Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Youxi Ai"'
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e114472 (2014)
Intracerebral hemorrhage is a subset of stroke for which there is no specific treatment. The Ly6Chi CCR2+ monocytes have been shown to contribute to acute injury after intracerebral hemorrhage. The other murine monocyte subset expresses CX3CR1 and lo
Externí odkaz:
https://doaj.org/article/af60b3c14c2f4c85ab2ee70acc2e4316
Autor:
Joseph T. Caulfield, Sushmita Mukherjee, Robert J. Hondal, Botir T. Sagdullaev, Ishraq Alim, Rajiv R. Ratan, Yingxin Chen, Emma J. Ste.Marie, Elena Ivanova, Daniel H. Geschwind, Vivek Swarup, Lauren H Sansing, Saravanan S. Karuppagounder, Javier Seravalli, John W. Cave, Youxi Ai
Publikováno v:
Cell. 177(5)
Ferroptosis, a non-apoptotic form of programmed cell death, is triggered by oxidative stress in cancer, heat stress in plants, and hemorrhagic stroke. A homeostatic transcriptional response to ferroptotic stimuli is unknown. We show that neurons resp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f3313a6690b6f793e2345b1faebf41b
https://pubmed.ncbi.nlm.nih.gov/31056284
https://pubmed.ncbi.nlm.nih.gov/31056284
Autor:
David M. Greer, Hannah E. Beatty, Che-Feng Chang, Matthias Mack, Arthur F. Steinschneider, Fahmeed Hyder, Anita Huttner, Matthew D. Hammond, Sourav Ghosh, Kevin N. Sheth, Brittany A. Goods, Luís Henrique Angenendt da Costa, Lauren H Sansing, J. Christopher Love, Margaret J. Landreneau, Carla V. Rothlin, Michael H. Askenase, Daniel Coman, Stephen C. Renfroe, Youxi Ai
Macrophages are a source of both proinflammatory and restorative functions in damaged tissue through complex dynamic phenotypic changes. Here, we sought to determine whether monocyte-derived macrophages (MDMs) contribute to recovery after acute steri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c29eb5466197ffce69721238f88f0e7
https://europepmc.org/articles/PMC5785262/
https://europepmc.org/articles/PMC5785262/
Autor:
Youxi Ai, Roslyn A Taylor, Carla V. Rothlin, Che-Feng Chang, Brittany A. Thomas, Michael H. Askenase, Arthur F. Steinschneider, Christopher J. Love, Lauren H Sansing
Publikováno v:
Stroke. 48
Introduction: Local inflammation contributes to both brain injury and recovery after intracerebral hemorrhage (ICH). Our previous studies have shown brain-infiltrating macrophages (BIMs) aggravate early brain injury after ICH; however, BIMs increase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec42f6764f8b7cf78a8ab6f2b1b64af4
https://doi.org/10.1161/str.48.suppl_1.tp351
https://doi.org/10.1161/str.48.suppl_1.tp351
Publikováno v:
Stroke. 48
Introduction: After intracerebral hemorrhage (ICH), erythrocytes contribute to secondary injury by releasing toxic hemoproteins. Our lab has previously shown that blood derived macrophages play an important role in ICH clearance but mechanisms of pha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a5732c822597b69c0b6db3b34ad123b
https://doi.org/10.1161/str.48.suppl_1.wmp105
https://doi.org/10.1161/str.48.suppl_1.wmp105
Autor:
Lauren H Sansing, David A. Hafler, J. Christopher Love, Louise D. McCullough, Brittany A. Goods, Roslyn A Taylor, Michael H. Askenase, Arthur F. Steinschneider, Youxi Ai, Scott E. Kasner, Michael T. Mullen, Matthew D. Hammond, Stephen C. Renfroe, Che-Feng Chang, Brian Mac Grory
Publikováno v:
The Journal of clinical investigation. 127(1)
Intracerebral hemorrhage (ICH) is a devastating form of stroke that results from the rupture of a blood vessel in the brain, leading to a mass of blood within the brain parenchyma. The injury causes a rapid inflammatory reaction that includes activat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc9ce1353a9982927ef431fb08ec12e2
https://pubmed.ncbi.nlm.nih.gov/27893460
https://pubmed.ncbi.nlm.nih.gov/27893460
Publikováno v:
Stroke. 47
Introduction: Inflammation contributes to both injury and recovery after intracerebral hemorrhage (ICH). Our previous studies showed that blood-derived CCR2 + monocytes/macrophages infiltration induces brain injury in acute ICH, whereas these cells a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1f64c9acc2a3c342c6361ef2eade308
https://doi.org/10.1161/str.47.suppl_1.tp257
https://doi.org/10.1161/str.47.suppl_1.tp257
Publikováno v:
Translational Stroke Research. 3:125-131
Intracerebral hemorrhage (ICH) is a devastating disease lacking an effective treatment. While the initial injury occurs within minutes, an inflammatory response contributes to ongoing tissue damage over hours to days. Relatively little is known about
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e54acaf5e251548dccd87b0f9a9f956d
https://doi.org/10.1007/s12975-012-0174-9
https://doi.org/10.1007/s12975-012-0174-9
Autor:
Youxi Ai, Ming-Tao Wu, Ari Ristimäki, Timothy Hla, Hector L. Aguila, Caiying Guo, Mallika Ghosh, Jason Michaud, Henry Furneaux, Annabrita Hemmes
Publikováno v:
Journal of Clinical Investigation. 119:3530-3543
The RNA-binding protein HuR (also known as ELAV1) binds to the 3′-untranslated region of mRNAs and regulates transcript stability and translation. However, the in vivo functions of HuR are not well understood. Here, we report that murine HuR is ess
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::837f1592432c5e699d2c8d9e6292ffba
https://doi.org/10.1172/jci38263
https://doi.org/10.1172/jci38263
Publikováno v:
Prostaglandins & Other Lipid Mediators. 88:97-100
Cyclooxygenase-2 (COX-2), overexpressed in inflammatory conditions and cancer, regulates angiogenesis and tumorigenesis via the production of biologically active prostanoids. Previously, we showed that COX-2 over-expression in the mammary gland of tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc93391c1f7d691ae314155881727ca4
https://doi.org/10.1016/j.prostaglandins.2008.11.004
https://doi.org/10.1016/j.prostaglandins.2008.11.004