Zobrazeno 1 - 10
of 601
pro vyhledávání: '"Yrjö T Konttinen"'
Autor:
Jaana T Joensuu, Saara Huoponen, Kalle J Aaltonen, Yrjö T Konttinen, Dan Nordström, Marja Blom
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0119683 (2015)
Background and objectivesEconomic evaluations provide information to aid the optimal utilization of limited healthcare resources. Costs of biologics for Rheumatoid arthritis (RA) are remarkably high, which makes these agents an important target for e
Externí odkaz:
https://doaj.org/article/2fa7973616084cb5bd77773ad62a875c
Autor:
Jukka Pajarinen, Tzu-Hua Lin, Taishi Sato, Florence Loi, Zhenyu Yao, Yrjö T Konttinen, Stuart B Goodman
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0142736 (2015)
Macrophages play a key role in tissue homeostasis as well as in a range of pathological conditions including atherosclerosis, cancer, and autoimmunity. Many aspects of their in vivo behavior are, however, poorly understood. Bioluminescence imaging (B
Externí odkaz:
https://doaj.org/article/ea7252daa06f4e61aee8b04b1383ed17
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0145279 (2015)
OBJECTIVE:Patients with rheumatoid arthritis (RA) have altered circadian rhythm of circulating serum cortisol, melatonin and IL-6, as well as disturbance in the expression of clock genes ARNTL2 and NPAS2. In humans, TNFα increases the expression ARN
Externí odkaz:
https://doaj.org/article/86c82f4666a343f9af26312cf139e64a
Autor:
Vesa-Petteri Kouri, Juri Olkkonen, Emilia Kaivosoja, Mari Ainola, Juuso Juhila, Iiris Hovatta, Yrjö T Konttinen, Jami Mandelin
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54049 (2013)
IntroductionPatients with rheumatoid arthritis (RA) have disturbances in the hypothalamic-pituitary-adrenal (HPA) axis. These are reflected in altered circadian rhythm of circulating serum cortisol, melatonin and IL-6 levels and in chronic fatigue. W
Externí odkaz:
https://doaj.org/article/6a82eb79d24f4cc980665e0d9b1e4821
Autor:
Kalle J Aaltonen, Liisa M Virkki, Antti Malmivaara, Yrjö T Konttinen, Dan C Nordström, Marja Blom
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e30275 (2012)
Background and objectivesFive-tumour necrosis factor (TNF)-blockers (infliximab, etanercept, adalimumab, certolizumab pegol and golimumab) are available for treatment of rheumatoid arthritis. Only few clinical trials compare one TNF-blocker to anothe
Externí odkaz:
https://doaj.org/article/b4c22d51390b49cba7d9ffc31379170a
Autor:
Yuya Takakubo, Yrjö T. Konttinen
Publikováno v:
Clinical and Developmental Immunology, Vol 2012 (2012)
Systemic autoimmune and rheumatic diseases (SAIRDs) are thought to develop due to the failure of autoimmune regulation and tolerance. Current therapies, such as biologics, have improved the clinical results of SAIRDs; however, they are not curative t
Externí odkaz:
https://doaj.org/article/857a50eb55b64817a11ec088b8ac2616
Autor:
Joana Caetano-Lopes, Ana Lopes, Ana Rodrigues, Diana Fernandes, Inês P Perpétuo, Teresa Monjardino, Raquel Lucas, Jacinto Monteiro, Yrjö T Konttinen, Helena Canhão, João E Fonseca
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e16947 (2011)
BACKGROUND: Fracture healing is orchestrated by a specific set of events that culminates in the repair of bone and reachievement of its biomechanical properties. The aim of our work was to study the sequence of gene expression events involved in infl
Externí odkaz:
https://doaj.org/article/06d2a5b27fc845209034717a0c61047b
Autor:
Yuya Takakubo, Yrjö T. Konttinen, Christophe Nich, Stuart B. Goodman, Jiri Gallo, Michiaki Takagi, Jukka Pajarinen
Publikováno v:
Journal of Long-Term Effects of Medical Implants. 26:303-309
Normal usage of total joint replacements results in the production of wear debris and other byproducts. In particular, polyethylene particles are heavily involved in the stimulation of local and systemic biological reactions resulting in chronic infl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::137b86089703514c2fb40675aa48fbee
https://doi.org/10.1615/jlongtermeffmedimplants.2017011287
https://doi.org/10.1615/jlongtermeffmedimplants.2017011287
Autor:
Paul L. Chazot, Yan Chen, Jere Paavola, Vasili Stegajev, Yrjö T. Konttinen, Holger Stark, Jianguo Wen
Publikováno v:
European Journal of Pharmacology. 754:173-178
Histamine is a neurotransmitter and chemical mediator in multiple physiological processes. Histamine H3 receptor is expressed in the nervous system, heart, and gastrointestinal tract; however, little is known about H3 receptor in skeletal muscle. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c7fbec5f6791caec2d572a54b698ccb
https://doi.org/10.1016/j.ejphar.2015.02.035
https://doi.org/10.1016/j.ejphar.2015.02.035
Autor:
Yrjö T. Konttinen, J. Joensuu, Tea Uusitalo, Vappu Rantalaiho, Kari Puolakka, Laura Pirilä, Tuulikki Sokka, Marja Blom, Dan Nordström, Heikki Valleala, Pasi Aronen, Kalle Aaltonen, Liisa Virkki, Heikki Relas
Publikováno v:
The Journal of Rheumatology. 42:372-378
Objective.Because of the role of tumor necrosis factor (TNF) in host defense, it was hypothesized that its inhibition might lead to an increased risk of malignancies and infections. The objective of our study was to assess the incidence of serious in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4fd0d95ba9c7f9c0aa7b1352f2c20b0
https://doi.org/10.3899/jrheum.140853
https://doi.org/10.3899/jrheum.140853