Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Yousuf A Khan"'
Activation of the unfolded protein response in sarcoma cells treated with rapamycin or temsirolimus.
Autor:
Joseph W Briggs, Ling Ren, Kristi R Chakrabarti, Yien Che Tsai, Allan M Weissman, Ryan J Hansen, Daniel L Gustafson, Yousuf A Khan, Jonathan D Dinman, Chand Khanna
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0185089 (2017)
Activation of the unfolded protein response (UPR) in eukaryotic cells represents an evolutionarily conserved response to physiological stress. Here, we report that the mTOR inhibitors rapamycin (sirolimus) and structurally related temsirolimus are ca
Externí odkaz:
https://doaj.org/article/21191385288e488bb0ace408ca335cc3
Publikováno v:
Journal of Animal Science and Biotechnology, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Background Biologically annotated neural networks (BANNs) are feedforward Bayesian neural network models that utilize partially connected architectures based on SNP-set annotations. As an interpretable neural network, BANNs model SNP and SNP
Externí odkaz:
https://doaj.org/article/708739a874934d78b0e79ceb655829ac
Autor:
Saina Yan, Fen Pei, Jingfnag Si, Md. Yousuf Ali Khan, Sihai Ou, Yang Yang, Zongsheng Zhao, Alfredo Pauciullo, Yi Zhang
Publikováno v:
Animal Biotechnology, Vol 35, Iss 1 (2024)
Weaning weight is a key indicator of the early growth performance of cattle. An understanding of the genetic mechanisms underlying weaning weight will help increase the accuracy of selection of breeding animals. In order to identify candidate genes a
Externí odkaz:
https://doaj.org/article/22b7887726b24737b6bcac40ac94f5ab
Autor:
Abdullah Ibne Omar, Md. Yousuf Ali Khan, Xin Su, Aashish Dhakal, Shahed Hossain, Mohsin Tarafder Razu, Jingfang Si, Alfredo Pauciullo, Md. Omar Faruque, Yi Zhang
Publikováno v:
Animals, Vol 14, Iss 8, p 1248 (2024)
Household buffalo dairy farming is gaining popularity nowadays in Bangladesh because of the outstanding food value of buffalo milk as well as the lower production cost of buffalo compared to cattle. An initiative has recently been taken for the genet
Externí odkaz:
https://doaj.org/article/716c5a5e2f674264995f09e1b68b0700
Autor:
Yan Gao, Yousuf A. Khan, Weike Mo, K. Ian White, Matthew Perkins, Richard A. Pfuetzner, Josef G. Trapani, Axel T. Brunger, Teresa Nicolson
Publikováno v:
Cell Reports, Vol 42, Iss 4, Pp 112345- (2023)
Summary: The AAA+ NSF complex is responsible for SNARE complex disassembly both before and after membrane fusion. Loss of NSF function results in pronounced developmental and degenerative defects. In a genetic screen for sensory deficits in zebrafish
Externí odkaz:
https://doaj.org/article/fa469058d265459a95ab589acda03f97
Autor:
Yousuf A. Khan, Irwin Jungreis, James C. Wright, Jonathan M. Mudge, Jyoti S. Choudhary, Andrew E. Firth, Manolis Kellis
Publikováno v:
BMC Genetics, Vol 21, Iss 1, Pp 1-16 (2020)
Abstract Background POLG, located on nuclear chromosome 15, encodes the DNA polymerase γ(Pol γ). Pol γ is responsible for the replication and repair of mitochondrial DNA (mtDNA). Pol γ is the only DNA polymerase found in mitochondria for most ani
Externí odkaz:
https://doaj.org/article/538bb7803ef24b5c896e5f91b7bc7e25
Autor:
Yousuf A. Khan, Gary Loughran, Anna-Lena Steckelberg, Katherine Brown, Stephen J. Kiniry, Hazel Stewart, Pavel V. Baranov, Jeffrey S. Kieft, Andrew E. Firth, John F. Atkins
Publikováno v:
Nature
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11200417a01e04a71938b7f37b10a568
https://doi.org/10.1038/s41586-022-04627-y
https://doi.org/10.1038/s41586-022-04627-y
Autor:
Kaiming Zhang, Naoki Horikoshi, Shanshan Li, Alexander S. Powers, Mikhail A. Hameedi, Grigore D. Pintilie, Hee-Don Chae, Yousuf A. Khan, Carl-Mikael Suomivuori, Ron O. Dror, Kathleen M. Sakamoto, Wah Chiu, Soichi Wakatsuki
Publikováno v:
ACS Central Science. 8:214-222
Cryogenic electron microscopy (cryo-EM) has emerged as a viable structural tool for molecular therapeutics development against human diseases. However, it remains a challenge to determine structures of proteins that are flexible and smaller than 30 k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68f4e463150b27a1c86df40f87543184
https://doi.org/10.1021/acscentsci.1c01090
https://doi.org/10.1021/acscentsci.1c01090
Autor:
Yousuf Syed Khan, Charles Majinge
Publikováno v:
Max Planck Yearbook of United Nations Law Online. 24:327-361
Over the past fifteen years, the international community has increasingly relied upon United Nations mandated mechanisms comprising commissions of inquiry, fact- finding missions, and investigations to help address gross violations of human rights an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d5196f8fa7a54ffc8f5b32de3a35c12
https://doi.org/10.1163/18757413_02401011
https://doi.org/10.1163/18757413_02401011
Publikováno v:
Critical Reviews in Biochemistry and Molecular Biology. 57:156-187
ATPases associated with diverse cellular activities (AAA+ proteins) are a superfamily of proteins found throughout all domains of life. The hallmark of this family is a conserved AAA+ domain responsible for a diverse range of cellular activities. Typ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee6525ddca002878fad7e0a3ca73de35
https://doi.org/10.1080/10409238.2021.1979460
https://doi.org/10.1080/10409238.2021.1979460