Výsledky vyhledávání

Akademický článek

Synthesis, Characterization, and In Vitro and In Vivo Evaluations of 4-(N)-Docosahexaenoyl 2′, 2′-Difluorodeoxycytidine with Potent and Broad-Spectrum Antitumor Activity

Autor: Youssef W. Naguib, Dharmika Lansakara-P., Laura M. Lashinger, B. Leticia Rodriguez, Solange Valdes, Mengmeng Niu, Abdulaziz M. Aldayel, Lan Peng, Stephen D. Hursting, Zhengrong Cui

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 18, Iss 1, Pp 33-48 (2016)

In this study, a new compound, 4-(N)-docosahexaenoyl 2′, 2′-difluorodeoxycytidine (DHA-dFdC), was synthesized and characterized. Its antitumor activity was evaluated in cell culture and in mouse models of pancreatic cancer. DHA-dFdC is a poorly s

Externí odkaz: https://doaj.org/article/294c9d15fb374f0a827ef763bc8a6326

Zobrazit plný text záznamu

Akademický článek

The effect of microneedles on the skin permeability and antitumor activity of topical 5-fluorouracil

Autor: Youssef W. Naguib, Amit Kumar, Zhengrong Cui

Publikováno v: Acta Pharmaceutica Sinica B, Vol 4, Iss 1, Pp 94-99 (2014)

Topical 5-fluorouracil (5-FU) is approved for the treatment of superficial basal cell carcinoma and actinic keratosis. However, 5-FU suffers from poor skin permeation. Microneedles have been successfully applied to improve the skin permeability of sm

Externí odkaz: https://doaj.org/article/23f3e51fee014975a78e9d72be06819f

Zobrazit plný text záznamu

Akademický článek

Modified Spraying Technique and Response Surface Methodology for the Preparation and Optimization of Propolis Liposomes of Enhanced Anti-Proliferative Activity against Human Melanoma Cell Line A375

Autor: Hesham Refaat, Youssef W. Naguib, Mahmoud M. A. Elsayed, Hatem A. A. Sarhan, Eman Alaaeldin

Publikováno v: Pharmaceutics, Vol 11, Iss 11, p 558 (2019)

Propolis is a honeybee product that contains a mixture of natural substances with a broad spectrum of biological activities. However, the clinical application of propolis is limited due to the presence of a myriad of constituents with different physi

Externí odkaz: https://doaj.org/article/564aab182a9e4bd1bf65d020bddf397f

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

Acid-Sensitive Sheddable PEGylated PLGA Nanoparticles Increase the Delivery of TNF-α siRNA in Chronic Inflammation Sites

Autor: Abdulaziz M Aldayel, Youssef W Naguib, Hannah L O'Mary, Xu Li, Mengmeng Niu, Tinashe B Ruwona, Zhengrong Cui

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 5, Iss C (2016)

There has been growing interest in utilizing small interfering RNA (siRNA) specific to pro-inflammatory cytokines, such as tumor necrosis factor-α (TNF-α), in chronic inflammation therapy. However, delivery systems that can increase the distributio

Externí odkaz: https://doaj.org/article/d9aed8cb83f54425a632423edc812910

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání