Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Yu Gui Gu"'
Autor:
Xiaojun Wang, Andrew L. Adler, Andrew R. Lisowski, Heidi S. Camp, Bradley A. Zinker, Jeffrey F. Waring, Scott E. Warder, Teresa Mcnally, Yi Yang, Yu Gui Gu, Xiangdong Xu, Eric A.G. Blomme, Moshe Weitzberg, Robert Dickinson, Christine H Healan-Greenberg
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 324:507-516
Acetyl CoA carboxylase (ACC) 2, which catalyzes the carboxylation of acetyl-CoA to form malonyl-CoA, has been identified as a potential target for type 2 diabetes and obesity. Small-molecule inhibitors of ACC2 would be expected to reduce de novo lipi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b6ce83ab778b186c59ca2fd92bba088
https://doi.org/10.1124/jpet.107.126938
https://doi.org/10.1124/jpet.107.126938
Autor:
Tianyuan Zhang, Richard A. G. Smith, Rohinton Edalji, Yu-Gui Gu, John L. Baranowski, William J. Sanders, Bruce A. Beutel, Liping Yu, Philip J. Hajduk, Annapur Gurulingappa Shivakumar, Stephan J. Kakavas, Frank L. Wagenaar, Darlene J. Balli, Steven F. Betz, Richard F. Clark, Kenneth M. Comess, Eric J. Hebert, J. Owen McCall, Jamey Mack, Linda E. Chovan, Randy E. Metzger, Thomas F. Holzman, Anne Y. Saiki, Sarah A. Dorwin, Niru B. Soni, Mai Bui, Angela M. Nilius, Susan J. Thornewell, Cooper Curt S, Mark E. Schurdak, Michael L. Coen, Rolf Wagner, Alan S. Florjancic, Philip J. Merta, Claude G. Lerner, Charlotte Woodall, Candace Black-Schaefer, John E. Harlan, Mengli Cai, Karl A. Walter, Xenia B. Searle, Stephen W. Fesik
Publikováno v:
Chemical Biology & Drug Design. 69:395-404
As part of a fully integrated and comprehensive strategy to discover novel antibacterial agents, NMR- and mass spectrometry-based affinity selection screens were performed to identify compounds that bind to protein targets uniquely found in bacteria
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d5518c2506c2d9a00a67d68a32abac6
https://doi.org/10.1111/j.1747-0285.2007.00521.x
https://doi.org/10.1111/j.1747-0285.2007.00521.x
Autor:
Bruce A. Beutel, T. Matthew Hansen, Tianyuan Zhang, Rongqi Wang, Hing L. Sham, Xiaojun Wang, Yu Gui Gu, Ying Wang, Gang Liu, Ernst U. Frevert, Richard F. Clark, Xiaolin Zhang, Heidi S. Camp, Zhili Xin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:6078-6081
Structure-activity relationships for a recently discovered thiazolyl phenyl ether series of acetyl-CoA carboxylase (ACC) inhibitors were investigated. Preliminary efforts to optimize the series through modification of the distal aryl ether moiety of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9999e4ea9913427411e2084136d89b48
https://doi.org/10.1016/j.bmcl.2006.08.100
https://doi.org/10.1016/j.bmcl.2006.08.100
Autor:
Kenton L. Longenecker, Karl A. Walter, Rohinton Edalji, John E. Harlan, Diane Bartley, Philip J. Hajduk, Larry R. Solomon, Thomas F. Holzman, Geoffrey F. Stamper, Yu Gui Gu, Vincent S. Stoll, Claude G. Lerner, Bruce A. Beutel, Elizabeth H. Fry, Clarissa G. Jakob
Publikováno v:
Protein Science. 14:3039-3047
In a broad genomics analysis to find novel protein targets for antibiotic discovery, MurF was identified as an essential gene product for Streptococcus pneumonia that catalyzes a critical reaction in the biosynthesis of the peptidoglycan in the forma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b06c072a2f62481b44713f237f720cb
https://doi.org/10.1110/ps.051604805
https://doi.org/10.1110/ps.051604805
Autor:
Angela M. Nilius, Yu-Gui Gu, Tamara Rehm, Mai H. Bui, Peter J. Dandliker, Bruce A. Beutel, T. Matthew Hansen, Linda E. Chovan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:2716-2719
A series of 5-methoxy- and 5-hydroxy-6-fluoro-1,8-naphthyridone-3-carboxylic acid derivatives were prepared and evaluated for cell-free bacterial protein synthesis inhibition and whole cell antibacterial activity. When compared to the analogous 5-hyd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e3637a6908cb60f0759027f2d716168
https://doi.org/10.1016/j.bmcl.2005.04.007
https://doi.org/10.1016/j.bmcl.2005.04.007
Publikováno v:
Tetrahedron Letters. 41:9397-9401
A synthesis of funiculosin dimethyl ether (2) is described. Methodologies for an asymmetric conjugate addition to establish the 1,3-anti dimethyl array, stereocontrolled formation of the Z,E-bis-allylic C-11 alcohol, and interception of a reactive py
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69d9b64642c6b87aaaf5244c5e5365bf
https://doi.org/10.1016/s0040-4039(00)01496-9
https://doi.org/10.1016/s0040-4039(00)01496-9
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:1341-1346
A tetracyclic compound of the formula: ##STR1## wherein A and the atoms to which it is attached comprise a pyridine ring selected from: ##STR2## wherein R 1 , R 2 , and R 3 are specifically defined, which compounds are useful in the treatment of dopa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e74f6c4ae181c08ae6088b4e11469e1
https://doi.org/10.1016/s0960-894x(99)00214-0
https://doi.org/10.1016/s0960-894x(99)00214-0
Publikováno v:
Tetrahedron Letters. 38:331-334
The use of bromotrichloromethane-DBU is described for the selective oxidative conversion of several dihydro-heterocyclic systems to the corresponding heteroaromatics. Oxidative dehydrogenations to afford 4-hydroxy-2-pyridinones are examined under a v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d7d95452b4f33d51b84c778d6b2a2c4
https://doi.org/10.1016/s0040-4039(96)02344-1
https://doi.org/10.1016/s0040-4039(96)02344-1
Publikováno v:
Tetrahedron Letters. 38:327-330
Internal enolate condensations, utilizing carboxamidimidazoles as activated ureas, provide a general synthesis of the 3,5-disubstituted-4-hydroxy-2-pyridinone 2 as found in funiculosin. The novel all-syn-cyclitol, C-liniked to the heterocyclic system
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::074a6bc1423ccacef084303c2dd28bc7
https://doi.org/10.1016/s0040-4039(96)02343-x
https://doi.org/10.1016/s0040-4039(96)02343-x
Publikováno v:
Organicbiomolecular chemistry. 11(28)
Herein we report a direct and efficient method for the synthesis of four new carboxylate-isostere analogs of daptomycin. The side chain carboxylic acid moieties of the aspartic acids (Asp-3, Asp-7 and Asp-9) and β-methyl glutamic acid (MeGlu-12) wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb48f77dd5f03ae457a6f4980bd4e118
https://pubmed.ncbi.nlm.nih.gov/23752953
https://pubmed.ncbi.nlm.nih.gov/23752953