Mitochondrial respiration is reduced in atherosclerosis, promoting necrotic core formation and reducing relative fibrous cap thickness

Autor: Bennett, MR, Yu, EPK, Reinhold, Starks, L, Uryga, Foote, Finigan, A, Figg, N, Pung, Y-F, Logan, A, Murphy, MP

Objective: Mitochondrial DNA (mtDNA) damage is present in murine and human atherosclerotic plaques. However, whether endogenous levels of mtDNA damage are sufficient to cause mitochondrial dysfunction, and whether decreasing mtDNA damage and improvin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93189bec7acd1839336dfbed29c2f5c4
https://www.repository.cam.ac.uk/handle/1810/274895

Mitochondrial Respiration Is Reduced in Atherosclerosis, Promoting Necrotic Core Formation and Reducing Relative Fibrous Cap Thickness.

Autor: Yu EPK; From the Division of Cardiovascular Medicine, Addenbrooke's Centre for Clinical Investigation, Addenbrooke's Hospital, University of Cambridge, United Kingdom (E.P.K.Y., J.R., H.Y., L.S., A.K.U., K.F., A.F., N.F., M.B.); Department of Biomedical Sciences, University of Nottingham, Malaysia Campus, Selangor, Malaysia (Y.-F.P.); and MRC Mitochondrial Biology Unit, Cambridge, United Kingdom (A.L., M.P.M.). epky2@cam.ac.uk mrb@mole.bio.cam.ac.uk., Reinhold J; From the Division of Cardiovascular Medicine, Addenbrooke's Centre for Clinical Investigation, Addenbrooke's Hospital, University of Cambridge, United Kingdom (E.P.K.Y., J.R., H.Y., L.S., A.K.U., K.F., A.F., N.F., M.B.); Department of Biomedical Sciences, University of Nottingham, Malaysia Campus, Selangor, Malaysia (Y.-F.P.); and MRC Mitochondrial Biology Unit, Cambridge, United Kingdom (A.L., M.P.M.)., Yu H; From the Division of Cardiovascular Medicine, Addenbrooke's Centre for Clinical Investigation, Addenbrooke's Hospital, University of Cambridge, United Kingdom (E.P.K.Y., J.R., H.Y., L.S., A.K.U., K.F., A.F., N.F., M.B.); Department of Biomedical Sciences, University of Nottingham, Malaysia Campus, Selangor, Malaysia (Y.-F.P.); and MRC Mitochondrial Biology Unit, Cambridge, United Kingdom (A.L., M.P.M.)., Starks L; From the Division of Cardiovascular Medicine, Addenbrooke's Centre for Clinical Investigation, Addenbrooke's Hospital, University of Cambridge, United Kingdom (E.P.K.Y., J.R., H.Y., L.S., A.K.U., K.F., A.F., N.F., M.B.); Department of Biomedical Sciences, University of Nottingham, Malaysia Campus, Selangor, Malaysia (Y.-F.P.); and MRC Mitochondrial Biology Unit, Cambridge, United Kingdom (A.L., M.P.M.)., Uryga AK; From the Division of Cardiovascular Medicine, Addenbrooke's Centre for Clinical Investigation, Addenbrooke's Hospital, University of Cambridge, United Kingdom (E.P.K.Y., J.R., H.Y., L.S., A.K.U., K.F., A.F., N.F., M.B.); Department of Biomedical Sciences, University of Nottingham, Malaysia Campus, Selangor, Malaysia (Y.-F.P.); and MRC Mitochondrial Biology Unit, Cambridge, United Kingdom (A.L., M.P.M.)., Foote K; From the Division of Cardiovascular Medicine, Addenbrooke's Centre for Clinical Investigation, Addenbrooke's Hospital, University of Cambridge, United Kingdom (E.P.K.Y., J.R., H.Y., L.S., A.K.U., K.F., A.F., N.F., M.B.); Department of Biomedical Sciences, University of Nottingham, Malaysia Campus, Selangor, Malaysia (Y.-F.P.); and MRC Mitochondrial Biology Unit, Cambridge, United Kingdom (A.L., M.P.M.)., Finigan A; From the Division of Cardiovascular Medicine, Addenbrooke's Centre for Clinical Investigation, Addenbrooke's Hospital, University of Cambridge, United Kingdom (E.P.K.Y., J.R., H.Y., L.S., A.K.U., K.F., A.F., N.F., M.B.); Department of Biomedical Sciences, University of Nottingham, Malaysia Campus, Selangor, Malaysia (Y.-F.P.); and MRC Mitochondrial Biology Unit, Cambridge, United Kingdom (A.L., M.P.M.)., Figg N; From the Division of Cardiovascular Medicine, Addenbrooke's Centre for Clinical Investigation, Addenbrooke's Hospital, University of Cambridge, United Kingdom (E.P.K.Y., J.R., H.Y., L.S., A.K.U., K.F., A.F., N.F., M.B.); Department of Biomedical Sciences, University of Nottingham, Malaysia Campus, Selangor, Malaysia (Y.-F.P.); and MRC Mitochondrial Biology Unit, Cambridge, United Kingdom (A.L., M.P.M.)., Pung YF; From the Division of Cardiovascular Medicine, Addenbrooke's Centre for Clinical Investigation, Addenbrooke's Hospital, University of Cambridge, United Kingdom (E.P.K.Y., J.R., H.Y., L.S., A.K.U., K.F., A.F., N.F., M.B.); Department of Biomedical Sciences, University of Nottingham, Malaysia Campus, Selangor, Malaysia (Y.-F.P.); and MRC Mitochondrial Biology Unit, Cambridge, United Kingdom (A.L., M.P.M.)., Logan A; From the Division of Cardiovascular Medicine, Addenbrooke's Centre for Clinical Investigation, Addenbrooke's Hospital, University of Cambridge, United Kingdom (E.P.K.Y., J.R., H.Y., L.S., A.K.U., K.F., A.F., N.F., M.B.); Department of Biomedical Sciences, University of Nottingham, Malaysia Campus, Selangor, Malaysia (Y.-F.P.); and MRC Mitochondrial Biology Unit, Cambridge, United Kingdom (A.L., M.P.M.)., Murphy MP; From the Division of Cardiovascular Medicine, Addenbrooke's Centre for Clinical Investigation, Addenbrooke's Hospital, University of Cambridge, United Kingdom (E.P.K.Y., J.R., H.Y., L.S., A.K.U., K.F., A.F., N.F., M.B.); Department of Biomedical Sciences, University of Nottingham, Malaysia Campus, Selangor, Malaysia (Y.-F.P.); and MRC Mitochondrial Biology Unit, Cambridge, United Kingdom (A.L., M.P.M.)., Bennett M; From the Division of Cardiovascular Medicine, Addenbrooke's Centre for Clinical Investigation, Addenbrooke's Hospital, University of Cambridge, United Kingdom (E.P.K.Y., J.R., H.Y., L.S., A.K.U., K.F., A.F., N.F., M.B.); Department of Biomedical Sciences, University of Nottingham, Malaysia Campus, Selangor, Malaysia (Y.-F.P.); and MRC Mitochondrial Biology Unit, Cambridge, United Kingdom (A.L., M.P.M.). epky2@cam.ac.uk mrb@mole.bio.cam.ac.uk.

Publikováno v: Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2017 Dec; Vol. 37 (12), pp. 2322-2332. Date of Electronic Publication: 2017 Sep 28.