Zobrazeno 1 - 10
of 176
pro vyhledávání: '"Yu Hara"'
Autor:
Kohei Somekawa, Keisuke Watanabe, Kenichi Seki, Suguru Muraoka, Ami Izawa, Ayami Kaneko, Yukiko Otsu, Momo Hirata, Sousuke Kubo, Katsushi Tanaka, Ryo Nagasawa, Hiromi Matsumoto, Kota Murohashi, Hiroaki Fuji, Ayako Aoki, Nobuyuki Horita, Yu Hara, Nobuaki Kobayashi, Makoto Kudo, Takeshi Kaneko
Publikováno v:
European Clinical Respiratory Journal, Vol 11, Iss 1 (2024)
Background Biologics are the important drugs for severe asthma, but clinical trials included few elderly patients. Data on the safety and efficacy of benralizumab in elderly asthma patients are limited.Methods This clinical study was a multicentre, r
Externí odkaz:
https://doaj.org/article/3a61695cb0444719be9e00172eb6d4dd
Autor:
Nobuaki Kobayashi, Hiromi Matsumoto, Kohei Somekawa, Ayami Kaneko, Nobuhiko Fukuda, Suguru Muraoka, Yukiko Ohtsu, Momo Hirata, Ryo Nagasawa, Sousuke Kubo, Kota Murohashi, Hiroaki Fujii, Ayako Aoki, Keisuke Watanabe, Nobuyuki Horita, Yu Hara, Takeshi Kaneko
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Benralizumab, a monoclonal antibody targeting IL-5 receptors, reduces exacerbations and oral corticosteroid requirements for severe, uncontrolled eosinophilic asthma. In Japan, geographic disparities in asthma outcomes suggest differential p
Externí odkaz:
https://doaj.org/article/8a23af9f1a724ed69d43d34d79739f8c
Autor:
Ayami Kaneko, Nobuaki Kobayashi, Kenji Miura, Hiromi Matsumoto, Kohei Somekawa, Tomofumi Hirose, Yukihito Kajita, Anna Tanaka, Shuhei Teranishi, Yu Sairenji, Hidetoshi Kawashima, Kentaro Yumoto, Toshinori Tsukahara, Nobuhiko Fukuda, Ryuichi Nishihira, Keisuke Watanabe, Nobuyuki Horita, Yu Hara, Makoto Kudo, Naoki Miyazawa, Takeshi Kaneko
Publikováno v:
Thoracic Cancer, Vol 15, Iss 15, Pp 1208-1217 (2024)
Abstract Background For advanced non‐small cell lung cancer (NSCLC), combination therapies including a PD‐1 inhibitor plus chemotherapy or a PD‐1 inhibitor, CTLA‐4 inhibitor, and chemotherapy are standard first‐line options. However, data d
Externí odkaz:
https://doaj.org/article/a735d5e5686648739b1e27925239e9be
Autor:
Momo Hirata, Yu Hara, Hiroaki Fujii, Kota Murohashi, Yusuke Saigusa, Shiqi Zhao, Miyu Kobayashi, Ryo Nagasawa, Yoichi Tagami, Ami Izawa, Yukiko Otsu, Keisuke Watanabe, Nobuyuki Horita, Nobuaki Kobayashi, Takeshi Kaneko
Publikováno v:
BMC Pulmonary Medicine, Vol 24, Iss 1, Pp 1-11 (2024)
Abstract Background The ILD-GAP scoring system is known to be useful in predicting prognosis in patients with interstitial lung disease (ILD). An elevated monocyte count was associated with increased risks of IPF poor prognosis. We examined whether t
Externí odkaz:
https://doaj.org/article/8ac8e50f41ef409e95e09ec1c5a8f4a9
Autor:
Yoichi Tagami, Yu Hara, Kota Murohashi, Ryo Nagasawa, Hiroaki Fujii, Ami Izawa, Aya Yabe, Yusuke Saigusa, Miyu Kobayashi, Masafumi Shiida, Momo Hirata, Yukiko Otsu, Keisuke Watanabe, Nobuyuki Horita, Nobuaki Kobayashi, Takeshi Kaneko
