Single-mitochondrion sequencing uncovers distinct mutational patterns and heteroplasmy landscape in mouse astrocytes and neurons

Autor: Parnika S. Kadam, Zijian Yang, Youtao Lu, Hua Zhu, Yasemin Atiyas, Nishal Shah, Stephen Fisher, Erik Nordgren, Junhyong Kim, David Issadore, James Eberwine

Publikováno v: BMC Biology, Vol 22, Iss 1, Pp 1-24 (2024)

Abstract Background Mitochondrial (mt) heteroplasmy can cause adverse biological consequences when deleterious mtDNA mutations accumulate disrupting “normal” mt-driven processes and cellular functions. To investigate the heteroplasmy of such mtDN

Externí odkaz: https://doaj.org/article/b5f7b29c50464504aa8a0218d124557b

HRS mediates tumor immune evasion by regulating proteostasis-associated interferon pathway activation

Autor: Wei Zhang, Jiegang Yang, Beike Wang, Youtao Lu, Jingbo Yang, Wenqun Zhong, Ziyan Yu, Zhiyuan Qin, Bolin Xiao, Kuiming Wang, Yi Y. Ma, Ravi Amaravadi, Meenhard Herlyn, Junhyong Kim, Xiaowei Xu, Wei Guo

Publikováno v: Cell Reports, Vol 42, Iss 11, Pp 113352- (2023)

Summary: By sorting receptor tyrosine kinases into endolysosomes, the endosomal sorting complexes required for transport (ESCRTs) are thought to attenuate oncogenic signaling in tumor cells. Paradoxically, ESCRT members are upregulated in tumors. Her

Externí odkaz: https://doaj.org/article/9ebb2925074d4fe69ec30225145dad72

Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response

Autor: Liyun Dong, Qiwen Man, Beike Wang, Gordon B. Mills, Gao Zhang, Tara C. Mitchell, Hou-Fu Xia, Xiaoming Liu, Wenqun Zhong, Bin Wu, Leonardo F. Antelo, Wei Guo, Rajasekharan Somasundaram, Ting Li, Giorgos C. Karakousis, Wei Zhang, Meenhard Herlyn, Yi-Fang Zhao, Jiegang Yang, Ravi Radhakrishnan, Wei Xu, Yiling Lu, Alexander C. Huang, Suzanne McGettigan, Wu Min, Honghong Sun, Junhyong Kim, Lynn M. Schuchter, Xuepeng Xiong, Youhai H. Chen, E. John Wherry, Ruifeng Yang, Chen Gang, Lei Guan, Xiaowei Xu, Haidong Dong, Youtao Lu, Shujing Liu, Zi-Li Yu

Publikováno v: Nature

Tumour cells evade immune surveillance by upregulating the surface expression of programmed death-ligand 1 (PD-L1), which interacts with programmed death-1 (PD-1) receptor on T cells to elicit the immune checkpoint response1,2. Anti-PD-1 antibodies h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a5b36179fc41e3220daf47bc8fa98dc
https://doi.org/10.1038/s41586-018-0392-8

Homophone auditory processing in cross-linguistic perspective

Autor: James L. Morgan, Youtao Lu

Publikováno v: Proceedings of the Linguistic Society of America. 5:529

Previous studies reported conflicting results for the effects of homophony on visual word processing across languages. On finding significant differences in homophone density in Japanese, Mandarin Chinese and English, we conducted two experiments to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e07d7d5ab40adcc002cd548bb601e2b8
https://doi.org/10.3765/plsa.v5i1.4733

Dissection of the module network implementation 'LemonTree': enhancements towards applications in metagenomics and translation in autoimmune maladies

Autor: Christine Nardini, Youtao Lu, Xiaoyuan Zhou

Publikováno v: Molecular bioSystems
13 (2017): 2083–2091. doi:10.1039/c7mb00248c
info:cnr-pdr/source/autori:Lu Y.; Zhou X.; Nardini C./titolo:Dissection of the module network implementation "lemonTree": Enhancements towards applications in metagenomics and translation in autoimmune maladies/doi:10.1039%2Fc7mb00248c/rivista:Molecular bioSystems (Print)/anno:2017/pagina_da:2083/pagina_a:2091/intervallo_pagine:2083–2091/volume:13

Under the current deluge of omics, module networks distinctively emerge as methods capable of not only identifying inherently coherent groups (modules), thus reducing dimensionality, but also hypothesizing cause–effect relationships between modules

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::676822aa11b43aeac03a57fc0aee3b8f
https://pubmed.ncbi.nlm.nih.gov/28809429