Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Yu‐shin Sou"'
Autor:
Shun Kageyama, Sigurdur Runar Gudmundsson, Yu-Shin Sou, Yoshinobu Ichimura, Naoki Tamura, Saiko Kazuno, Takashi Ueno, Yoshiki Miura, Daisuke Noshiro, Manabu Abe, Tsunehiro Mizushima, Nobuaki Miura, Shujiro Okuda, Hozumi Motohashi, Jin-A Lee, Kenji Sakimura, Tomoyuki Ohe, Nobuo N. Noda, Satoshi Waguri, Eeva-Liisa Eskelinen, Masaaki Komatsu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Liquid-liquid phase separation of p62/SQSTM1 has been previously described, although the significance in vivo remains unclear. Here the authors show p62 droplets contain ubiquitin, autophagy-related proteins and Keap1 to serve as platform of not only
Externí odkaz:
https://doaj.org/article/50de4fe4211844b99cf42f1bafec73c8
Golgi pH homeostasis stabilizes the lysosomal membrane through N-glycosylation of membrane proteins.
Publikováno v:
Life Science Alliance; Oct2024, Vol. 7 Issue 10, p1-18, 18p
Autor:
Yu‐shin Sou, Junji Yamaguchi, Hiroshi Kameda, Keisuke Masuda, Yusuke Maeda, Yasuo Uchiyama, Masato Koike
Publikováno v:
FEBS lettersReferences. 596(22)
The Golgi pH regulator (GPHR) is essential for maintaining the function and morphology of the Golgi apparatus through the regulation of luminal acidic pH. Abnormal morphology of the Golgi apparatus is associated with neurodegenerative diseases. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21714d7d4780bad50587a05ebc96ed53
https://pubmed.ncbi.nlm.nih.gov/36056653
https://pubmed.ncbi.nlm.nih.gov/36056653
Autor:
Faruk Mohammad Omar, Masaaki Komatsu, Masato Koike, Nobuo N. Noda, Yu-shin Sou, Shun Kageyama, Afnan H. El-Gowily, Yoshinobu Ichimura
SummaryA series of amyotrophic lateral sclerosis (ALS)-related proteins such as FUS, TDP-43 and hnRNPA1 has an ability to be liquid-liquid phase separation, and their disease-related mutations cause the transition of their responsible liquid droplets
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ffd3ca5850d0c5f73d03a7109a7fdd9a
https://doi.org/10.1101/2021.06.07.447422
https://doi.org/10.1101/2021.06.07.447422
Autor:
Satoko Komatsu-Hirota, Yu-shin Sou, Masaaki Komatsu, Mohammad Omar Faruk, Nobuo N. Noda, Shun Kageyama, Yoshinobu Ichimura, Afnan H. El-Gowily, Masato Koike
Publikováno v:
The Journal of Biological Chemistry
Summary Several amyotrophic lateral sclerosis (ALS)-related proteins such as FUS, TDP-43, and hnRNPA1 demonstrate liquid-liquid phase separation, and their disease-related mutations correlate with a transition of their liquid droplet form into aggreg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b9984bac28fcd074c4fc72342ddc213
https://pubmed.ncbi.nlm.nih.gov/34774801
https://pubmed.ncbi.nlm.nih.gov/34774801
Autor:
Masaaki Komatsu, Masato Koike, Pablo Sánchez-Martín, Satoshi Waguri, Yu-shin Sou, Shun Kageyama
Publikováno v:
EMBO Rep
p62/SQSTM1 is a multivalent protein that has the ability to cause liquid–liquid phase separation and serves as a receptor protein that participates in cargo isolation during selective autophagy. This protein is also involved in the non‐canonical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aea6fbd4f6d0ac6f78335ca013f3da5d
https://doi.org/10.15252/embr.201948902
https://doi.org/10.15252/embr.201948902
Autor:
Akiko Kuma, Masato Koike, Shuji Terai, Makoto Suematsu, Shun saku Takahashi, Takayuki Yabe, Tetsuya Saito, Satoshi Waguri, Yu-shin Sou, Masaaki Komatsu, Takehiko Yokomizo, Noboru Mizushima, Yuki Sugiura, Hyeon-Cheol Lee
Publikováno v:
Life Science Alliance
Autophagy regulates fatty acid and triglyceride synthesis at the transcriptional level by fine-tuning the levels of NCoR1, a negative regulator of nuclear receptors. Defective autophagy impairs physiological steatosis both under fasting conditions an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9d46833c593ff04e76b966a3c6efbc0
http://europepmc.org/articles/PMC6932742
http://europepmc.org/articles/PMC6932742
Autor:
Noboru Mizushima, Takayuki Yabe, Masaaki Komatsu, Satoshi Waguri, Yu-shin Sou, Tetsuya Saito, Akiko Kuma, Masato Koike, Shuji Terai, Shunsaku Takahashi
Lipid droplets (LDs) are dynamic organelles that store neutral lipids during times of energy excess, such as following a meal. LDs serve as an energy reservoir during fasting and have a buffering capacity that prevents lipotoxicity. Autophagy and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f6219dc16ca48970b6f1f3af8979117
p62/SQSTM1 is a multivalent protein that has an ability to cause a liquid-liquid phase separation and serves as a receptor protein that participates in cargo isolation during selective autophagy. This protein is also involved in the non-canonical act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef1bca3706a299eb552c49e12e990303
https://doi.org/10.1101/709105
https://doi.org/10.1101/709105
Autor:
Yasuo Uchiyama, Kazue Niisato, Soichiro Kakuta, Noboru Suzuki, Laxmi Kumar Parajuli, Yu-shin Sou, Kenji Sakimura, Isei Tanida, Taroh Kinoshita, Yusuke Maeda, Takashi Sakurai, Yuji Kamikubo, Hiromitsu Saito, Masato Koike
Publikováno v:
eNeuro
The Golgi apparatus plays an indispensable role in posttranslational modification and transport of proteins to their target destinations. Although it is well established that the Golgi apparatus requires an acidic luminal pH for optimal activity, mor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57a5bf90c8c507fe6be003c39a217c03
https://pubmed.ncbi.nlm.nih.gov/31118204
https://pubmed.ncbi.nlm.nih.gov/31118204