Zobrazeno 1 - 10 of 29 pro vyhledávání: '"Yu Chou Tseng"'
1
Akademický článek
SOX9 is a key component of RUNX2-regulated transcriptional circuitry in osteosarcoma
Autor: Young-Im Kim, Yu-Chou Tseng, Gamze Ayaz, Shasha Wang, Hualong Yan, Wendy du Bois, Howard Yang, Tao Zhen, Maxwell P. Lee, Paul Liu, Rosandra N. Kaplan, Jing Huang
Publikováno v: Cell & Bioscience, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Background The absence of prominent, actionable genetic alternations in osteosarcomas (OS) implies that transcriptional and epigenetic mechanisms significantly contribute to the progression of this life-threatening form of cancer. Therefore,
Externí odkaz: https://doaj.org/article/2dca3bb9b8194d338a190bb1d82ddccc
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2
Akademický článek
Overcoming resistance to anabolic SARM therapy in experimental cancer cachexia with an HDAC inhibitor
Autor: Sophia G Liva, Yu‐Chou Tseng, Anees M Dauki, Michael G Sovic, Trang Vu, Sally E Henderson, Yi‐Chiu Kuo, Jason A Benedict, Xiaoli Zhang, Bryan C Remaily, Samuel K Kulp, Moray Campbell, Tanios Bekaii‐Saab, Mitchell A Phelps, Ching‐Shih Chen, Christopher C Coss
Publikováno v: EMBO Molecular Medicine, Vol 12, Iss 2, Pp 1-21 (2020)
Abstract No approved therapy exists for cancer‐associated cachexia. The colon‐26 mouse model of cancer cachexia mimics recent late‐stage clinical failures of anabolic anti‐cachexia therapy and was unresponsive to anabolic doses of diverse and
Externí odkaz: https://doaj.org/article/e590447d2f534e9b86dfa986d39f3eb8
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3
Akademický článek
CBFB cooperates with p53 to maintain TAp73 expression and suppress breast cancer.
Autor: Navdeep Malik, Hualong Yan, Howard H Yang, Gamze Ayaz, Wendy DuBois, Yu-Chou Tseng, Young-Im Kim, Shunlin Jiang, Chengyu Liu, Maxwell Lee, Jing Huang
Publikováno v: PLoS Genetics, Vol 17, Iss 5, p e1009553 (2021)
The CBFB gene is frequently mutated in several types of solid tumors. Emerging evidence suggests that CBFB is a tumor suppressor in breast cancer. However, our understanding of the tumor suppressive function of CBFB remains incomplete. Here, we analy
Externí odkaz: https://doaj.org/article/bd92132d66e74b4e8fce16a33bde98e7
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4
Dysregulation of Mitochondrial Translation Caused by CBFB Deficiency Cooperates with Mutant PIK3CA and Is a Vulnerability in Breast Cancer
Autor: Navdeep Malik, Young-Im Kim, Hualong Yan, Yu-Chou Tseng, Wendy du Bois, Gamze Ayaz, Andy D. Tran, Laura Vera-Ramirez, Howard Yang, Aleksandra M. Michalowski, Michael Kruhlak, Maxwell Lee, Kent W. Hunter, Jing Huang
Publikováno v: Cancer Research. 83:1280-1298
Understanding functional interactions between cancer mutations is an attractive strategy for discovering unappreciated cancer pathways and developing new combination therapies to improve personalized treatment. However, distinguishing driver gene pai
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0193cbcaa009ab8c86f5d66b856959cd
https://doi.org/10.1158/0008-5472.can-22-2525
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8
Fatty acid oxidation is required for embryonic stem cell survival during metabolic stress
Autor: Maxwell P. Lee, King C. Chan, Navdeep Malik, Hualong Yan, Yunlong He, Yu-Chou Tseng, Huaitian Liu, Jing Huang, Mangmang Li, Waseem Alzamzami, Joe T Nguyen, Beverly A. Mock, Wendy Dubois, Tyler J Peat, Thorkell Andresson, Lino Tessarollo, Gamze Ayaz, Young-Im Kim
Publikováno v: EMBO Rep
Metabolic regulation is critical for the maintenance of pluripotency and the survival of embryonic stem cells (ESCs). The transcription factor Tfcp2l1 has emerged as a key factor for the naive pluripotency of ESCs. Here, we report an unexpected role
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfc4511d612e3b320237d05747599494
https://europepmc.org/articles/PMC8183408/
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9
CBFB cooperates with p53 to maintain TAp73 expression and suppress breast cancer
Autor: Gamze Ayaz, Howard H. Yang, Young-Im Kim, Yu-Chou Tseng, Maxwell P. Lee, Navdeep Malik, Jing Huang, Wendy Dubois, Hualong Yan, Shunlin Jiang, Chengyu Liu
Publikováno v: PLoS Genetics
PLoS Genetics, Vol 17, Iss 5, p e1009553 (2021)
The CBFB gene is frequently mutated in several types of solid tumors. Emerging evidence suggests that CBFB is a tumor suppressor in breast cancer. However, our understanding of the tumor suppressive function of CBFB remains incomplete. Here, we analy
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0145b73bad84a4a6f4016a1407b4bc5a
https://pubmed.ncbi.nlm.nih.gov/33945523
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10
Overcoming resistance to anabolic SARM therapy in experimental cancer cachexia with an HDAC inhibitor
Autor: Samuel K. Kulp, Michael G. Sovic, Xiaoli Zhang, Tanios Bekaii-Saab, Yi Chiu Kuo, Bryan Remaily, Moray J. Campbell, Trang Vu, Anees M. Dauki, Mitchell Phelps, Jason A. Benedict, Sophia G. Liva, Christopher C. Coss, Yu Chou Tseng, Sally E. Henderson, Ching-Shih Chen
Publikováno v: EMBO Molecular Medicine, Vol 12, Iss 2, Pp n/a-n/a (2020)
EMBO Molecular Medicine
No approved therapy exists for cancer‐associated cachexia. The colon‐26 mouse model of cancer cachexia mimics recent late‐stage clinical failures of anabolic anti‐cachexia therapy and was unresponsive to anabolic doses of diverse androgens, i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22bbaecd27522bf342e0f51cb3e6044d
https://doaj.org/article/e590447d2f534e9b86dfa986d39f3eb8
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