Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Youssef L. Bennani"'
Autor:
Charlotte Avet, Louis Gendron, Camil Elie Sayegh, Joseph A. Mancini, Florence Gross, Christian Le Gouill, Meriem Semache, Youssef L. Bennani, Claudio Sturino, Michel Bouvier, Sébastien Grastilleur
Publikováno v:
Communications Biology
Protease-activated receptor-2 (PAR2) is involved in inflammatory responses and pain, therefore representing a promising therapeutic target for the treatment of immune-mediated inflammatory diseases. However, as for other GPCRs, PAR2 can activate mult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe33a82e299b5c3d3b01de44cc4447ab
https://doi.org/10.1038/s42003-020-01453-8
https://doi.org/10.1038/s42003-020-01453-8
Autor:
Jesús Jiménez-Barbero, Ángeles Canales, Katja Bargsten, María A. Oliva, Michel O. Steinmetz, Andrea E. Prota, Javier Rodríguez-Salarichs, J. Fernando Díaz, Youssef L. Bennani
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Noscapine is a natural alkaloid that is used as an antitussive medicine. However, it also acts as a weak anticancer agent in certain in vivo models through a mechanism that is largely unknown. Here, we performed structural studies and show that the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8375912e026ffea237e1cb8998d7254f
http://hdl.handle.net/10261/216841
http://hdl.handle.net/10261/216841
Autor:
Wenxin Gu, Joshua R. Leeman, Michael P. Clark, Upul K. Bandarage, Paul S. Charifson, Jones Steven, Randal Byrn, Christine Memmott, Jeffery Gillespie, Kwame Nti Addae, Huai Gao, Ioana Davies, Alice Tsai, Hamilton B. Bennett, Mark W. Ledeboer, Kennedy Joseph M, Emanuele Perola, Francois Maltais, Marc Jacobs, Youssef L. Bennani, Colleen O’Brien
Publikováno v:
ACS Medicinal Chemistry Letters. 8:261-265
JNJ-63623872 (2) is a first-in-class, orally bioavailable compound that offers significant potential for the treatment of pandemic and seasonal influenza. Early lead optimization efforts in our 7-azaindole series focused on 1,3-diaminocyclohexyl amid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab26b6feafc6a9c720fbfdc5f3b89551
https://doi.org/10.1021/acsmedchemlett.6b00487
https://doi.org/10.1021/acsmedchemlett.6b00487
Autor:
Youssef L. Bennani, Joseph A. Mancini, Christian Le Gouill, Meriem Semache, Florence Gross, Camil Elie Sayegh, Charlotte Avet, Michel Bouvier
Publikováno v:
The FASEB Journal. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bdc2850dae98f4abaa6244caa5404848
https://doi.org/10.1096/fasebj.2018.32.1_supplement.555.13
https://doi.org/10.1096/fasebj.2018.32.1_supplement.555.13
Autor:
Wenxin Gu, Tiansheng Wang, Joshua R. Leeman, Emanuele Perola, Marc Jacobs, Brian Ledford, Youssef L. Bennani, Paul S. Charifson, Mark W. Ledeboer, Randal R. Byrn, Michael J. Boyd, Hamilton B. Bennett, Ioana Davies, Upul K. Bandarage, Michael P. Clark
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:1990-1994
VX-787 is a first in class, orally bioavailable compound that offers unparalleled potential for the treatment of pandemic and seasonal influenza. As a part of our routine SAR exploration, carboxylic acid isosteres of VX-787 were prepared and tested a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5570edbbfde170dfeff5195c9b78ae0
https://doi.org/10.1016/j.bmcl.2015.03.013
https://doi.org/10.1016/j.bmcl.2015.03.013
Autor:
