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Akademický článek

Helicobacter pylori chemoreceptor TlpC mediates chemotaxis to lactate

Autor: Mayra A. Machuca, Kevin S. Johnson, Yu C. Liu, David L. Steer, Karen M. Ottemann, Anna Roujeinikova

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)

Abstract It is recently appreciated that many bacterial chemoreceptors have ligand-binding domains (LBD) of the dCACHE family, a structure with two PAS-like subdomains, one membrane-proximal and the other membrane-distal. Previous studies had implica

Externí odkaz: https://doaj.org/article/70d3bd8e624444ddaa9c81528f895161

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A Functional-group Based 'Artificial' Activity Coefficient Model for Droplet Evaporation (AACM-DE) of Complex Fuel

Autor: Yu C. Liu, Lei Luo

Publikováno v: AIAA Propulsion and Energy 2021 Forum.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::82f77a41d30074df36b34e4bb2f96cf3
https://doi.org/10.2514/6.2021-3628

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Perturbations of genes essential for Müllerian duct and Wölffian duct development in Mayer-Rokitansky-Küster-Hauser syndrome

Autor: Chen, N. Zhao, S. Jolly, A. Wang, L. Pan, H. Yuan, J. Chen, S. Koch, A. Ma, C. Tian, W. Jia, Z. Kang, J. Zhao, L. Qin, C. Fan, X. Rall, K. Coban-Akdemir, Z. Chen, Z. Jhangiani, S. Liang, Z. Niu, Y. Li, X. Yan, Z. Wu, Y. Dong, S. Song, C. Qiu, G. Zhang, S. Liu, P. Posey, J.E. Zhang, F. Luo, G. Wu, Z. Zhang, T.J. Wu, N. Wang, S. Liu, J. Liu, S. Zuo, Y. Liu, G. Yu, C. Liu, L. Shao, J. Zhao, H. Wang, H. Liu, B. Cheng, X. Lin, J. Du, H. Li, Y. Song, S. Xie, Z. Zhao, Z. Zhao, Z. Zheng, Z. Huang, Y. Su, J. Zhang, J. Chen, E.Y. Rouskas, K. Glentis, S. Bacopoulou, F. Deligeoroglou, E. Chrousos, G. Lyonnet, S. Polak, M. Rosenberg, C. Dingeldein, I. Bonilla, X. Borel, C. Gibbs, R.A. Dietrich, J.E. Dimas, A.S. Antonarakis, S.E. Brucker, S.Y. Lupski, J.R. Zhu, L. Deciphering Disorders Involving Scoliosis COmorbidities (DISCO) study group

Mayer-Rokitansky-Küster-Hauser syndrome (MRKHS) is associated with congenital absence of the uterus, cervix, and the upper part of the vagina; it is a sex-limited trait. Disrupted development of the Müllerian ducts (MD)/Wölffian ducts (WD) through

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2127::fd4f89e2e644e5bff6e22c223da116c5
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3076279

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Recurrent ZNF83-E293V Mutation Promotes Bladder Cancer Progression through the NF-κB Pathway via Transcriptional Dysregulation of S100A8

Autor: Miao Chen, Yu Zhang, Chen Jiang, Sha Y. Wu, Yi Z. Jia, Feng Wang, Qian Yan, Yu C. Liu, Jin L. Huang, Zhao J. Lyu, Lei Li, Xin Y. Guan, Ya C. Chen, Zhi M. Cai, Hong B. Mei, Xiang Lin, Ying Wang, Ying Tang, Ren H. Li

Publikováno v: Molecular Therapy

Urothelial carcinoma (UC) is the predominant form of bladder cancer. Significant molecular heterogeneity caused by diverse molecular alterations brings about large variations in the response to treatment in UC. An improved understanding of the geneti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1584c7fbb911a9f2fe1a08280767395b
https://pubmed.ncbi.nlm.nih.gov/33002420

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Structure–Activity Relationship for Sulfonamide Inhibition of Helicobacter pylori α-Carbonic Anhydrase

