Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Youssra K. Al-Hilaly"'
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
Oxidative stress is a significant source of damage that accumulates during aging and contributes to Alzheimer’s disease (AD) pathogenesis. Oxidation of proteins can give rise to covalent links between adjacent tyrosines known as dityrosine (DiY) cr
Externí odkaz:
https://doaj.org/article/70a09f36edf04aff9cce76085be19d7f
Autor:
Youssra K. Al-Hilaly, Connor Hurt, Janet E. Rickard, Charles R. Harrington, John M. D. Storey, Claude M. Wischik, Louise C. Serpell, Ansgar B. Siemer
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Aggregation of the tau protein into fibrillar cross-β aggregates is a hallmark of Alzheimer’s diseases (AD) and many other neurodegenerative tauopathies. Recently, several core structures of patient-derived tau paired helical filaments (PHFs) have
Externí odkaz:
https://doaj.org/article/594cc6b618014d32a8d39a0d9b3fe5ca
Autor:
Yann Fichou, Youssra K. Al-Hilaly, François Devred, Caroline Smet-Nocca, Philipp O. Tsvetkov, Joke Verelst, Joris Winderickx, Nick Geukens, Eugeen Vanmechelen, Audrey Perrotin, Louise Serpell, Bernard J Hanseeuw, Miguel Medina, Luc Buée, Isabelle Landrieu
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-17 (2019)
Abstract Insights into tau molecular structures have advanced significantly in recent years. This field has been the subject of recent breakthroughs, including the first cryo-electron microscopy structures of tau filaments from Alzheimer’s and Pick
Externí odkaz:
https://doaj.org/article/bb3797785c9b48ec921123c85a95810a
Autor:
Sebastian S. Oakley, Mahmoud B. Maina, Karen E. Marshall, Youssra K. Al-Hilaly, Charlie R. Harrington, Claude M. Wischik, Louise C. Serpell
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
Tau plays an important pathological role in a group of neurodegenerative diseases called tauopathies, including Alzheimer's disease, Pick's disease, chronic traumatic encephalopathy and corticobasal degeneration. In each disease, tau self-assembles a
Externí odkaz:
https://doaj.org/article/5b7b64b5eba24b5790a5b05d5ddc4ab8
Autor:
Mahmoud B. Maina, Gunasekhar Burra, Youssra K. Al-Hilaly, Kurtis Mengham, Kate Fennell, Louise C. Serpell
Publikováno v:
iScience, Vol 23, Iss 10, Pp 101537- (2020)
Summary: Dityrosine (DiY), via the cross-linking of tyrosine residues, is a marker of protein oxidation, which increases with aging. Amyloid-β (Aβ) forms DiY in vitro and DiY-cross-linked Aβ is found in the brains of patients with Alzheimer diseas
Externí odkaz:
https://doaj.org/article/4f3367717ded4dfe87b1faeb3c86248f
Autor:
Mahmoud B. Maina, Youssra K. Al-Hilaly, Gunasekhar Burra, Janet E. Rickard, Charles R. Harrington, Claude M. Wischik, Louise C. Serpell
Publikováno v:
Cells, Vol 10, Iss 3, p 703 (2021)
The self-assembly of tau into paired helical filaments (PHFs) in neurofibrillary tangles (NFTs) is a significant event in Alzheimer’s disease (AD) pathogenesis. Numerous post-translational modifications enhance or inhibit tau assembly into NFTs. Ox
Externí odkaz:
https://doaj.org/article/8253ab4ebde849ff9bbb23fd6a5f95e4
Publikováno v:
Biomolecules, Vol 6, Iss 1, p 9 (2016)
Tau protein, found in both neuronal and non-neuronal cells, forms aggregates in neurons that constitutes one of the hallmarks of Alzheimer’s disease (AD). For nearly four decades, research efforts have focused more on tau’s role in physiology and
Externí odkaz:
https://doaj.org/article/6bf0aebdad5740df85b67c91c5f150a5
Autor:
Rui Huang, Daniel McDowall, Henry Ng, Lisa Thomson, Youssra K. Al-Hilaly, James Doutch, Sam Burholt, Louise C. Serpell, Robert J. Poole, Dave J. Adams
Publikováno v:
Chemical Communications. 58:10388-10391
A functionalised dipeptide that self-assembles to form wormlike micelles at high pH can be treated as a surfactant. By varying salt concentration, the self-assembled structures and interactions between them change, resulting in solutions with very di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89149a5e9c95ba16cb6c4d2be403b171
https://doi.org/10.1039/d2cc03646k
https://doi.org/10.1039/d2cc03646k
Autor:
Youssra K, Al-Hilaly, Karen E, Marshall, Liisa, Lutter, Luca, Biasetti, Kurtis, Mengham, Charles R, Harrington, Wei-Feng, Xue, Claude M, Wischik, Louise C, Serpell
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2551
Tau is a natively unfolded protein that contributes to the stability of microtubules. Under pathological conditions such as Alzheimer's disease (AD), tau protein misfolds and self-assembles to form paired helical filaments (PHFs) and straight filamen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d5ebe12eb3fbc8d0128307e019baa14d
https://pubmed.ncbi.nlm.nih.gov/36310203
https://pubmed.ncbi.nlm.nih.gov/36310203
Autor:
Youssra K. Al-Hilaly, Karen E. Marshall, Liisa Lutter, Luca Biasetti, Kurtis Mengham, Charles R. Harrington, Wei-Feng Xue, Claude M. Wischik, Louise C. Serpell
Publikováno v:
Methods in Molecular Biology ISBN: 9781071625965
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dfec2dab062f29bdce33aab424c72ec1
https://doi.org/10.1007/978-1-0716-2597-2_12
https://doi.org/10.1007/978-1-0716-2597-2_12
