Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Yu Chun Weng"'
Autor:
Lin-Yu Chen, Yu-Ting Chou, Phui-Ly Liew, Ling-Hui Chu, Kuo-Chang Wen, Shiou-Fu Lin, Yu-Chun Weng, Hui-Chen Wang, Po-Hsuan Su, Hung-Cheng Lai
Publikováno v:
Journal of Ovarian Research, Vol 17, Iss 1, Pp 1-12 (2024)
Abstract Background Ovarian cancer is the most lethal gynecological cancer. As the primary treatment, chemotherapy has a response rate of only 60–70% in advanced stages, and even lower as a second-line treatment. Despite guideline recommendations,
Externí odkaz:
https://doaj.org/article/ad9976421da742c6a2aa45c571630064
Autor:
Lin-Yu Chen, Yao-An Shen, Ling-Hui Chu, Po-Hsuan Su, Hui-Chen Wang, Yu-Chun Weng, Shiou-Fu Lin, Kuo-Chang Wen, Phui-Ly Liew, Hung-Cheng Lai
Publikováno v:
Antioxidants, Vol 13, Iss 6, p 735 (2024)
Ten-eleven translocation 1 (TET1) is a methylcytosine dioxygenase involved in active DNA demethylation. In our previous study, we demonstrated that TET1 reprogrammed the ovarian cancer epigenome, increased stem properties, and activated various regul
Externí odkaz:
https://doaj.org/article/b022b38c4efa4565a94f15f694fff7e3
NKX6-1 mediates cancer stem-like properties and regulates sonic hedgehog signaling in leiomyosarcoma
Autor:
Po-Hsuan Su, Rui-Lan Huang, Hung-Cheng Lai, Lin-Yu Chen, Yu-Chun Weng, Chih-Chien Wang, Chia-Chun Wu
Publikováno v:
Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-15 (2021)
Abstract Background Leiomyosarcoma (LMS), the most common soft tissue sarcoma, exhibits heterogeneous and complex genetic karyotypes with severe chromosomal instability and rearrangement and poor prognosis. Methods Clinical variables associated with
Externí odkaz:
https://doaj.org/article/6ad8d3cb550441c1afe6a070e5904090
Autor:
Quang Anh Do, Po-Hsuan Su, Chien-Wen Chen, Hui-Chen Wang, Yi-Xuan Lee, Yu-Chun Weng, Lin-Yu Chen, Yueh-Han Hsu, Hung-Cheng Lai
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 6, p 5598 (2023)
Window of implantation (WOI) genes have been comprehensively identified at the single cell level. DNA methylation changes in cervical secretions are associated with in vitro fertilization embryo transfer (IVF-ET) outcomes. Using a machine learning (M
Externí odkaz:
https://doaj.org/article/451a6300f45348c995f58cf520849750
Autor:
Yi-Xuan Lee, Po-Hsuan Su, Anh Q. Do, Chii-Ruei Tzeng, Yu-Ming Hu, Chi-Huang Chen, Chien-Wen Chen, Chi-Chun Liao, Lin-Yu Chen, Yu-Chun Weng, Hui-Chen Wang, Hung-Cheng Lai
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 2, p 1726 (2023)
The causes of implantation failure remain a black box in reproductive medicine. The exact mechanism behind the regulation of endometrial receptivity is still unknown. Epigenetic modifications influence gene expression patterns and may alter the recep
Externí odkaz:
https://doaj.org/article/7671907087ff4379bd4a7bfca1030615
Autor:
Darmawi, Lin-Yu Chen, Po-Hsuan Su, Phui-Ly Liew, Hui-Chen Wang, Yu-Chun Weng, Rui-Lan Huang, Hung-Cheng Lai
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 13, p 7158 (2022)
Endometrial cancer (EC) rates are rising annually. Additional prediction markers need to be evaluated because only 10–20% of EC cases show an objective response to immune-checkpoint inhibitors (ICIs). Our previous methylomic study found that BHLHE2
Externí odkaz:
https://doaj.org/article/3e6bec4f50714d9295c1034cf02f3b10
Autor:
Lin-Yu Chen, Rui-Lan Huang, Po-Hsuan Su, Ling-Hui Chu, Yu-Chun Weng, Hui-Chen Wang, Hung-Cheng Lai, Kuo-Chang Wen
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 9, p 5120 (2022)
Intraperitoneal metastasis is a challenging clinical scenario in epithelial ovarian cancer (EOC). As they are distinct from hematogenous metastasizing tumors, epithelial ovarian cancer cells primarily disseminate within the peritoneal cavity to form
Externí odkaz:
https://doaj.org/article/b3e929ba88c34c98b315adee6332e1b3
Autor:
Hung-Cheng Lai, Tim Hui-Ming Huang, Yu-Che Ou, Yu-Chun Weng, Hui-Chen Wang, Wei-Yu Lin, Ya-Ting Hsu, Tzu-I Wu, Yu-Ping Liao, Po-Hsuan Su, Rui-Lan Huang
Purpose: Endometrial cancer is a common gynecologic cancer whose incidence is increasing annually worldwide. Current methods to detect endometrial cancer are unreliable and biomarkers are unsatisfactory for screening. Cervical scrapings were reported
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ce7c09faee3bd7db2a6d44633640d43
https://doi.org/10.1158/1078-0432.c.6526116.v1
https://doi.org/10.1158/1078-0432.c.6526116.v1
Autor:
Hung-Cheng Lai, Tim Hui-Ming Huang, Yu-Che Ou, Yu-Chun Weng, Hui-Chen Wang, Wei-Yu Lin, Ya-Ting Hsu, Tzu-I Wu, Yu-Ping Liao, Po-Hsuan Su, Rui-Lan Huang
Supplementary Figure S1. Test of the methylation status of candidate genes used pooled DNA from endometrial tissues and cervical scrapings. Supplementary Figure S2. Verification of 14 candidate genes in the pilot set of cervical scrapings. Supplement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::953ac499d71c16ba3bce676aa7f6d43c
https://doi.org/10.1158/1078-0432.22467384.v1
https://doi.org/10.1158/1078-0432.22467384.v1
Autor:
Kuo-Chang Wen, Rui-Lan Huang, Lin-Yu Chen, Tzu-I Wu, Chien-Hsing Lu, Tang-Yuan Chu, Yu-Che Ou, Chen-Hsuan Wu, Shih-Tien Hsu, Dah-Ching Ding, Ling-Hui Chu, Chien-Wen Chen, Heng-Cheng Chang, Yu-Shu Liu, Hui-Chen Wang, Yu-Chun Weng, Po-Hsuan Su, Hao Lin, Hung-Cheng Lai
Publikováno v:
Cancers; Volume 14; Issue 17; Pages: 4343
Background: We describe a DNA methylation assay, named MPap test, using cervical scraping as an alternative technique for endometrial cancer detection. Methods: A multicenter hospital-based, two-stage validation study was conducted to validate the ca