Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Youzhi Tong"'
Publikováno v:
Materials Research Express, Vol 9, Iss 3, p 036502 (2022)
The effect of width on the surface quenching residual stress distribution in 7055 aluminium alloy plates of different width values was studied. The distribution of quenching residual stresses of the plates were studied by both simulation and experime
Externí odkaz:
https://doaj.org/article/cd910a1e68244b96a28c52936278cb29
Publikováno v:
Acta Crystallographica Section F Structural Biology Communications. 79:95-104
Mutations in the androgen receptor (AR) ligand-binding domain (LBD) can cause resistance to drugs used to treat prostate cancer. Commonly found mutations include L702H, W742C, H875Y, F877L and T878A, while the F877L mutation can convert second-genera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::911bd972c65512667604b8f2e6ff7a1c
https://doi.org/10.1107/s2053230x23002224
https://doi.org/10.1107/s2053230x23002224
Autor:
Hanfang Jiang, Quchang Ouyang, Yongmei Yin, Zhongshen Tong, Kunwei Shen, Zhongyu Yuan, Cuizhi Geng, Yaxin Liu, Guohong Song, Ran Ran, Wei Li, Qing Qu, Meiyu Wang, Luping Meng, Youzhi Tong, Huiping Li
Publikováno v:
European Journal of Cancer. 176:1-12
Proxalutamide is a novel second-generation non-steroidal androgen receptor (AR) antagonist. This study aimed to evaluate the preliminary efficacy and safety of proxalutamide in patients with AR-positive metastatic breast cancer (ARIn this open-label,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1900ba2c1636f617638fa1ad00ecc84
https://doi.org/10.1016/j.ejca.2022.08.025
https://doi.org/10.1016/j.ejca.2022.08.025
Autor:
Guohong Song, Jiayang Zhang, Qingqing Zhou, Honghua Yan, Ye Sun, Meiyu Wang, Ruyan Zhang, Qiaoxia Zhou, Hanfang Jiang, Huiping Li, Youzhi Tong, Yaxin Liu, Qianxiang Zhou, Xunwei Dong, Liandong Ma, Ran Ran, Luping Meng
Publikováno v:
Breast Cancer Research and Treatment
Purpose To evaluate GT0918, a 2nd-generation AR antagonist, for its AR down-regulation activity among breast cancer patients. Methods The effect of GT0918 on AR protein expression was evaluated in AR expression breast cancer cells and in breast cance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0734a95a893deb17b41da014bad79e47
https://doi.org/10.1007/s10549-021-06345-x
https://doi.org/10.1007/s10549-021-06345-x
Autor:
Liandong Ma, Qianxiang Zhou, Honghua Yan, Min Dong, Xiahe Han, Jiangwie Li, Jie Qu, Weidong Qian, Youzhi Tong
Publikováno v:
Cancer Research. 83:4978-4978
Acute Myeloid Leukemia (AML) is the third hematological malignancies with the worst relative overall 5-year survival rate (11.7%) in hematological malignancies. AML is a heterogeneous disease with a broad spectrum of genomic changes and molecular mut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::341d677ed52449864eecb7cfcac30c8a
https://doi.org/10.1158/1538-7445.am2023-4978
https://doi.org/10.1158/1538-7445.am2023-4978
Autor:
Xiaodan Hou, Honghua Yan, Ao Wang, Cong Liu, Qianxiang Zhou, Liandong Ma, Jie Chen, Zhihua Ren, Youzhi Tong
Coronavirus disease 2019 (COVID-19) has caused the public health crisis in the whole world. Anti-androgens block severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) entry and protect against severe clinical COVID-19 outcomes. GT0918, a novel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::434c17115f09d462bd0a127e204acd64
https://doi.org/10.1101/2022.06.29.498191
https://doi.org/10.1101/2022.06.29.498191
Autor:
Yongan Zhang, Youzhi Tong, Baiqing Xiong, Yan Hongwei, Hongwei Liu, Kai Wen, Ya-Nan Li, Zhihui Li, Lizhen Yan, Xiwu Li, Weicai Ren
Publikováno v:
Scripta Materialia. 186:259-262
Secondary cracks were frequently reported in fatigue failure of aviation aluminum alloy. In present study, scanning electron microscope observation of fracture morphology was carried out on an Al-Zn-Mg-Cu alloy extrusion plate with high zinc content.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2336c8b9be0be99728fa4074e4db70fd
https://doi.org/10.1016/j.scriptamat.2020.05.045
https://doi.org/10.1016/j.scriptamat.2020.05.045
Autor:
Ruyan Zhang, Huiping Li, Ran Ran, Qiaoxia Zhou, Luping Meng, Hanfang Jiang, Guohong Song, Youzhi Tong, Ke Chen, Phoebe Zhang, Yaxin Liu, Karl Zhou
Publikováno v:
Cancer Research. 80:P2-17
Background: Androgen receptor (AR) blocker has become an increased interest in the treatment of BC, in which about 60-80% patients showed AR positive. However, currently no AR blocker has been approved in mBC. GT0918 is a new chemical entity of AR bl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a1b5e26829524e3561d6147b3c3606b
https://doi.org/10.1158/1538-7445.sabcs19-p2-17-05
https://doi.org/10.1158/1538-7445.sabcs19-p2-17-05
Autor:
Liandong Ma, Youzhi Tong, Zhaohui Yang, Qianxiang Zhou, Hongha Yan, Ru Xu, Jie Chen, Jie Pan, Huiyuan Wang, Jiangwei Li, Dong Chen, Xiang Cai, Jie Qu, Yini Wang, Jun Qin, Yuki Nishida, Michael Andreeff, Qilnli Guo
Publikováno v:
Cancer Research. 82:5479-5479
c-Myc is an oncogenic transcriptional factor driving tumor initiation, progression and poor prognosis in 80% of all tumor types, especially in B-cell malignancies and small cell lung cancer (SCLC) with Myc genomic alterations. Myc dysregulation have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57e311ff6a59a38f26519ff5b3f71eb6
https://doi.org/10.1158/1538-7445.am2022-5479
https://doi.org/10.1158/1538-7445.am2022-5479
Autor:
Liandong Ma, Youzhi Tong, Qianxiang Zhou, Hongha Yan, Xiaodan Hou, Zhiha Ren, Jiangwei Li, Huiyuan Wang, Weidong Qian, Yu Zhang, Andy Goren, Arul Chinnaiyan
Publikováno v:
Cancer Research. 82:5274-5274
As of November 2021, there were 21 million confirmed active cases of COVID-19, including 77,016 patients in serious or critical condition (virusncov.com). However, there are no effective oral drugs for the treatment of severe COVID 19 patients. We he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a9ab69be38b4987f0b6d59c88287fe8
https://doi.org/10.1158/1538-7445.am2022-5274
https://doi.org/10.1158/1538-7445.am2022-5274