Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Yu Haranosono"'
Publikováno v:
Veterinary Medicine and Science, Vol 8, Iss 5, Pp 1946-1949 (2022)
Abstract Objective The present report characterises a spontaneous nictitating membrane abnormality in a Japanese white rabbit. Animal studied The animal was a male Japanese white rabbit (Oryctolagus cuniculus, Kbs:JW, 10 weeks old at the time of purc
Externí odkaz:
https://doaj.org/article/e5cfe5cffd8e4f19a39ea1bedfe00c4c
Publikováno v:
Genes and Environment, Vol 44, Iss 1, Pp 1-10 (2022)
Abstract Background In eye-drop drug development, the additional genotoxicity tests in some cases might be necessary to assess genotoxicity in the ocular surface since the ocular surface is exposed directly to high drug concentrations. Recently, an i
Externí odkaz:
https://doaj.org/article/625177d5f0b34d05bd6dcfcca2c8c431
Publikováno v:
Genes and Environment, Vol 43, Iss 1, Pp 1-8 (2021)
Abstract Background The in vivo comet assay is used to evaluate the genotoxic potential of compounds by detecting DNA strand breaks in cells isolated from animal tissue. The comet assay of hepatocytes is well established; however, the levels of syste
Externí odkaz:
https://doaj.org/article/76af64178d5746119ae6a9bcd3e4a0ee
Autor:
Kana Ikemoto, Shinya Kobayashi, Yu Haranosono, Seiko Kozai, Tomoyuki Wada, Hideki Tokushige, Akio Kawamura
Publikováno v:
BMC Ophthalmology, Vol 20, Iss 1, Pp 1-7 (2020)
Abstract Background We aimed to demonstrate the contribution of anti-inflammatory and anti-virulence effects of azithromycin (AZM) in ocular surface infection treatment. Methods Staphylococcus aureus was injected into the corneal stroma of rabbits to
Externí odkaz:
https://doaj.org/article/469fc99989dc41e49dd85087d91f3765
Autor:
Masayuki Mishima, Tsuneo Hashizume, Yu Haranosono, Yusuke Nagato, Kentaro Takeshita, Junichi Fukuchi, Masamitsu Homma
Publikováno v:
Genes and Environment, Vol 40, Iss 1, Pp 1-7 (2018)
Abstract Use of Quantitative Structure-Activity Relationships ((Q)SAR) prediction tools has been increasing since the International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use (ICH) M7 guideline was issued in
Externí odkaz:
https://doaj.org/article/009e70504f97401fab58461124520435
Publikováno v:
Journal of Toxicologic Pathology. 36:45-48
Autor:
Haruna Tahara, Yu Haranosono
Publikováno v:
Fundamental Toxicological Sciences. 10:105-112
Publikováno v:
Cutaneous and Ocular Toxicology. 40:26-36
An unscheduled DNA synthesis (UDS) test is used for in vitro or in vivo genotoxicity evaluation. The UDS test with hepatocytes is well established; however, drug exposure levels at the application ...
Autor:
Yu Haranosono, Yoshinori Yamagiwa, Haruna Tahara, Hiroshi Satoh, Kotaro Yamada, Miki Masatsugu, Masaaki Kurata
Publikováno v:
Journal of Toxicologic Pathology
Nickel subsulfide (Ni3S2) is known to induce intraocular neoplasms when injected intravitreally into the eyes of rats. Here, we found two extraocular orbital neoplasms in two different rat strains, presumably due to the leakage of locally injected Ni
Autor:
Yu Haranosono1 y-haranosono@senju.co.jp, Hiroki Ueoka1, Gakushi Kito1, Shingo Nemoto1, Masaaki Kurata1, Hideyuki Sakaki1
Publikováno v:
Journal of Toxicological Sciences. 2018, Vol. 43 Issue 3, p203-211. 9p.