Autor: Joyanta K. Modak, Claudiu T. Supuran, Yu C. Liu, Anna Roujeinikova

Publikováno v: Journal of Medicinal Chemistry. 59:11098-11109

α-Carbonic anhydrase of Helicobacter pylori (HpαCA) plays an important role in the acclimation of this oncobacterium to the acidic pH of the stomach. Sulfonamide inhibitors of HpαCA possess anti-H. pylori activity. The crystal structures of comple

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::600495cdd00442291f76fb4707f37f0d
https://doi.org/10.1021/acs.jmedchem.6b01333

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Helicobacter pylori chemoreceptor TlpC mediates chemotaxis to lactate

Autor: Anna Roujeinikova, David Steer, Kevin S. Johnson, Karen M. Ottemann, Mayra A. Machuca, Yu C. Liu

Publikováno v: Scientific reports, vol 7, iss 1
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Scientific Reports

It is recently appreciated that many bacterial chemoreceptors have ligand-binding domains (LBD) of the dCACHE family, a structure with two PAS-like subdomains, one membrane-proximal and the other membrane-distal. Previous studies had implicated only

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35386a61d43b41210f06190df00133de
https://escholarship.org/uc/item/7cv8p5kj

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Cloning, purification and preliminary crystallographic analysis of theHelicobacter pyloripseudaminic acid biosynthesisN-acetyltransferase PseH

Autor: Abu Iftiaf Md Salah Ud-Din, Anna Roujeinikova, Yu C. Liu

Publikováno v: Acta Crystallographica Section F Structural Biology Communications. 70:1276-1279

Helicobacter pyloriinfection is the common cause of gastritis and duodenal and stomach ulcers, which have been linked to a higher risk of the development of gastric cancer. The motility that facilitates persistent infection requires functional flagel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07ecfa5148f53df89c262ebe495ac895
https://doi.org/10.1107/s2053230x14015398

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The crystal structure of the tandem-PAS sensing domain of Campylobacter jejuni chemoreceptor Tlp1 suggests indirect mechanism of ligand recognition

Autor: Yu C. Liu, Anna Roujeinikova, Simone A. Beckham, Mayra A. Machuca, Menachem J. Gunzburg

Publikováno v: Journal of structural biology. 194(2)

Chemotaxis and motility play an important role in the colonisation of avian and human hosts by Campylobacter jejuni. Chemotactic recognition of extracellular signals is mediated by the periplasmic sensing domain of methyl-accepting chemotactic protei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ae9c8b28413bc0eee9b733a8cac4842
https://pubmed.ncbi.nlm.nih.gov/26923153

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Structural basis for amino-acid recognition and transmembrane signalling by tandem Per-Arnt-Sim (tandem PAS) chemoreceptor sensory domains

Autor: Anna Roujeinikova, Yu C. Liu, Mayra A. Machuca, Menachem J. Gunzburg, Simone A. Beckham

Publikováno v: Acta crystallographica. Section D, Biological crystallography. 71(Pt 10)

Chemotaxis, mediated by methyl-accepting chemotaxis protein (MCP) receptors, plays an important role in the ecology of bacterial populations. This paper presents the first crystallographic analysis of the structure and ligand-induced conformational c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6292fe63f9a2d6e2d6a0536de3c4c971
https://pubmed.ncbi.nlm.nih.gov/26457436

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Structural Basis for the Inhibition of Helicobacter pylori α-Carbonic Anhydrase by Sulfonamides

Autor: Anna Roujeinikova, Claudiu T. Supuran, Yu C. Liu, Mayra A. Machuca, Joyanta K. Modakh

Publikováno v: PLoS ONE
PLoS ONE, Vol 10, Iss 5, p e0127149 (2015)

Periplasmic α-carbonic anhydrase of Helicobacter pylori (HpαCA), an oncogenic bacterium in the human stomach, is essential for its acclimation to low pH. It catalyses the conversion of carbon dioxide to bicarbonate using Zn(II) as the cofactor. In

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9cfbfefc57ee794a3a136f7bf75785c
http://europepmc.org/articles/PMC4444264

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