Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Yu Ichi Tsukada"'
Autor:
Akio Kawabe, Kaoru Yamagata, Shigeaki Kato, Kazuhisa Nakano, Kei Sakata, Yu-ichi Tsukada, Koichiro Ohmura, Shingo Nakayamada, Yoshiya Tanaka
Publikováno v:
Arthritis Research & Therapy, Vol 24, Iss 1, Pp 1-10 (2022)
Abstract Background Rheumatoid arthritis (RA) patients present with abnormal methylation patterns in their fibroblast-like synoviocytes (FLS). Given that DNA demethylation is critical for producing DNA methylation patterns, we hypothesized that DNA d
Externí odkaz:
https://doaj.org/article/172171df36094667a2692a01faafe430
Autor:
Marino Maemura, Hiroaki Taketsuru, Yuki Nakajima, Ruiqi Shao, Ayaka Kakihara, Jumpei Nogami, Yasuyuki Ohkawa, Yu-ichi Tsukada
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-20 (2021)
Abstract In multicellular organisms, oocytes and sperm undergo fusion during fertilization and the resulting zygote gives rise to a new individual. The ability of zygotes to produce a fully formed individual from a single cell when placed in a suppor
Externí odkaz:
https://doaj.org/article/32d8f9ca35ce40d48451b0c8ff8c54cf
Publikováno v:
Biochemical and Biophysical Research Communications. 591:50-53
Cryopreservation of embryos is a useful method for stably preserving various strains for a long time, and the cryopreserved embryos can be used at any time by simple warming. However, the viability of cryopreserved embryos, particularly vitrification
Autor:
Soichiro Yamanaka, Yohko Kitagawa, Hiroko Nakatsukasa, Jinghua Yin, Mayumi Oda, Shimon Sakaguchi, Mana Koga-Iizuka, Yu Ichi Tsukada, Akihiko Yoshimura, Qianjin Lu, Naganari Ohkura, Jun Kohyama, Minako Ito, Ikuko Koya, Takeji Takamura-Enya, Shunsuke Chikuma, Tsukasa Sanosaka, Kazue Someya
Publikováno v:
International Immunology. 31:335-347
Ten-eleven translocation (TET) proteins regulate DNA methylation and gene expression by converting 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). Although Tet2/Tet3 deficiency has been reported to lead to myeloid cell, B-cell and invariant
Autor:
Taisuke Kondo, Takashi Akanuma, Minako Ito, Jun Kohyama, Akihiko Yoshimura, Kazue Someya, Tsukasa Sanosaka, Yu Ichi Tsukada, Ikuko Koya, Kenn ichi Tateda, Takeji Takamura-Enya, Hiroko Nakatsukasa
Publikováno v:
International Immunology
Retroviral TET1 or hypoxia stabilize Foxp3 in iTregs generated in vitro
Since induced regulatory T cells (iTregs) can be produced in a large quantity in vitro, these cells are expected to be clinically useful to induce immunological tolerance in
Since induced regulatory T cells (iTregs) can be produced in a large quantity in vitro, these cells are expected to be clinically useful to induce immunological tolerance in
Autor:
Atsushi Kaneda, Yu-ichi Tsukada
This book will focus on DNA and histone methylation in epigenetics and describe how it is involved in the molecular mechanisms responsible for the development of cancer. Chapters will summarize the current knowledge of the molecular basis of DNA and
Publikováno v:
Genes & Development. 24:432-437
Methylation of histone H3 Lys 9 and Lys 27 (H3K9 and H3K27) is associated with transcriptional silencing. Here we show that KDM7, a JmjC domain-containing protein, catalyzes demethylation of both mono- or dimethylated H3K9 and H3K27. Inhibition of KD
Publikováno v:
Nature Structural & Molecular Biology. 15:1169-1175
The Ink4a-Arf-Ink4b locus has a crucial role in both cellular senescence and tumorigenesis. JmjC domain-containing histone demethylase 1b (Jhdm1b, also known as Kdm2b and Fbxl10), the mammalian paralog of the histone demethylase Jhdm1a (also known as
Publikováno v:
J.Cell.Biochem.. 104:176-188
Strong activation of the ERK signal is required for hepatocyte growth factor (HGF) to inhibit proliferation of the human hepatocellular carcinoma cell line HepG2. However, it is still to be elucidated whether the activation alone is sufficient to ind
Publikováno v:
Scientific Reports
The development of multicellular organisms is accompanied by reprogramming of the epigenome in specific cells, with the epigenome of most cell types becoming fixed after differentiation. Genome-wide reprogramming of DNA methylation occurs in primordi