Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Yu‐Chi Chou"'
Autor:
Xiaorui Chen, Arpita Mohapatra, Hong Thuy Vy Nguyen, Lisa Schimanski, Tiong Kit Tan, Pramila Rijal, Cheng-Pin Chen, Shu-Hsing Cheng, Wen-Hsin Lee, Yu-Chi Chou, Alain R Townsend, Che Ma, Kuan-Ying A Huang
Publikováno v:
PLoS Pathogens, Vol 20, Iss 6, p e1012246 (2024)
Antibody-mediated immunity plays a key role in protection against SARS-CoV-2. We characterized B-cell-derived anti-SARS-CoV-2 RBD antibody repertoires from vaccinated and infected individuals and elucidate the mechanism of action of broadly neutraliz
Externí odkaz:
https://doaj.org/article/6b2ca9b4f9fe4182828d175f566a58ee
Autor:
Li-Tzu Cheng, Grace Y. T. Tan, Fang-Pei Chang, Cheng-Kai Wang, Yu-Chi Chou, Pang-Hung Hsu, Wendy W. Hwang-Verslues
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract The intestinal epithelium is highly regenerative. Rapidly proliferating LGR5+ crypt base columnar (CBC) cells are responsible for epithelial turnover needed to maintain intestinal homeostasis. Upon tissue damage, loss of LGR5+ CBCs can be co
Externí odkaz:
https://doaj.org/article/b3e220562f2b488c8c642863d085ad16
Autor:
Yu-Tung Hsieh, Yi-Cheng Chen, Yu-Chi Chou, Pin‑Yu Kuo, Yi-Ting Yen, Hung-Wen Tsai, Chrong-Reen Wang
Publikováno v:
Journal of Biomedical Science, Vol 30, Iss 1, Pp 1-27 (2023)
Abstract Background Dysregulated long noncoding RNA (lncRNA) expression with increased apoptosis has been demonstrated in systemic lupus erythematosus (SLE) patients with alveolar hemorrhage (AH). SNHG16, a lncRNA, can enhance pulmonary inflammation
Externí odkaz:
https://doaj.org/article/636509c10ca94430909c532ea4281f48
Structural basis for a conserved neutralization epitope on the receptor-binding domain of SARS-CoV-2
Autor:
Kuan-Ying A. Huang, Xiaorui Chen, Arpita Mohapatra, Hong Thuy Vy Nguyen, Lisa Schimanski, Tiong Kit Tan, Pramila Rijal, Susan K. Vester, Rory A. Hills, Mark Howarth, Jennifer R. Keeffe, Alexander A. Cohen, Leesa M. Kakutani, Yi-Min Wu, Md Shahed-Al-Mahmud, Yu-Chi Chou, Pamela J. Bjorkman, Alain R. Townsend, Che Ma
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
An antibody, IY-2A, identified from a panel of class-4 SARS-CoV-2-neutralizing antibodies isolated from convalescent and vaccinated individuals, targets and induces partial unfolding of a conserved epitope within the RBD. IY-2A retains activity again
Externí odkaz:
https://doaj.org/article/4fd4ed3b1b214dcab49cfc9d3f96eda6
Autor:
Yu-Tung Hsieh, Yu-Chi Chou, Pin-Yu Kuo, Hung-Wen Tsai, Yi-Ting Yen, Ai-Li Shiau, Chrong-Reen Wang
Publikováno v:
Journal of Biomedical Science, Vol 29, Iss 1, Pp 1-20 (2022)
Abstract Background Increasing evidences have suggested an important role of microRNAs (miRNAs) in regulating cell death processes including NETosis and apoptosis. Dysregulated expression of miRNAs and increased formation of neutrophil extracellular
Externí odkaz:
https://doaj.org/article/babdda5bc276451696edc1a0386719a8
Autor:
Ruei-Min Lu, Kang-Hao Liang, Hsiao-Ling Chiang, Fu-Fei Hsu, Hsiu-Ting Lin, Wan-Yu Chen, Feng-Yi Ke, Monika Kumari, Yu-Chi Chou, Mi-Hua Tao, Yi-Ling Lin, Han-Chung Wu
