Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Youxin Guan"'
Autor:
Peiyan Ni, Haneul Noh, Zhicheng Shao, Qian Zhu, Youxin Guan, Joshua J. Park, Fatima Arif, James M. Park, Chiderah Abani, Cameron Beaudreault, Joy S. Park, Elizabeth Berry, Alexander Moghadam, Patric Stanton, John N. Hutchinson, Bill Andrews, Clare Faux, John Parnevelas, Leonard M. Eisenberg, Kyungjoon Park, Vadim Y. Bolshakov, Sangmi Chung
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 13, Iss , Pp 414-430 (2019)
During development, cortical interneurons (cINs) are generated from the ventral telencephalon, robustly migrate to the dorsal telencephalon, make local synaptic connections, and critically regulate brain circuitry by inhibiting other neurons. Thus, t
Externí odkaz:
https://doaj.org/article/66ad75cbb92c4f76b4426804c1f0cfa2
Autor:
Amanda R. Moore, Leili Ran, Youxin Guan, Jessica J. Sher, Tyler D. Hitchman, Jenny Q. Zhang, Catalina Hwang, Edward G. Walzak, Alexander N. Shoushtari, Sébastien Monette, Rajmohan Murali, Thomas Wiesner, Klaus G. Griewank, Ping Chi, Yu Chen
Publikováno v:
Cell Reports, Vol 22, Iss 9, Pp 2455-2468 (2018)
Summary: Uveal melanoma (UM) is characterized by mutually exclusive activating mutations in GNAQ, GNA11, CYSLTR2, and PLCB4, four genes in a linear pathway to activation of PLCβ in almost all tumors and loss of BAP1 in the aggressive subset. We gene
Externí odkaz:
https://doaj.org/article/f955f766b62846e19190082e6000d91d
Autor:
Dong Gao, Yu Zhan, Wei Di, Amanda R Moore, Jessica J Sher, Youxin Guan, Shangqian Wang, Zeda Zhang, Devan A Murphy, Charles L Sawyers, Ping Chi, Yu Chen
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0161084 (2016)
Fusion between TMPRSS2 and ERG, placing ERG under the control of the TMPRSS2 promoter, is the most frequent genetic alteration in prostate cancer, present in 40-50% of cases. The fusion event is an early, if not initiating, event in prostate cancer,
Externí odkaz:
https://doaj.org/article/c7848b1536d844d4976f31c6711bd4ab
Autor:
Ping Chi, Yu Chen, Cristina R. Antonescu, Richard P. Koche, Deyou Zheng, Yuanyuan Xie, Alan Chramiec, Katie Yang Li, Shipra Shukla, Youxin Guan, Shangqian Wang, Zhen Cao, Inna Sirota, Kemal Deniz, Dan Li, Jenny Q. Zhang, Devan Murphy, Elissa W.P. Wong, Jessica Sher, Yuedan Chen, Leili Ran
Figure S1. Expression of forkhead family transcription factors in GIST; S2. Motif analysis of the FOXF1 cistrome and validation of FOXF1 binding sites in GIST 48 cells; S3. FOXF1 regulates ETV1, KIT, and ETV1- and KIT-dependent transcriptome as well
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bc08cd7300f2658298ce2882eeed127
https://doi.org/10.1158/2159-8290.22532126.v1
https://doi.org/10.1158/2159-8290.22532126.v1
Autor:
Ping Chi, Yu Chen, Cristina R. Antonescu, Richard P. Koche, Deyou Zheng, Yuanyuan Xie, Alan Chramiec, Katie Yang Li, Shipra Shukla, Youxin Guan, Shangqian Wang, Zhen Cao, Inna Sirota, Kemal Deniz, Dan Li, Jenny Q. Zhang, Devan Murphy, Elissa W.P. Wong, Jessica Sher, Yuedan Chen, Leili Ran
