Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Yu Chi Juang"'
Autor:
Shuhui Lim, Regina Khoo, Yu-Chi Juang, Pooja Gopal, Huibin Zhang, Constance Yeo, Khong Ming Peh, Jinkai Teo, Simon Ng, Brian Henry, Anthony W. Partridge
Publikováno v:
ACS Central Science, Vol 7, Iss 2, Pp 274-291 (2020)
Externí odkaz:
https://doaj.org/article/5f5d414c219444a1a1f0c50dacdb5325
Autor:
Anthony W. Partridge, Hung Yi Kristal Kaan, Yu-Chi Juang, Ahmad Sadruddin, Shuhui Lim, Christopher J. Brown, Simon Ng, Dawn Thean, Fernando Ferrer, Charles Johannes, Tsz Ying Yuen, Srinivasaraghavan Kannan, Pietro Aronica, Yaw Sing Tan, Mohan R. Pradhan, Chandra S. Verma, Jerome Hochman, Shiying Chen, Hui Wan, Sookhee Ha, Brad Sherborne, David P. Lane, Tomi K. Sawyer
Publikováno v:
Molecules, Vol 24, Iss 12, p 2292 (2019)
Stapled α-helical peptides represent an emerging superclass of macrocyclic molecules with drug-like properties, including high-affinity target binding, protease resistance, and membrane permeability. As a model system for probing the chemical space
Externí odkaz:
https://doaj.org/article/76dd0b05d6584b64a066db0da685651e
Autor:
Anthony W. Partridge, Simon Ng, Brian Henry, Khong Ming Peh, Jinkai Teo, Yu-Chi Juang, Pooja Gopal, Constance Yeo, Shuhui Lim, Huibin Zhang, Regina Khoo
Publikováno v:
ACS Central Science
ACS Central Science, Vol 7, Iss 2, Pp 274-291 (2020)
ACS Central Science, Vol 7, Iss 2, Pp 274-291 (2020)
Mutations to RAS proteins (H-, N-, and K-RAS) are among the most common oncogenic drivers, and tumors harboring these lesions are some of the most difficult to treat. Although covalent small molecules against KRASG12C have shown promising efficacy ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e44a90b33d5b7fecf479b41c081b0d8c
http://europepmc.org/articles/PMC7908030
http://europepmc.org/articles/PMC7908030
Autor:
Brian Henry, Shuhui Lim, Anthony W. Partridge, Pooja Gopal, Constance Yeo, Khong Ming Peh, Regina Khoo, Huibin Zhang, Jinkai Teo, Yu-Chi Juang, Simon Ng
Mutations to RAS proteins (H-, N-, and K-RAS) are amongst the most common oncogenic drivers and tumors harboring these lesions are some of the most difficult to treat. Although the recently discovered covalent small molecules against the KRASG12C mut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13fee929c6c9764db04c251fd5a8c855
https://doi.org/10.1101/2020.06.26.174565
https://doi.org/10.1101/2020.06.26.174565
Autor:
Clinton A. Taylor, Kevin W. Cormier, Shannon E. Keenan, Svetlana Earnest, Steve Stippec, Chonlarat Wichaidit, Yu-Chi Juang, Junmei Wang, Stanislav Y. Shvartsman, Elizabeth J. Goldsmith, Melanie H. Cobb
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 116(31)
The most frequent extracellular signal-regulated kinase 2 (ERK2) mutation occurring in cancers is E322K (E-K). ERK2 E-K reverses a buried charge in the ERK2 common docking (CD) site, a region that binds activators, inhibitors, and substrates. Little
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73713b8a4cfbee526c412aea6c92a1da
https://pubmed.ncbi.nlm.nih.gov/31296562
https://pubmed.ncbi.nlm.nih.gov/31296562
Autor:
Charles W. Johannes, Tomi K. Sawyer, Srinivasaraghavan Kannan, Nils A. Berglund, Yu-Chi Juang, Xue’Er Cheryl Lee, Hung Yi Kristal Kaan, Chandra S. Verma, Simon Ng, Alexander Stoeck, Liew Xi, Anthony W. Partridge, Lijuan Liu, David P. Lane, Arun Chandramohan, Fernando J. Ferrer, Tsz Ying Yuen, Ahmad Sadruddin, Pietro G. A. Aronica, Christopher J. Brown
