Multi-target gene therapy AUP1602-C to improve healing and quality of life for diabetic foot ulcer patients: a phase I, open-label, dose-finding study.

Autor: Schindler, Christoph, Mikosiński, Jacek, Mikosiński, Pawel, Kärkkäinen, Hanna-Riikka, Sanio, Mirka, Kurkipuro, Jere, Mierau, Igor, Smith, Wesley, Vartiainen, Aki, Décory, Laurent, Weber, Dirk, Wirth, Thomas, Yrjänheikki, Juha, Schellong, Sebastian, Samaranayake, Haritha

Publikováno v: Therapeutic Advances in Endocrinology & Metabolism; 11/4/2024, p1-25, 25p

Spreading Depression and Focal Brain Ischemia Induce Cyclooxygenase-2 in Cortical Neurons through N-methyl-D-aspartic Acid-Receptors and Phospholipase A2

Autor: Miettinen, Susanna, Fusco, Francesca R., Yrjänheikki, Juha, Keinänen, Riitta, Hirvonen, Timo, Roivainen, Reina, Närhi, Matti, Hökfelt, Tomas, Koistinaho, Jari

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 1997 Jun 01. 94(12), 6500-6505.

Externí odkaz: https://www.jstor.org/stable/42387

β-Amyloid Infusion Results in Delayed and Age-Dependent Learning Deficits without Role of Inflammation or β-Amyloid Deposits

Autor: Malm, Tarja, Ort, Michael, Tähtivaara, Leena, Jukarainen, Niko, Goldsteins, Gundars, Puoliväli, Jukka, Nurmi, Antti, Pussinen, Raimo, Ahtoniemi, Toni, Miettinen, Taina-Kaisa, Kanninen, Katja, Leskinen, Suvi, Vartiainen, Nina, Yrjänheikki, Juha, Laatikainen, Reino, Harris-White, Marni E., Koistinaho, Milla, Frautschy, Sally A., Bures, Jan, Koistinaho, Jari

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 2006 Jun 01. 103(23), 8852-8857.

Externí odkaz: https://www.jstor.org/stable/30050278

OP148 4-IN-1 LIVE BIOTHERAPEUTIC GENE THERAPY MEDICINAL PRODUCT (GTMP) ACCELERATES HEALING OF DIABETIC FOOT ULCERS (DFU): A FIRST-IN-HUMAN, PHASE-1 CLINICAL STUDY.

Autor: Schindler, Christoph, Mikosiński, Jacek, Shellong, Sebastian, Samaranayake, Haritha, Kärkkäinen, Hanna-Riikka, Tikkanen, Mirka, Kurkipuro, Jere, Mierau, Igor, Smith, Wesley, Décory, Laurent, Weber, Dirk, Wirth, Thomas, Yrjänheikki, Juha

Publikováno v: Journal of Wound Management; Jul2023, Vol. 24 Issue 2, p471-471, 1/2p

Interleukin-1 beta-induced expression of the prostaglandin E-receptor subtype EP3 in U373 astrocytoma cells depends on protein kinase C and nuclear factor-kappaB

Autor: Waschbisch, Anne, Fiebich, Bernd L, Akundi, Ravi Shankar, Schmitz, M Lienhard, Hoozemans, Jeroen J M, Candelario-Jalil, Eduardo, Virtainen, Nina, Veerhuis, Robert, Slawik, Helen, Yrjänheikki, Juha, Hüll, Michael

Publikováno v: Waschbisch, A, Fiebich, B L, Akundi, R S, Schmitz, M L, Hoozemans, J J M, Candelario-Jalil, E, Virtainen, N, Veerhuis, R, Slawik, H, Yrjänheikki, J & Hüll, M 2006, ' Interleukin-1 beta-induced expression of the prostaglandin E-receptor subtype EP3 in U373 astrocytoma cells depends on protein kinase C and nuclear factor-kappaB ', Journal of Neurochemistry, vol. 96, no. 3, pp. 680-93 . https://doi.org/10.1111/j.1471-4159.2005.03599.x
Journal of Neurochemistry, 96(3), 680-93. Wiley-Blackwell

Both interleukin-1beta (IL-1beta) and prostaglandins (PGs) are important mediators of physiological and pathophysiological processes in the brain. PGE2 exerts its effects by binding to four different types of PGE2 receptors named EP1-EP4. EP3 has fou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::971599d1be3cf358f2f17f9cb0b5f977
https://research.vumc.nl/en/publications/aefdfdeb-41ba-4359-a94d-96bbd96ba897