S1. De novo motifs in GIST-Specific ETV1 enhancers; S2. De novo motifs in Prostate Specific ETV1 enhancers; S3. De novo motifs in Shared ETV1 enhancers; S4. De novo motifs in Shared ETV1 promoters; S5: Expression of Forkhead Transcription Factors in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81a9dd2b1a8646d955f5eaeb2060bc78
https://doi.org/10.1158/2159-8290.22532123
https://doi.org/10.1158/2159-8290.22532123
Autor:
Ping Chi, Yu Chen, Cristina R. Antonescu, Yu Zhan, Shipra Shukla, Yuanyuan Xie, Youxin Guan, Edward Walczak, Shangqian Wang, Zhen Cao, Jessica Sher, Devan Murphy, Leili Ran
Combination of homozygous BrafV600E activation and Trp53 loss induced dramatic ICC hyperplasia in stomach, cecum and large intestine, but not in small intestine.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::962302b697923be0ddd4edc24434d8e9
https://doi.org/10.1158/0008-5472.22414659
https://doi.org/10.1158/0008-5472.22414659
Autor:
Ping Chi, Yu Chen, Cristina R. Antonescu, Yu Zhan, Shipra Shukla, Yuanyuan Xie, Youxin Guan, Edward Walczak, Shangqian Wang, Zhen Cao, Jessica Sher, Devan Murphy, Leili Ran
Gastrointestinal stromal tumor (GIST) is the most common subtype of sarcoma. Despite clinical advances in the treatment of KIT/PDGFRA–mutant GIST, similar progress against KIT/PDGFRA wild-type GIST, including mutant BRAF-driven tumors, has been lim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11a7e5ca44f5894be551497f0aa5d915
https://doi.org/10.1158/0008-5472.c.6509046.v1
https://doi.org/10.1158/0008-5472.c.6509046.v1
Autor:
Yu Chen, Ping Chi, Thomas Huber, Thomas P. Sakmar, Barry S. Taylor, Matthew T. Chang, Juliet Chen, Youxin Guan, Jasmine H. Francis, Alexander N. Shoushtari, Mohini R. Pachai, Naitao Wang, Ruobing Jia, Cindy Lee, Amanda R. Moore, Emilie Ceraudo, Gabriella Bayshtok, Tyler D. Hitchman
Purpose:All uveal melanoma and a fraction of other melanoma subtypes are driven by activation of the G-protein alpha-q (Gαq) pathway. Targeting these melanomas has proven difficult despite advances in the molecular understanding of key driver signal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5081a528234de947ebc82cb311f8ab41
https://doi.org/10.1158/1078-0432.c.6530301
https://doi.org/10.1158/1078-0432.c.6530301
Autor:
Yu Chen, Ping Chi, Thomas Huber, Thomas P. Sakmar, Barry S. Taylor, Matthew T. Chang, Juliet Chen, Youxin Guan, Jasmine H. Francis, Alexander N. Shoushtari, Mohini R. Pachai, Naitao Wang, Ruobing Jia, Cindy Lee, Amanda R. Moore, Emilie Ceraudo, Gabriella Bayshtok, Tyler D. Hitchman
Supplementary figures S1-S6 with figure legends.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ce8efd4e6384fb453406751fddbe584
https://doi.org/10.1158/1078-0432.22479795.v1
https://doi.org/10.1158/1078-0432.22479795.v1
Autor:
Yu Chen, Ping Chi, Thomas Huber, Thomas P. Sakmar, Barry S. Taylor, Matthew T. Chang, Juliet Chen, Youxin Guan, Jasmine H. Francis, Alexander N. Shoushtari, Mohini R. Pachai, Naitao Wang, Ruobing Jia, Cindy Lee, Amanda R. Moore, Emilie Ceraudo, Gabriella Bayshtok, Tyler D. Hitchman
raw uncropped labeled western blots
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3664900e14a101e3af47e3c9420a7341
https://doi.org/10.1158/1078-0432.22479798
https://doi.org/10.1158/1078-0432.22479798