A dual-chamber model of the female genital tract to evaluate epithelial toxicity of candidate anti-HIV microbicides

Autor: Kevin K, Ariën, Guido, Vanham, Youssef, Gali

Publikováno v: Current protocols in cell biology.

Heterosexual transmission of human immunodeficiency virus (HIV) is the predominant mode of infection worldwide. The early steps of transepithelial infection are crucial, but how exactly infection is established in the female genital tract (FGT) is st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4a496b99ee2536379b24a3713e0ce9bb
https://pubmed.ncbi.nlm.nih.gov/21898337

Analysis of infectious virus clones from two HIV-1 superinfection cases suggests that the primary strains have lower fitness

Autor: Stefan J. Dekker, Fokla Zorgdrager, Youssef Gali, Guido Vanham, Marion Cornelissen, Karolina Kozaczynska, Ben Berkhout, Kevin K. Ariën, Victoria R Balázs, Antoinette C. van der Kuyl

Publikováno v: Retrovirology, 7(60). BioMed Central
Retrovirology, 7(1). BioMed Central
van der Kuyl, AC, Kozaczynska, K, Ariën, K K, Gali, Y, Balázs, V R, Dekker, S J, Zorgdrager, F, Vanham, G, Berkhout, B & Cornelissen, M 2010, ' Analysis of infectious virus clones from two HIV-1 superinfection cases suggests that the primary strains have lower fitness. ', Retrovirology, vol. 7, no. 60 . https://doi.org/10.1186/1742-4690-7-60
Retrovirology, Vol 7, Iss 1, p 60 (2010)
Retrovirology

Background Two HIV-1 positive patients, L and P, participating in the Amsterdam Cohort studies acquired an HIV-1 superinfection within half a year from their primary HIV-1 infection (Jurriaans et al., JAIDS 2008, 47:69-73). The aim of this study was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16906171342c959795cf254c2f99cddf
https://doi.org/10.1186/1742-4690-7-60

In Vitro evaluation of viability, integrity and inflammation in genital epithelia upon exposure to pharmaceutical excipients and candidate microbicides

Autor: Joachim Brouwers, Guido Vanham, Olivier Delézay, Kevin K. Ariën, Bruno Pozzetto, Noura Addad, Hind Hamzeh-Cognasse, Thomas Bourlet, Patrick Augustijns, Youssef Gali

Publikováno v: Antimicrobial agents and chemotherapy

The use of microbicides is a promising approach for the prevention of HIV-1 transmission. Unfortunately, various candidates failed in clinical trials. In some cases, the candidate microbicide even resulted in enhanced virus transmission. Therefore, t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b48fb500a7eefbcf5a7365b583be5754
http://hdl.handle.net/10390/6378

Development of an in vitro dual-chamber model of the female genital tract as a screening tool for epithelial toxicity

Autor: Olivier Delézay, Youssef Gali, Guido Vanham, Kevin K. Ariën, Marleen Temmerman, Rafael Van den Bergh, Marleen Praet

Publikováno v: Journal of virological methods

Heterosexual transmission of human immunodeficiency virus (HIV-1) is the predominant mode of infection worldwide. However, the early steps of transepithelial infection still need to be clarified. Using epithelial cells, originating from the female ge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09312ecaa34308fd02fbdff4c265f678
https://pubmed.ncbi.nlm.nih.gov/20138087

Replicative fitness of CCR5-using and CXCR4-using human immunodeficiency virus type 1 biological clones

Autor: Youssef Gali, Guido Vanham, Leo Heyndrickx, Kevin K. Ariën, Wouter Janssens, Abdelkarim El-Abdellati

Publikováno v: VIROLOGY
Virology

CCR5-tropic viruses cause the vast majority of new HIV-1 infections while about half of the individuals infected with HIV-1 manifest a co-receptor switch (CCR5 (R5) to CXCR4 (X4)) prior to accelerated disease progression. The underlying biological me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e227d7a4f25f8481fe357b8a770dce3
https://hdl.handle.net/1854/LU-364209