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pro vyhledávání: '"Ytik-Chor Wong"'
Publikováno v:
Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy ISBN: 9781489907400
The mechanisms of resistance to alkylating drugs include defective transport across the cell membrane, intracellular bio-transformation to inactivate the drug, and repair of damaged DNA (Goldenberg et al, 1979; Hilton, 1984; Vistica et al, 1978). Thu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00b1b33197947fa040a3cc9af174c2e8
https://doi.org/10.1007/978-1-4899-0738-7_30
https://doi.org/10.1007/978-1-4899-0738-7_30
Autor:
Stephen B. Howell
Taken together the data presented in this review, and work by many other investigators, support the notion that DNA excision repair is important in a tumor cell's resistance to platinum compounds. Inhibition of this repair system by combination chemo