Lapcin, a potent dual topoisomerase I/II inhibitor discovered by soil metagenome guided total chemical synthesis

Autor: Zongqiang Wang, Nicholas Forelli, Yozen Hernandez, Melinda Ternei, Sean F. Brady

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)

Chemical synthesis of secondary metabolites isolated from nature, and derivatives thereof, is still a paradigm of significance to drug development. Here the authors instead use bioinformatics to analyze a biosynthetic gene cluster found in the soil m

Externí odkaz: https://doaj.org/article/907f3ef3a9824f6891e0f4fae08900a7

Identification of structurally diverse menaquinone-binding antibiotics with in vivo activity against multidrug-resistant pathogens

Autor: Lei Li, Bimal Koirala, Yozen Hernandez, Logan W. MacIntyre, Melinda A. Ternei, Riccardo Russo, Sean F. Brady

Publikováno v: Nature Microbiology. 7:120-131

The emergence of multidrug-resistant bacteria poses a threat to global health and necessitates the development of additional in vivo active antibiotics with diverse modes of action. Directly targeting menaquinone (MK), which plays an important role i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2aca9521bd6665f8b1a5d8fbd7ed351
https://doi.org/10.1038/s41564-021-01013-8

Biosynthetic Interrogation of Soil Metagenomes Reveals Metamarin, an Uncommon Cyclomarin Congener with Activity against Mycobacterium tuberculosis

Autor: Lei Li, Riccardo Russo, Bimal Koirala, Thahmina Ali, Yozen Hernandez, Logan W MacIntyre, Sean F. Brady

Publikováno v: Journal of Natural Products

Tuberculosis (TB) remains one of the deadliest infectious diseases. Unfortunately, the development of antibiotic resistance threatens our current therapeutic arsenal, which has necessitated the discovery and development of novel antibiotics against d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66f41646b74dc889dde6e9b3c7aec94b
http://europepmc.org/articles/PMC8068612

A naturally inspired antibiotic to target multi-drug-resistant pathogens

Autor: Zongqiang Wang, Bimal Koirala, Yozen Hernandez, Matthew Zimmerman, Steven Park, David S. Perlin, Sean F. Brady

Publikováno v: Nature

Gram-negative bacteria are responsible for an increasing number of deaths from antibiotic resistant infections.(1,2) The bacterial natural product, colistin, is considered the last line of defense against a number of Gram-negative pathogens. The rece

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ff565377ec3f04a5f5170e6dd7cd1bb
https://europepmc.org/articles/PMC10321319/

BpWrapper: BioPerl-based sequence and tree utilities for rapid prototyping of bioinformatics pipelines

Autor: Saymon Akther, Filipe G. Vieira, Amanda Larracuente, Wei-Gang Qiu, Yozen Hernandez, Girish Ramrattan, Levy C. Vargas, Lia Di, Pedro E. Pagan, Rocky Bernstein, William D. McCaig

Publikováno v: BMC Bioinformatics
Hernandez, Y, Bernstein, R, Pagan, P, Vargas, L, McCaig, W, Ramrattan, G, Akther, S, Larracuente, A, Di, L, Vieira, F J G & Qiu, W-G 2018, ' BpWrapper : BioPerl-based sequence and tree utilities for rapid prototyping of bioinformatics pipelines ', B M C Bioinformatics, vol. 19, 76 . https://doi.org/10.1186/s12859-018-2074-9
BMC Bioinformatics, Vol 19, Iss 1, Pp 1-7 (2018)

Background Automated bioinformatics workflows are more robust, easier to maintain, and results more reproducible when built with command-line utilities than with custom-coded scripts. Command-line utilities further benefit by relieving bioinformatics

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0998ffaf0d9be75dd1be608417eafc7
http://europepmc.org/articles/PMC5833151