Publikováno v:
Heliyon, Vol 9, Iss 5, Pp e15587- (2023)
The COVID-19 pandemic continues to threaten human health worldwide as new variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerge. Currently, the predominant circulating strains around the world are Omicron variants, which
Externí odkaz:
https://doaj.org/article/cf78b55bb0294b8882b03e15ebc72703
Autor:
I-Jung Lee, Cheng-Pu Sun, Ping-Yi Wu, Yu-Hua Lan, I-Hsuan Wang, Wen-Chun Liu, Joyce Pei-Yi Yuan, Yu-Wei Chang, Sheng-Che Tseng, Szu-I Tsung, Yu-Chi Chou, Monika Kumari, Yin-Shiou Lin, Hui-Feng Chen, Tsung-Yen Chen, Chih-Chao Lin, Chi-Wen Chiu, Chung-Hsuan Hsieh, Cheng-Ying Chuang, Chao-Min Cheng, Hsiu-Ting Lin, Wan-Yu Chen, Fu-Fei Hsu, Ming-Hsiang Hong, Chun-Che Liao, Chih-Shin Chang, Jian-Jong Liang, Hsiu-Hua Ma, Ming-Tsai Chiang, Hsin-Ni Liao, Hui-Ying Ko, Liang-Yu Chen, Yi-An Ko, Pei-Yu Yu, Tzu-Jing Yang, Po-Cheng Chiang, Shang-Te Hsu, Yi-Ling Lin, Chong-Chou Lee, Han-Chung Wu, Mi-Hua Tao
Publikováno v:
Journal of Biomedical Science, Vol 29, Iss 1, Pp 1-13 (2022)
Abstract Background With the continuous emergence of new SARS-CoV-2 variants that feature increased transmission and immune escape, there is an urgent demand for a better vaccine design that will provide broader neutralizing efficacy. Methods We repo
Externí odkaz:
https://doaj.org/article/f52cdfcd615b49699347c79554e26b54
Autor:
Kang-Hao Liang, Pao-Yin Chiang, Shih-Han Ko, Yu-Chi Chou, Ruei-Min Lu, Hsiu-Ting Lin, Wan-Yu Chen, Yi-Ling Lin, Mi-Hua Tao, Jia-Tsrong Jan, Han-Chung Wu
Publikováno v:
Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-12 (2021)
Abstract Background Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), an RNA virus with a high mutation rate. Importantly, several currently circulating SARS-CoV-2 variants are associated w
Externí odkaz:
https://doaj.org/article/7e765143995640ccb0b25900e804ab12
Autor:
Kuo-Hsuan Chang, Cheng-Yen Huang, Chih-Hsin Ou-Yang, Chang-Han Ho, Han-Yi Lin, Chia-Lang Hsu, You-Tzung Chen, Yu-Chi Chou, Yi-Jing Chen, Ying Chen, Jia-Li Lin, Ji-Kuan Wang, Pei-Wen Lin, Ying-Ru Lin, Miao-Hsia Lin, Chi-Kang Tseng, Chin-Hsien Lin
Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-18 (2021)
Abstract Background The c.G6055A (p.G2019S) mutation in leucine-rich repeat kinase 2 (LRRK2) is the most prevalent genetic cause of Parkinson’s disease (PD). CRISPR/Cas9-mediated genome editing by homology-directed repair (HDR) has been applied to
Externí odkaz:
https://doaj.org/article/bc881b164425452fba2c024c95eb8485
Autor:
Ling-Chih Chen, Yung-Lin Hsieh, Grace Y. T. Tan, Tai-Yun Kuo, Yu-Chi Chou, Pang-Hung Hsu, Wendy W. Hwang-Verslues
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Posttranslational modification (PTM) of core circadian clock proteins, including Period2 (PER2), is required for proper circadian regulation. PER2 function is regulated by casein kinase 1 (CK1)-mediated phosphorylation and ubiquitination but
Externí odkaz:
https://doaj.org/article/c8703bfb39e34a1f8846b341bee43c82