Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Yousuke Ebina"'
Autor:
Seiichi Hashida, Shuhei Ishikura, Yousuke Ebina, Keiji Uchiyama, Hisao Nagaya, Tomoyuki Yuasa, Kikuko Amo
Publikováno v:
Biochemical and Biophysical Research Communications. 445:236-243
Soluble insulin receptor (sIR), the ectodomain of IR, has been detected in human plasma, and its concentration parallels that of blood glucose in patients with diabetes. IR has a pivotal role in glucose homeostasis and diabetes development; therefore
Autor:
Asako Umehara, Hiroshi Shiota, Seiichi Hashida, Toshiyuki Obata, Yousuke Ebina, Mamiko Nishioka
Publikováno v:
Clinical Biochemistry. 42:1468-1475
Objective For the early identification of patients at risk of developing diabetes mellitus, and to prevent the onset of diabetes by performing dietary counseling and exercise guidance, we have developed an ultra-sensitive immune complex transfer enzy
Autor:
Toshiyuki Obata, Tomoyuki Yuasa, Yousuke Ebina, Hiroyuki Sano, Keiji Uchiyama, Kazushiro Kishi, Kiyoshi Teshigawara, Yoshinori Tanaka, Toshio Hosaka, Yuko Ogura, Masafumi Kimura
Publikováno v:
Endocrine Journal. 56:345-359
Akt substrate of 160kDa (AS160) is a Rab GTPase activating protein (GAP) and was recently identified as a component of the insulin signaling pathway of glucose transporter type 4 (GLUT4) translocation. We and others, previously reported that the acti
Autor:
Hossein Nazari, Kazuaki Mawatari, Nagakatsu Harada, Kazuhiro Kishi, Masayuki Nakano, Akira Takahashi, Yutaka Nakaya, Yousuke Ebina
Publikováno v:
The Journal of Medical Investigation. 54:19-27
There is crosstalk in intracellular signaling between Angiotensin II (Ang II) and insulin. We hypothesized that the underlying mechanism might be related to changes in cytoskeleton. In the presence of 100 nM of Ang II, insulin-induced glucose uptake
Autor:
Yousuke Ebina, Shiying Liu, Qinghua Wang, Toshiyuki Obata, Matthias Braun, Shaoping Deng, Anna Wendt, Mohan Kumar, William Ju, Yi Zhang, Michael B. Wheeler, Nina Zhang, Elaine Xu
Publikováno v:
Cell Metabolism. 3(1):47-58
Excessive secretion of glucagon is a major contributor to the development of diabetic hyperglycemia. Secretion of glucagon is regulated by various nutrients, with glucose being a primary determinant of the rate of alpha cell glucagon secretion. The i
Autor:
Yousuke Ebina, Toshiyuki Obata, Jerrold M. Olefsky, Kun Shi, Takeshi Yoshizaki, Takeshi Imamura, Satoshi Ugi, Katsuya Egawa, Atsunori Kashiwagi, Hiroshi Maegawa
Publikováno v:
Molecular and Cellular Biology. 24:8778-8789
Protein phosphatase 2A (PP2A) is a multimeric serine/threonine phosphatase which has multiple functions, including inhibition of the mitogen-activated protein (MAP) kinase pathway. Simian virus 40 small t antigen specifically inhibits PP2A function b
Autor:
Yukiko Gotoh, Kazuhiro Kishi, Lewis C. Cantley, Norihisa Masuyama, Hiroshi Shiota, Yousuke Ebina, Rie Matsushima, Takashi Katome, Toshiyuki Obata
Publikováno v:
Journal of Biological Chemistry. 278:28312-28323
Insulin plays a central role in the regulation of glucose homeostasis in part by stimulating glucose uptake and glycogen synthesis. The serine/threonine protein kinase Akt has been proposed to mediate insulin signaling in several processes. However,
Autor:
Douglas N. Henry, Ying Jin, Takashi Murakami, Charles W. Heilig, Xuan Qu, Jeffrey I. Kreisberg, Yousuke Ebina, Svend O. Freytag, Lirong Guo, Frank C. Brosius, Kathleen Heilig, Robert D. Loberg
Publikováno v:
American Journal of Physiology-Renal Physiology. 280:F657-F666
A stable clone of rat mesangial cells expressing antisense GLUT-1 (i.e., MCGT1AS cells) was developed to protect them from high glucose exposure. GLUT-1 protein was reduced 50%, and the 2-deoxy-[3H]glucose uptake rate was reduced 33% in MCGT1AS. MCLa
Autor:
Tetsushi Toyonaga, Yousuke Ebina, Hiroyuki Motoshima, Tetsuya Taguchi, Noboru Furukawa, Kazuaki Yoshizato, Eiichi Araki, Yoshiaki Hirashima, Motoaki Shichiri, Junji Kawashima, Tetsuya Shirotani
Publikováno v:
Biochemical and Biophysical Research Communications. 280:428-434
The liver is a major target organ of insulin and is important for glucose homeostasis. We analyzed the tissue specific regulation of the insulin receptor gene in the liver by studying the cis-acting element and trans-acting factor of the human insuli
Autor:
Akifumi Hagi, Lihong Wang, Hideki Hayashi, Kazuhiro Kishi, Yousuke Ebina, Phillip T. Hawkins, Luping Huang, Keisuke Tamaoka
Publikováno v:
Biochemical Journal. 345:543-555
Activation of phosphoinositide 3-kinase (PI-3K) is essential for insulin-stimulated translocation of GLUT4 and glucose transport in insulin target tissues. A novel p110gamma PI-3K was reported to be activated by G(i)-coupled receptors via Gbetagamma