Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Youssef El Fakhry"'
Autor:
Ghada S. Hassan, Hogmin Li, Marina Tiemi Shio, Youssef El Fakhry, Waris A. Shah, Walid Mourad, Amal Nadiri
Publikováno v:
The Journal of Immunology. 192:2543-2550
Mycoplasma arthritidis–derived mitogen (MAM) is a member of the superantigen family that structurally differs from other members while still capable of initiating cognate APC/T cell interaction. In addition to the critical role of MHC class II mole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a95ff0f87f91c6d22528b26ca6c6e1ae
https://doi.org/10.4049/jimmunol.1300591
https://doi.org/10.4049/jimmunol.1300591
Autor:
Youssef El Fakhry, Daniel Jung, Hongmin Li, Walid Mourad, Claire Leveillé, Lara Bou Khzam, Yahye Merhi, Lihui Liu, Haydar Alturaihi, Wenyan Guo, Daniel Yacoub, John A. Wilkins
Publikováno v:
Journal of Biological Chemistry. 287:18055-18066
In addition to its classical CD40 receptor, CD154 also binds to αIIbβ3, α5β1, and αMβ2 integrins. Binding of CD154 to these receptors seems to play a key role in the pathogenic processes of chronic inflammation. This investigation was aimed at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9bb4164a0ebd0f63c3bb5d007b4c110
https://doi.org/10.1074/jbc.m111.333989
https://doi.org/10.1074/jbc.m111.333989
Autor:
Ghada S. Hassan, Claire Léveillé, Walid Mourad, Maria J. Polyak, Amal Nadiri, Manjit Rana, Malek Jundi, Youssef El-Fakhry
Publikováno v:
Current Immunology Reviews. 5:285-299
The discovery of new functions for CD154 and CD40 molecules has expanded our knowledge to claim that CD154 plays well beyond its postulated role in adaptive immunity. Active research in this area has outlined an important role of CD154 and its recept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f1f307e6bfc4ddf8bd33b8119befff8
https://doi.org/10.2174/157339509789503989
https://doi.org/10.2174/157339509789503989
Publikováno v:
Parasite Immunology. 23:297-303
The understanding of the immunopathology of infections caused by microsporidia has pinpointed the importance of T cell-mediated immunity. The immunopathology caused by the interesting protozoan parasite Encephalitozoon intestinalis, a microsporidium
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36f98c0d8122d8a1196bcf9b0939cbd9
https://doi.org/10.1046/j.1365-3024.2001.00386.x
https://doi.org/10.1046/j.1365-3024.2001.00386.x
Publikováno v:
Molecular and Biochemical Parasitology. 110:345-357
The ability of Leishmania to survive within the phagolysosomes of mammalian macrophages is heavily dependent on the developmental regulation of a number of genes. Characterization of genes preferentially expressed during the parasite's intracellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4be573ac6ee104d58e57c774fa2efab4
https://doi.org/10.1016/s0166-6851(00)00290-5
https://doi.org/10.1016/s0166-6851(00)00290-5
Publikováno v:
European journal of immunology. 40(3)
Although signal pathways triggered via the CD40 molecule are well characterized, those induced via CD154 are less known. This study demonstrates that engagement of CD154 in Jurkat D1.1 cells with soluble CD40 leads to PKC alpha and delta activation,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85db9e8829a7bcd0cec7ccd72fe83129
https://pubmed.ncbi.nlm.nih.gov/20039299
https://pubmed.ncbi.nlm.nih.gov/20039299
Autor:
John A Wilkins, Youssef El-Fakhry, Réjean Lapointe, Marlène Bouillon, Claire Léveillé, Walid Mourad, Carlos Reyes-Moreno, Ehssan Sharif-Askari, Wen Guo, Yahye Merhi, Julie Bolduc
Publikováno v:
The Journal of biological chemistry. 282(8)
It was originally thought that the critical role of the CD40 ligand (CD40L) in normal and inflammatory immune responses was mainly mediated through its interaction with the classic receptor, CD40. However, data from CD40L(-/-) and CD40(-/-) mice sugg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01709d47a6d126410796eaee265d2b05
https://pubmed.ncbi.nlm.nih.gov/17182621
https://pubmed.ncbi.nlm.nih.gov/17182621
Autor:
Claire Léveillé, Hayssam Khalil, Marlène Bouillon, Alexandre Brunet, Youssef El Fakhry, Walid Mourad, Jacques Thibodeau
Publikováno v:
The Journal of biological chemistry. 279(18)
Whereas the association of major histocompatibility complex (MHC) class II molecules with the cytoskeleton and their recruitment into lipid rafts play a critical role during cognate T/antigen-presenting cell interactions, MHC class II-induced signals
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b6224a12a6e0a3f0fc02b99eca77186
https://pubmed.ncbi.nlm.nih.gov/14976194
https://pubmed.ncbi.nlm.nih.gov/14976194
Publikováno v:
The Journal of biological chemistry. 278(25)
Zinc-dependent superantigens can be divided into two subfamilies based on how they use zinc ions for interactions with major histocompatibility complex (MHC) class II molecules. Members of the first subfamily use zinc ions for interactions with histi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f67ce5bdc733bb2198563554821baf4
https://pubmed.ncbi.nlm.nih.gov/12676930
https://pubmed.ncbi.nlm.nih.gov/12676930
Autor:
Julie Girouard, Walid Mourad, Jacques Thibodeau, Youssef El Fakhry, Hayssam Khalil, Marlène Bouillon
Publikováno v:
The Journal of biological chemistry. 278(9)
Lipid rafts are plasma membrane microdomains that are highly enriched in signaling molecules and that act as signal transduction platforms for many immune receptors. The involvement of these microdomains in HLA-DR-induced signaling is less well defin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e50db13496f5c09dfce78702bdd0a7b
https://pubmed.ncbi.nlm.nih.gov/12499388
https://pubmed.ncbi.nlm.nih.gov/12499388