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Development of a three-dimensional growth prediction model for the Japanese scallop in Funka Bay, Japan, using OGCM and MODIS

Autor: Yu Ihara, Yang Liu, Yoichi Ishikawa, Makoto Kanamori, Xun Zhang, Satoshi Nakada, Sei-Ichi Saitoh, Katsuhisa Baba, Toru Hirawake

Publikováno v: ICES Journal of Marine Science. 72:2684-2699

The Japanese scallop (Patinopecten (Mizuhopecten) yessoensis) is an important commercial species in Funka Bay, Japan, where it is farmed using the hanging culture method. Our study was based on 6 years (from 2006 to 2011) of monthly in situ observati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b2fc91f3605e7f611685b509c8bd665e
https://doi.org/10.1093/icesjms/fsv153

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Inhibition of gastric inhibitory polypeptide signaling prevents obesity

Publikováno v: Nature Medicine. 8:738-742

Secretion of gastric inhibitory polypeptide (GIP), a duodenal hormone, is primarily induced by absorption of ingested fat. Here we describe a novel pathway of obesity promotion via GIP. Wild-type mice fed a high-fat diet exhibited both hypersecretion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a25f5341a5e1f52f18d1bbece3f3914a
https://doi.org/10.1038/nm727

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Genomic variation in pancreatic ion channel genes in Japanese type 2 diabetic patients

Autor: Yuichiro Yamada, Yoshiyuki Tsuura, Akira Kubota, Akira Kuroe, Qing Li, Yutaka Seino, Yu Ihara, Yoshimichi Someya

Publikováno v: Diabetes/Metabolism Research and Reviews. 17:213-216

Background Many genetic diseases are caused by mutations in ion channel genes. Because type 2 diabetes is characterized by pancreatic β-cell insensitivity to glucose, the genes responsible for glucose metabolism and calcium signaling in pancreatic �

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa456c7908d820e6689606266a093aaf
https://doi.org/10.1002/dmrr.193

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Sustained Enhancement of Ca2+ Influx by Glibenclamide Induces Apoptosis in RINm5F Cells

Autor: Yutaka Seino, Akari Inada, Shimpei Fujimoto, Yuichiro Yamada, Shinji Kagimoto, Toshio Iwakura, Akira Kubota, Yu Ihara, Yoshimichi Someya

Publikováno v: Biochemical and Biophysical Research Communications. 271:422-428

Cytosolic Ca(2+) elevations are known to be involved in triggering apoptosis in many tissues, but the effect of sustained enhancement of Ca(2+) influx on apoptosis in beta cells remains unknown. We have found that the viability of RINm5F cells is dec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cee719b6dd2f64fed678e81da452f6d7
https://doi.org/10.1006/bbrc.2000.2616

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Glucose intolerance caused by a defect in the entero-insular axis: A study in gastric inhibitory polypeptide receptor knockout mice

Autor: Mariko Kajikawa, Jun-ichi Miyazaki, Akira Kubota, Takahito Jomori, Nobuhiro Ban, Hitoshi Niwa, Yuichiro Yamada, Tokuyuki Yamashita, Fumi Tashiro, Yutaka Seino, Kinsuke Tsuda, Akira Kuroe, Yu Ihara, Kazumasa Miyawaki, S. Fujimoto, Hiroyuki Hashimoto, Hideki Yano

Publikováno v: Proceedings of the National Academy of Sciences. 96:14843-14847

Mice with a targeted mutation of the gastric inhibitory polypeptide (GIP) receptor gene ( GIPR ) were generated to determine the role of GIP as a mediator of signals from the gut to pancreatic β cells. GIPR −/− mice have higher blood glucose lev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c2a6b2b7d21eec9ee29b64d34175990
https://doi.org/10.1073/pnas.96.26.14843

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The Cyclic AMP Response Element Modulator Family Regulates the Insulin Gene Transcription by Interacting with Transcription Factor IID

Autor: Akira Kubota, Yuichiro Yamada, Nobuhiro Ban, Akari Inada, Rie Watanabe, Yutaka Seino, Yoshimichi Someya, Kinsuke Tsuda, Yu Ihara

Publikováno v: Journal of Biological Chemistry. 274:21095-21103

We analyzed a mechanism of transcriptional regulation of the human insulin gene by cyclic AMP response element modulator (CREM) through four cyclic AMP response elements (CREs). We isolated two novel CREM isoforms (CREMDeltaQ1 and CREMDeltaQ2), which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab047edf8ad2e0188af4f7d1d13aa200
https://doi.org/10.1074/jbc.274.30.21095

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The MH1 Domains of Smad2 and Smad3 Are Involved in the Regulation of the ALK7 Signals

Autor: Yuichiro Yamada, Tetsuya Adachi, Yutaka Seino, Rie Watanabe, Yasuhiro Sunaga, Toshio Iwakura, Nobuhiro Ban, Yoshimichi Someya, Akira Kuroe, Yu Ihara, Zhen-Ping Shen, Akira Kubota, Shinji Kagimoto, Kinsuke Tsuda, Kazumasa Miyawaki, Akari Inada

Publikováno v: Biochemical and Biophysical Research Communications. 254:707-712

The biological responses of the transforming growth factor beta (TGF-beta) superfamily are induced by activation of a receptor complex and Smad proteins. We surveyed the TGF-beta superfamily receptors using the degenerate PCR strategy, and found acti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::455a5fe794cac082da7ffcf3614a7b15
https://doi.org/10.1006/bbrc.1998.0118

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Identification of two missense mutations in the GIP receptor gene: a functional study and association analysis with NIDDM: no evidence of association with Japanese NIDDM subjects

Autor: Tomohiko Taminato, Akira Kubota, Yuichiro Yamada, Kinsuke Tsuda, Yutaka Seino, Koichiro Yasuda, Shinji Kagimoto, Tadao Hayami, Yoshimichi Someya, Rie Watanabe, Yu Ihara

Publikováno v: Diabetes. 45:1701-1705

Gastric inhibitory polypeptide (GIP) potently stimulates insulin secretion from pancreatic islets in the presence of glucose as an incretin. Because the insulinotropic effect of GIP is reduced in NIDDM, it should be clarified whether defects in the G

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::724d0830c38ffd4dbf94683434d86949
https://doi.org/10.2337/diabetes.45.12.1701

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