Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Yu Hayashi"'
Autor:
Yu Hayashi, Hiroki Okumura, Yuko Arioka, Itaru Kushima, Daisuke Mori, Tzuyao Lo, Gantsooj Otgonbayar, Hidekazu Kato, Yoshihiro Nawa, Hiroki Kimura, Branko Aleksic, Norio Ozaki
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Recent genetic studies have found common genomic risk variants among psychiatric disorders, strongly suggesting the overlaps in their molecular and cellular mechanism. Our research group identified the variant in ASTN2 as one of the candidat
Externí odkaz:
https://doaj.org/article/3af07917595949889e6dda16c01e5a06
Autor:
Daisuke Mori, Ryosuke Ikeda, Masahito Sawahata, Sho Yamaguchi, Akiko Kodama, Takashi Hirao, Yuko Arioka, Hiroki Okumura, Chihiro Inami, Toshiaki Suzuki, Yu Hayashi, Hidekazu Kato, Yoshihiro Nawa, Seiko Miyata, Hiroki Kimura, Itaru Kushima, Branko Aleksic, Hiroyuki Mizoguchi, Taku Nagai, Takanobu Nakazawa, Ryota Hashimoto, Kozo Kaibuchi, Kazuhiko Kume, Kiyofumi Yamada, Norio Ozaki
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Whole genome analysis has identified rare copy number variations (CNV) that are strongly involved in the pathogenesis of psychiatric disorders, and 3q29 deletion has been found to have the largest effect size. The 3q29 deletion mice model (3
Externí odkaz:
https://doaj.org/article/726eaa89594347c1a0578733db974080
Autor:
Ayaka Nakai, Mitsuaki Kashiwagi, Tomoyuki Fujiyama, Kanako Iwasaki, Arisa Hirano, Hiromasa Funato, Masashi Yanagisawa, Takeshi Sakurai, Yu Hayashi
Publikováno v:
Molecular Brain, Vol 17, Iss 1, Pp 1-9 (2024)
Abstract The AP-2 transcription factors are crucial for regulating sleep in both vertebrate and invertebrate animals. In mice, loss of function of the transcription factor AP-2β (TFAP2B) reduces non-rapid eye movement (NREM) sleep. When and where TF
Externí odkaz:
https://doaj.org/article/15e816988fa64c9093a05a4e7b4ce5c6
Autor:
Hiroki Kimura, Masahiro Nakatochi, Branko Aleksic, James Guevara, Miho Toyama, Yu Hayashi, Hidekazu Kato, Itaru Kushima, Mako Morikawa, Kanako Ishizuka, Takashi Okada, Yoshinori Tsurusaki, Atsushi Fujita, Noriko Miyake, Tomoo Ogi, Atsushi Takata, Naomichi Matsumoto, Joseph Buxbaum, Norio Ozaki, Jonathan Sebat
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Autism spectrum disorder (ASD) is a highly heritable, complex disorder in which rare variants contribute significantly to disease risk. Although many genes have been associated with ASD, there have been few genetic studies of ASD in the Japa
Externí odkaz:
https://doaj.org/article/35ba0a0e414d4e32a1a5db53151ae617
Autor:
Taizo Kawano, Mitsuaki Kashiwagi, Mika Kanuka, Chung-Kuan Chen, Shinnosuke Yasugaki, Sena Hatori, Shinichi Miyazaki, Kaeko Tanaka, Hidetoshi Fujita, Toshiro Nakajima, Masashi Yanagisawa, Yoshimi Nakagawa, Yu Hayashi
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112267- (2023)
Summary: Sleep is regulated by peripheral tissues under fatigue. The molecular pathways in peripheral cells that trigger systemic sleep-related signals, however, are unclear. Here, a forward genetic screen in C. elegans identifies 3 genes that strong
Externí odkaz:
https://doaj.org/article/97bf92a024cc488094eff41a043f31c1
Autor:
Mitsuaki Kashiwagi, Mika Kanuka, Kaeko Tanaka, Masayo Fujita, Ayaka Nakai, Chika Tatsuzawa, Kazuto Kobayashi, Kazutaka Ikeda, Yu Hayashi
Publikováno v:
Molecular Brain, Vol 14, Iss 1, Pp 1-4 (2021)
Abstract Despite the established roles of the dopaminergic system in promoting arousal, the effects of loss of dopamine on the patterns of sleep and wakefulness remain elusive. Here, we examined the sleep architecture of dopamine-deficient (DD) mice,
Externí odkaz:
https://doaj.org/article/f185785df9594fc2a899c8013e7919f3
Publikováno v:
iScience, Vol 25, Iss 6, Pp 104452- (2022)
Summary: The mechanisms underlying sleep homeostasis are poorly understood. The nematode Caenorhabditis elegans exhibits 2 types of sleep: lethargus, or developmentally timed, and stress-induced sleep. Lethargus is characterized by alternating cycles
Externí odkaz:
https://doaj.org/article/25e320bb126f4d4994fe114482d222d7
Autor:
Shinya Okuda, Takeo Nakayama, Norihito Uemura, Rie Hikawa, Masashi Ikuno, Hodaka Yamakado, Haruhisa Inoue, Naoko Tachibana, Yu Hayashi, Ryosuke Takahashi, Naohiro Egawa
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 21, p 13390 (2022)
Accumulation of α-synuclein (α-syn) is the pathological hallmark of α-synucleinopathy. Rapid eye movement (REM) sleep behavior disorder (RBD) is a pivotal manifestation of α-synucleinopathy including Parkinson’s disease (PD). RBD is clinically
Externí odkaz:
https://doaj.org/article/8bc4cc20acbe41399ee0c7d210c9dd64
Autor:
Risa Yamazaki, Hirofumi Toda, Paul-Antoine Libourel, Yu Hayashi, Kaspar E. Vogt, Takeshi Sakurai
Publikováno v:
Frontiers in Psychology, Vol 11 (2020)
Sleep is mandatory in most animals that have the nervous system and is universally observed in model organisms ranging from the nematodes, zebrafish, to mammals. However, it is unclear whether different sleep states fulfill common functions and are d
Externí odkaz:
https://doaj.org/article/ed31a34c270e4f6ba9d47bdbe9723027
Autor:
Douyan Wang, Yu Hayashi, Takahiro Enoki, Kenta Nakahara, Tetsuya Arita, Yuya Higashi, Yasuharu Kuno, Tatsuya Terazawa, Takao Namihira
Publikováno v:
Agronomy, Vol 12, Iss 1, p 173 (2022)
Recent years have seen numerous studies into how applying pulsed high electric fields (PEF) to living organisms induces various stress reactions. Plants produce glucose through photosynthesis and use this as a source of energy for living, yet there a
Externí odkaz:
https://doaj.org/article/4fe7e09e4fef4c88b7d3053f13616fb3