Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Yu Hisano"'
Autor:
Karen Mendelson, Suveg Pandey, Yu Hisano, Frank Carellini, Bhaskar C Das, Timothy Hla, Todd Evans
Publikováno v:
eLife, Vol 6 (2017)
Sphingosine-1-phosphate (S1P) is generated through phosphorylation of sphingosine by sphingosine kinases (Sphk1 and Sphk2). We show that sphk2 maternal-zygotic mutant zebrafish embryos (sphk2MZ) display early developmental phenotypes, including a del
Externí odkaz:
https://doaj.org/article/ad842b585d4f43c18c5d212ab4468be7
Publikováno v:
Biology Open, Vol 2, Iss 8, Pp 789-794 (2013)
Summary The lipid mediator sphingosine-1-phosphate (S1P) is a regulator of cardiac development in zebrafish, as disruption of its receptor s1pr2 or transporter spns2 causes migration defects in cardiac progenitors. To examine the genetic interaction
Externí odkaz:
https://doaj.org/article/683dbe1a25c84333b82094d3b2c0fd27
Autor:
Yu Hisano, Satoshi Ota, Kazuharu Arakawa, Michiko Muraki, Nobuaki Kono, Kazuki Oshita, Tetsushi Sakuma, Masaru Tomita, Takashi Yamamoto, Yasushi Okada, Atsuo Kawahara
Publikováno v:
Biology Open, Vol 2, Iss 4, Pp 363-367 (2013)
Summary Artificially designed nucleases such as zinc-finger nucleases (ZFNs) and transcription activator-like effector nucleases (TALENs) can induce a targeted DNA double-strand break at the specific target genomic locus, leading to the frameshift-me
Externí odkaz:
https://doaj.org/article/9b7f12afc71e402790efcd9b536b7ebd
Autor:
Kawahara, Atsuo1 akawahara@yamanashi.ac.jp, Yu Hisano2 y.hisano@riken.jp, Satoshi Ota1 satoshio-as@yamanashi.ac.jp, Kiyohito Taimatsu1 ktaimatsu@yamanashi.ac.jp
Publikováno v:
International Journal of Molecular Sciences. May2016, Vol. 17 Issue 5, p727. 10p. 4 Diagrams.
Autor:
Koki Kawakami, Junken Aoki, Andreane Cartier, Andrew Kuo, Wenji Piao, Yanbao Xiong, Keisuke Yanagida, Satoru Ishida, Timothy Hla, Jonathan S. Bromberg, Sylvain Galvani, Yu Hisano, Mari Kono, Asuka Inoue, Richard L. Proia, Yuki Ono, Kuniyuki Kano, Eric Engelbrecht
Publikováno v:
The Journal of Experimental Medicine
Sphingosine 1-phosphate receptor-1 signaling via the Gi pathway is suppressed by lysophosphatidic acid receptor-1, which recruits β-arrestin to the heterotypic receptor complex. This mechanism occurs at sinus lining lymphatic endothelial cells of ly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9806caec5142cf2ec3b61439e550e490
https://doi.org/10.1084/jem.20181895
https://doi.org/10.1084/jem.20181895
Autor:
Yu Hisano, Timothy Hla
Publikováno v:
Pharmacology & Therapeutics. 193:91-98
While normal angiogenesis is critical for development and tissue growth, pathological angiogenesis is important for the growth and spread of cancers by supplying nutrients and oxygen as well as providing a conduit for distant metastasis. The interact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baf1eb2b84a7e1842ec28976ef913964
https://doi.org/10.1016/j.pharmthera.2018.07.006
https://doi.org/10.1016/j.pharmthera.2018.07.006
Publikováno v:
International Journal of Molecular Sciences, Vol 17, Iss 5, p 727 (2016)
The zebrafish (Danio rerio) is an ideal vertebrate model to investigate the developmental molecular mechanism of organogenesis and regeneration. Recent innovation in genome editing technologies, such as zinc finger nucleases (ZFNs), transcription act
Externí odkaz:
https://doaj.org/article/1ae40f84f24847b4b3f86d6a074037b1
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e38941 (2012)
Sphingosine-1-phosphate (S1P), a sphingolipid metabolite that is produced inside the cells, regulates a variety of physiological and pathological responses via S1P receptors (S1P1-5). Signal transduction between cells consists of three steps; the syn
Externí odkaz:
https://doaj.org/article/fe4c22080eab4544ac033ebafff191d7
Autor:
Koki Kawakami, Junken Aoki, Andrew Kuo, Eric Engelbrecht, Keisuke Yanagida, Satoru Ishida, Andreane Cartier, Yuki Ono, Timothy Hla, Mari Kono, Asuka Inoue, Richard L. Proia, Sylvain Galvani, Yu Hisano
Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) activate G protein-coupled receptors (GPCRs) to regulate key pathobiological processes. Here we report a novel lipid mediator GPCR cross-talk mechanism that modulates lymphatic endothelial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b43c71144a8d9c83e6cb72dc7dacf6d
Autor:
Yu Hisano, Naoki Kobayashi, Shoko Kawasaki-Nishi, Akihito Yamaguchi, Tsuyoshi Nishi, Masato Otsuka
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Scientific Reports
Scientific Reports
Sphingosine 1-phosphate (S1P) is an intercellular signaling molecule present in blood. Erythrocytes have a central role in maintaining the S1P concentration in the blood stream. We previously demonstrated that S1P is exported from erythrocytes by a g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75f0bda6998371de63c643eff602d36f
https://doi.org/10.1038/s41598-018-23300-x
https://doi.org/10.1038/s41598-018-23300-x