Publikováno v:
ACS Med Chem Lett
Discovery of false-positive target binding, due to assay interference or aggregation, presents a significant problem for drug discovery programs. These issues may often be unrealized and could lead researchers astray if not subject to independent ver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a00b04284e3ebf74d3ee850f11be050
Publikováno v:
SLAS discovery : advancing life sciences RD. 23(9)
Histidine decarboxylase (HDC) is the primary enzyme that catalyzes the conversion of histidine to histamine. HDC contributes to many physiological responses as histamine plays important roles in allergic reaction, neurological response, gastric acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56b735920e74fc668e8f079c6263e92e
https://pubmed.ncbi.nlm.nih.gov/29884090
https://pubmed.ncbi.nlm.nih.gov/29884090
Autor:
Yaw Sing Tan, Andrea M. Peier, Anthony W. Partridge, Hung Yi Kristal Kaan, Laura Surdi, Tsz Ying Yuen, Tomi K. Sawyer, Srinivasaraghavan Kannan, Shiying Chen, Berengere Sauvagnat, Jerome Hochman, Shuhui Lim, Peter J. Dandliker, Chandra S. Verma, David P. Lane, Pietro G. A. Aronica, Christopher J. Brown, Charles W. Johannes, Simon Ng, Yu-Chi Juang, Brad Sherborne, Fernando J. Ferrer, Sookhee Ha
Publikováno v:
Bioorganicmedicinal chemistry. 26(10)
Macrocyclic α-helical peptides have emerged as a compelling new therapeutic modality to tackle targets confined to the intracellular compartment. Within the scope of hydrocarbon-stapling there has been significant progress to date, including the fir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5dc064449548c54b9dee52116315e6c
https://pubmed.ncbi.nlm.nih.gov/29598901
https://pubmed.ncbi.nlm.nih.gov/29598901
Autor:
Shawn, Xiong, Kristina, Lorenzen, Amber L, Couzens, Catherine M, Templeton, Dushyandi, Rajendran, Daniel Y L, Mao, Yu-Chi, Juang, David, Chiovitti, Igor, Kurinov, Sebastian, Guettler, Anne-Claude, Gingras, Frank, Sicheri
Publikováno v:
Structure(London, England:1993)
Summary The human NDR family kinases control diverse aspects of cell growth, and are regulated through phosphorylation and association with scaffolds such as MOB1. Here, we report the crystal structure of the human NDR1 kinase domain in its non-phosp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d3e41c7b473ca024550a35d461048131
https://pubmed.ncbi.nlm.nih.gov/29983373
https://pubmed.ncbi.nlm.nih.gov/29983373
Autor:
Stephen Orlicky, Derek F. Ceccarelli, Christina Gaughan, Robert H. Silverman, Babal K. Jha, Hao Huang, Yu-Chi Juang, Monica C. Pillon, Neroshan Thevakumaran, Beihua Dong, Manisha Talukdar, Frank Sicheri, Margo A. Brinton, Nicole M. Duffy, Daniel Y.L. Mao, Igor Kourinov, Alba Guarné, Leo C. K. Wan, Andrey A. Perelygin, Elton Zeqiraj
Publikováno v:
Molecular Cell
RNase L is an ankyrin repeat domain containing dual endoribonuclease-pseudokinase that is activated by unusual 2′,5′-oligoadenylate (2-5A) second messengers and which impedes viral infections in higher vertebrates. Despite its importance in inter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1134ce388181d248329ed2844be40a56
https://doi.org/10.1016/j.molcel.2013.12.025
https://doi.org/10.1016/j.molcel.2013.12.025