noninvasive fetal genome analysis reveals de novo mutations, single-base parental inheritance, and preferred DNA ends

Autor: Yuk Ming Dennis Lo, Irena Hudecova, Rossa W.K. Chiu, K.C. Allen Chan, Peiyong Jiang, Yu K. Tong, Tak Yeung Leung, Ada I. C. Wong, Kun Sun, Yvonne Kwun Yue Cheng, Suk Hang Cheng

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 113(50)

Plasma DNA obtained from a pregnant woman was sequenced to a depth of 270× haploid genome coverage. Comparing the maternal plasma DNA sequencing data with the parental genomic DNA data and using a series of bioinformatics filters, fetal de novo muta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb4683c0973e63379fc086dfe56c0a61
https://pubmed.ncbi.nlm.nih.gov/27911833

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Universal Haplotype-Based Noninvasive Prenatal Testing for Single Gene Diseases

Autor: Rossa W K Chiu, Y M Dennis Lo, Tak Y Leung, K C Allen Chan, Rezan A Kadir, Maria I New, Yvonne K Y Cheng, Wing-Shan Lee, Yu K Tong, Peiyong Jiang, Winnie W I Hui

Publikováno v: Clinical chemistry. 63(2)

BACKGROUND Researchers have developed approaches for the noninvasive prenatal testing of single gene diseases. One approach that allows for the noninvasive assessment of both maternally and paternally inherited mutations involves the analysis of sing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8cf31bfad1915d9fb24504841d1894c
https://pubmed.ncbi.nlm.nih.gov/27932412

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Proteomic analysis reveals platelet factor 4 and beta-thromboglobulin as prognostic markers in severe acute respiratory syndrome

Autor: Sai M. Ngai, Ronald T.K. Pang, Y.M. Dennis Lo, Rossa W.K. Chiu, Yu K. Tong, Terence C.W. Poon, K.C. Allen Chan, Stephen S.C. Chim, Joseph J.Y. Sung, Nelson Lee

Publikováno v: ELECTROPHORESIS. 33:1894-1900

Previously, we reported that proteomic fingerprints were present in sera of patients with severe acute respiratory syndrome (SARS), and could separate patients into subgroups with different prognoses. In the present study, we examined the prognostic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7cc46ac990023eedcc90ebcde91a436f
https://doi.org/10.1002/elps.201200002

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Systematic Search for Placental DNA-Methylation Markers on Chromosome 21: Toward a Maternal Plasma-Based Epigenetic Test for Fetal Trisomy 21

Autor: Lisa Y.S. Chan, Wing Shan Lee, Yu K. Tong, Tak Yeung Leung, Shengnan Jin, Chunming Ding, Ningning Yang, Y.M. Dennis Lo, Rossa W.K. Chiu, Yongjie Jin, Tze K. Lau, Tracy Yuen Han Lee, Fiona M.F. Lun, Stephen S.C. Chim

Publikováno v: Clinical Chemistry. 54:500-511

Background: The presence of fetal DNA in maternal plasma represents a source of fetal genetic material for noninvasive prenatal diagnosis; however, the coexisting background maternal DNA complicates the analysis of aneuploidy in such fetal DNA. Recen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29048e18464c5e118de58ae952d1cea4
https://doi.org/10.1373/clinchem.2007.098731

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Plasma DNA tissue mapping by genome-wide methylation sequencing for noninvasive prenatal, cancer, and transplantation assessments

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 112(40)

Plasma consists of DNA released from multiple tissues within the body. Using genome-wide bisulfite sequencing of plasma DNA and deconvolution of the sequencing data with reference to methylation profiles of different tissues, we developed a general a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a794fcb779ed228b9bf8303814aceb2
https://pubmed.ncbi.nlm.nih.gov/26392541

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ACE2 Gene Polymorphisms Do Not Affect Outcome of Severe Acute Respiratory Syndrome

Autor: Louis Yik-Si Chan, K.C. Allen Chan, David S.C. Hui, Grace Tin-Yun Chung, Wing Shan Lee, Y.M. Dennis Lo, Yu K. Tong, Paul K.S. Chan, Nelson L.S. Tang, Ying Man Sung, Rossa W.K. Chiu, Stephen S.C. Chim

Publikováno v: Clinical Chemistry

Severe acute respiratory syndrome (SARS) is the first pandemic of the 21st century (1). Since its recognition, 8437 individuals have been affected and 813 have died (2). Approximately 20–30% of patients required intensive care admission (1). Althou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::399ca1ddcf3990edfa908781e502d959
https://doi.org/10.1373/clinchem.2004.035436

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Serial Analysis of Plasma Proteomic Signatures in Pediatric Patients with Severe Acute Respiratory Syndrome and Correlation with Viral Load

Autor: Ellis K.L. Hon, Yu K. Tong, Albert M. Li, Pak Cheung Ng, Terence C.W. Poon, Rossa W.K. Chiu, K.C. Allen Chan, Irene L. Ang, Tai Fai Fok, Y.M. Dennis Lo, Enders K.O. Ng, Frankie W.T. Cheng

Publikováno v: Clinical Chemistry

An outbreak of severe acute respiratory syndrome (SARS) has affected 33 countries on five continents, with 8098 suspected and probable cases and 774 deaths. During the SARS epidemic, more than 1700 infected cases have been reported in Hong Kong. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::048a8ef19503221373ea4e1e53f1dccc
https://doi.org/10.1373/clinchem.2004.035352

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Systematic micro-array based identification of placental mRNA in maternal plasma: towards non-invasive prenatal gene expression profiling

Autor: Tze K. Lau, Y M D Lo, Enders K.O. Ng, Tse N. Leung, Nancy B.Y. Tsui, Stephen S.C. Chim, Rossa W.K. Chiu, Kwan Chee Chan, Yu K. Tong

Publikováno v: Scopus-Elsevier

The discovery of fetal DNA in the plasma of pregnant women1 has led to the development of promising approaches for non-invasive prenatal diagnosis.2–6 However, as fetal and maternal DNA species co-exist in maternal plasma, these DNA based diagnosti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5486098aa634911056bd715ee59b58b2
https://doi.org/10.1136/jmg.2003.016881

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