Simon Giroux, Nigel Ewing, Youssef L. Bennani, Francoise Berlioz-Seux, Rebecca S. Shawgo, Anne-Laure Grillot, Nathalie Chauret, Kevin M. Cottrell, Laval C. Chan, Evelyne Dietrich, Francois Denis, Morris Mark A, John Maxwell, Sanjoy Kumar Das, Lucille L’Heureux, Darius Bilimoria, T. Jagadeeswar Reddy, Subajini Selliah, Caroline Cadilhac, Olivier Nicolas, Jinwang Xu, James A. Henderson, Nagraj Mani
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:936-939
The discovery of C2-symmetric bis-thienoimidazoles HCV NS5A inhibitors is herein reported. Two straightforward approaches to access the requisite diyne and biphenyl linker moieties are described. This study revealed the paramount importance of the ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::597bec3afadcf6a330d92543b0a8f6ee
https://doi.org/10.1016/j.bmcl.2014.12.046
https://doi.org/10.1016/j.bmcl.2014.12.046
Autor:
Youssef L. Bennani, Brian L. Hanzelka, Tiansheng Wang, Guy W. Bemis, Yuzhou Xu, Hongwu Gao, Harmon J. Zuccola, Christopher Locher, Ute Müh, Aixiang Liu, Jeremy Green, John A. Thomson, Michael Wynn, Cameron Stuver Moody, Shaohui Wang, Jie Wang
Drug resistant tuberculosis (TB) infections are on the rise and antibiotics that inhibit Mycobacterium tuberculosis through a novel mechanism could be an important component of evolving TB therapy. Protein kinase A (PknA) and protein kinase B (PknB)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dbd8feef2c91be44426fa4553879953
https://europepmc.org/articles/PMC5733270/
https://europepmc.org/articles/PMC5733270/
Autor:
Michael J. Boyd, Nti-Addae Kwame Wiredu, Randy S. Bethiel, John P. Duffy, Joshua R. Leeman, Rene Rijnbrand, Brian Ledford, Deng Hongbo, Christine Memmott, Tiansheng Wang, Randal Byrn, Hamilton B. Bennett, Luc J. Farmer, Jones Steven, Wenxin Gu, Paul S. Charifson, Youssef L. Bennani, Mark W. Ledeboer, Upul K. Bandarage, Marc Jacobs, Michael P. Clark, Emanuele Perola, Colleen O’Brien, Alice Tsai, Shannon Dean
In our efforts to develop novel small-molecule inhibitors for the treatment of influenza, we utilized molecular modeling and the X-ray crystal structure of the PB2 subunit of the influenza polymerase to optimize a series of acyclic β-amino acid inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::571e3924c774ac8afe409ad89fb6f678
https://europepmc.org/articles/PMC5304291/
https://europepmc.org/articles/PMC5304291/
Autor:
Youssef L. Bennani
Publikováno v:
Drug Discovery Today. 16:779-792
Pharmaceutical companies must find a better way to increase their output of truly new drugs for the benefit of patients and for their business survival. Here, I highlight a general perspective from within pharmaceutical research as it pertains to res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34cb5c5a3dcae2c1bcf7238f95757388
https://doi.org/10.1016/j.drudis.2011.06.004
https://doi.org/10.1016/j.drudis.2011.06.004
Autor:
Elizabeth Ann Gleason, L. Nathan Tumey, Steven M. Murphy, George Mbella Ekema, Bruce Sherf, Robert W. Mays, Joel Danzig, Jianping Song, John J. Harrington, Marc Palmer, Doug Hanniford, Gary Pawlowski, Michael J. Robarge, Chris Doucette, Margaret Loftus, Karen Hunady, Youssef L. Bennani, Alain Stricker-Krongrad, Kurt R. Brunden
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:3287-3290
CRTh2 (DP2) is a prostaglandin D2 receptor implicated in the recruitment of eosinophils and basophils within the asthmatic lung. Here we report the discovery of a novel series of 3-indolyl sultam antagonists with low nM affinity for CRTh2. These comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffa18293dda777349d2cec3a2963cb9c
https://doi.org/10.1016/j.bmcl.2010.04.046
https://doi.org/10.1016/j.bmcl.2010.04.046