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract Serum heme oxygenase (HO)-1 level has been reported as a clinically reliable diagnostic biomarker for acute exacerbation of interstitial lung disease (ILD); however, its utility for predicting mortality among these patients is unclear. Serum
Externí odkaz:
https://doaj.org/article/66c3840d6e1d40528da6d93c65c5882f
Autor:
Nobuyuki Hirama, Masaki Yamamoto, Satoshi Nagaoka, Wataru Segawa, Chihiro Sugimoto, Hirokazu Nagayama, Shuntaro Hiro, Yukihito Kajita, Chihiro Maeda, Sousuke Kubo, Kenichi Seki, Yoshinori Nagahara, Shuhei Teranishi, Ken Tashiro, Yu Hara, Nobuaki Kobayashi, Shigenobu Watanabe, Makoto Kudo, Takeshi Kaneko
Publikováno v:
Thoracic Cancer, Vol 14, Iss 25, Pp 2601-2607 (2023)
Abstract Background Based on the results of the PACIFIC trial, maintenance with durvalumab has emerged as the standard treatment following concurrent chemoradiotherapy in patients with unresectable locally advanced non‐small cell lung carcinoma (NS
Externí odkaz:
https://doaj.org/article/9ea55ed2cec44c0b9c3c0f13da150dab
Autor:
Hiromi Matsumoto, Taichi Fukushima, Nobuaki Kobayashi, Yuuki Higashino, Suguru Muraoka, Yukiko Ohtsu, Momo Hirata, Kohei Somekawa, Ayami Kaneko, Ryo Nagasawa, Sousuke Kubo, Katsushi Tanaka, Kota Murohashi, Hiroaki Fujii, Keisuke Watanabe, Nobuyuki Horita, Yu Hara, Takeshi Kaneko
Publikováno v:
PLoS ONE, Vol 19, Iss 8, p e0299760 (2024)
BackgroundImmune checkpoint inhibitors (ICIs) have improved outcomes in cancer treatment but are also associated with adverse events and financial burdens. Identifying accurate biomarkers is crucial for determining which patients are likely to benefi
Externí odkaz:
https://doaj.org/article/2eee71d6b23e44f4881ae7b437149737
Publikováno v:
The Clinical Respiratory Journal, Vol 17, Iss 4, Pp 303-310 (2023)
Abstract Background The clinical features of asthma with connective tissue diseases (CTDs) are not well‐known. This study therefore aimed to investigate the clinical characteristics of asthma with CTDs. Methods We retrospectively examined the recor
Externí odkaz:
https://doaj.org/article/dfc429735d0d4f1eb0d3163fa978d46b
Autor:
Hiromi Matsumoto, Nobuaki Kobayashi, Satoru Shinoda, Atsushi Goto, Ayami Kaneko, Nobuhiko Fukuda, Chisato Kamimaki, Sousuke Kubo, Keisuke Watanabe, Nobuyuki Horita, Yu Hara, Yoshihiro Ishikawa, Takeshi Kaneko
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) are extensively used in the treatment of non-small cell lung cancer (NSCLC); hence, equal access to them is important. Therefore, this study aimed to identify regional d
Externí odkaz:
https://doaj.org/article/8153af7c246f465a84d232c58da93bf0
Autor:
Soichiro Suzuki, Fumiaki Ando, Sae Kitagawa, Yu Hara, Tamami Fujiki, Shintaro Mandai, Koichiro Susa, Takayasu Mori, Eisei Sohara, Tatemitsu Rai, Shinichi Uchida
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)
ZNF185 is identified as a novel PKA substrate and found to be important for the organization of endothelial cell–cell junctions and suppression of vascular hyperpermeability by regulating the cAMP/PKA/RhoA signaling pathway.
Externí odkaz:
https://doaj.org/article/8f63103e0820459da3615d3e0e88138a