Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Yu‐ming M. Huang"'
Autor:
Rezvan Shahoei, Susheel Pangeni, Matthew A. Sanders, Huamei Zhang, Ljiljana Mladenovic-Lucas, William R. Roush, Geoff Halvorsen, Christopher V. Kelly, James G. Granneman, Yu-ming M. Huang
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Alpha/beta hydrolase domain-containing 5 (ABHD5), also termed CGI-58, is the key upstream activator of adipose triglyceride lipase (ATGL), which plays an essential role in lipid metabolism and energy storage. Mutations in ABHD5 disrupt lipolysis and
Externí odkaz:
https://doaj.org/article/9ffe90bd7ed04d6683a402c04c7ccf99
Autor:
Timothy Hasse, Esra Mantei, Rezvan Shahoei, Shristi Pawnikar, Jinan Wang, Yinglong Miao, Yu-Ming M Huang
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 3, p e1011955 (2024)
The COVID-19 pandemic, driven by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spurred an urgent need for effective therapeutic interventions. The spike glycoprotein of the SARS-CoV-2 is crucial for infiltrating host cells, re
Externí odkaz:
https://doaj.org/article/c9e29beee822449486e16f6f3607c35c
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 91:555-566
Interactions between the meiosis expressed gene 1 (MEIG1) and Parkin co-regulated gene (PACRG) protein are critical in the formation of mature sperm cells. Targeting either MEIG1 or PACRG protein could be a contraceptive strategy. The W50A and Y68A m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e8432f2c55adc6c721762bf6164af88
https://doi.org/10.1002/prot.26449
https://doi.org/10.1002/prot.26449
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 91
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71c27d84a96fb05fc08be3b982a3639e
https://doi.org/10.1002/prot.26483
https://doi.org/10.1002/prot.26483
Autor:
Pattaraporn Thepsuwan, Asmita Bhattacharya, Zhenfeng Song, Stephen Hippleheuser, Shaobin Feng, Xiaoqiong Wei, Nupur K. Das, Mariana Sierra, Juncheng Wei, Deyu Fang, Yu-ming M. Huang, Kezhong Zhang, Yatrik M. Shah, Shengyi Sun
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 120(2)
Iron homeostasis is critical for cellular and organismal function and is tightly regulated to prevent toxicity or anemia due to iron excess or deficiency, respectively. However, subcellular regulatory mechanisms of iron remain largely unexplored. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a8468f9ce04638d2bc3b243eaab319d
https://pubmed.ncbi.nlm.nih.gov/36595688
https://pubmed.ncbi.nlm.nih.gov/36595688
Publikováno v:
Chemical Research in Toxicology. 34:1140-1149
Benzophenone-1 (BP-1), one of the commonly used ultraviolet filters, has caused increasing public concern due to frequently detected residues in environmental and recreational waters. Its susceptibility to residual chlorine and the potential to subse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::905013fd3248636dd9ae5b63653e3a95
https://doi.org/10.1021/acs.chemrestox.1c00023
https://doi.org/10.1021/acs.chemrestox.1c00023
Autor:
Christian D. Ellson, Ingred Goretti Riça, Jacob S. Kim, Yu-ming M Huang, Daniel Lim, Tanya Mitra, Albert Hsu, Erin X. Wei, Christopher D. Barrett, Leo E. Otterbein, Carl J. Hauser, Martin Wahl, Heinrich Delbrück, Udo Heinemann, Hartmut Oschkinat, Chia-en A. Chang, Michael B. Yaffe
Publikováno v:
Journal of molecular biology. 434(9)
The neutrophil NADPH oxidase produces both intracellular and extracellular reactive oxygen species (ROS). Although oxidase activity is essential for microbial killing, and ROS can act as signaling molecules in the inflammatory process, excessive extr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cde168e62d5a3f408de06578d560929
https://pubmed.ncbi.nlm.nih.gov/35314146
https://pubmed.ncbi.nlm.nih.gov/35314146
Autor:
Giulia Palermo, Yu-ming M. Huang, Yinglong Miao, Jinan Wang, Rohaine V. Hsu, Pablo Ricardo Arantes, Apurba Bhattarai, Shristi Pawnikar
Publikováno v:
Wiley Interdiscip Rev Comput Mol Sci
Gaussian accelerated molecular dynamics (GaMD) is a robust computational method for simultaneous unconstrained enhanced sampling and free energy calculations of biomolecules. It works by adding a harmonic boost potential to smooth biomolecular potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da93e103eb7a508bc94eed37919d8888
https://pubmed.ncbi.nlm.nih.gov/34899998
https://pubmed.ncbi.nlm.nih.gov/34899998
Publikováno v:
Chemical Biology & Drug Design. 93:647-652
To maintain the lipid asymmetry of the cell envelope in Gram-negative bacteria, the MlaC protein serves as a lipid-transfer factor and delivers phospholipids from the outer to the inner membrane. A strategy of antibiotic discovery is to design a prop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::430370e6eb56791a2084b09502149bec
https://doi.org/10.1111/cbdd.13462
https://doi.org/10.1111/cbdd.13462
Autor:
Yu-Ming M Huang, Chia-En A Chang
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e98291 (2014)
The regulation of a series of cellular events requires specific protein-protein interactions, which are usually mediated by modular domains to precisely select a particular sequence from diverse partners. However, most signaling domains can bind to m
Externí odkaz:
https://doaj.org/article/7e4094522aaa4b2db064dd0b3e70c26a